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Medical ultrasonic coupling agent with disinfection function and preparation method

An ultrasonic coupling agent and functional technology, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, echo/ultrasonic imaging agents, etc., can solve the problems affecting product safety and stability, toxicity, and poor water solubility And other issues

Inactive Publication Date: 2021-07-06
广州市一杰医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN101219223A discloses a medical ultrasonic coupling agent with sterilization and disinfection functions, in which triclosan fungicides are added, but the concentration of triclosan is relatively high and has certain toxicity
These disinfectants are either poorly soluble in water, or have incompatibility with the gel matrix, and the use of higher doses will affect the safety and stability of the product

Method used

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  • Medical ultrasonic coupling agent with disinfection function and preparation method
  • Medical ultrasonic coupling agent with disinfection function and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0027] A medical ultrasonic coupling agent with a bactericidal function, characterized in that it consists of the following components by weight: 89 parts of carbomer, 0.08 part of o-phthalaldehyde, 0.1 part of chlorhexidine gluconate, 0.10 part of polyethylene glycol 0.04 parts of propylene glycol, 50 parts of glycerol, 1 part of sodium hydroxide, 1 part of menthol, 0.1 part of hydroxypropyl methylcellulose, and 900 parts of purified water.

[0028] A preparation method of a medical ultrasonic coupling agent with bactericidal function, comprising the steps of:

[0029] (1) Pour half of the total amount of purified water into the preparation tank, start the homogeneous mixer, put the weighed carbomer and hydroxypropyl methylcellulose into the preparation tank, stir for 1 hour, and disperse evenly. Then inject half of the total preparation amount of purified water and stir for 30 minutes;

[0030] (2) Dilute propylene glycol and glycerol with the same weight of purified water,...

Embodiment 2

[0035] A medical ultrasonic coupling agent with a bactericidal function, consisting of the following components by weight: 10 parts of carbomer, 0.09 part of phthalaldehyde, 0.5 part of chlorhexidine gluconate, 0.3 part of polyethylene glycol, 0.07 part of propylene glycol parts, 70 parts of glycerin, 5 parts of sodium hydroxide, 4 parts of menthol, 0.5 parts of hydroxypropyl methylcellulose, and 1000 parts of purified water.

[0036] Its preparation method is with embodiment 1.

Embodiment 3

[0038]A medical ultrasonic coupling agent with a bactericidal function, characterized in that: it consists of the following components by weight: 9 parts of carbomer, 0.11 parts of o-phthalaldehyde, 0.3 parts of chlorhexidine gluconate, 0.11 parts of polyethylene glycol 0.05 parts of propylene glycol, 60 parts of glycerin, 3 parts of sodium hydroxide, 3 parts of menthol, 0.3 parts of hydroxypropyl methylcellulose, and 1000 parts of purified water.

[0039] Its preparation method is with embodiment 1.

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Abstract

The invention relates to a medical ultrasonic coupling agent with a sterilization function and a preparation method, and belongs to the technical field of coupling agent processing. The medical ultrasonic coupling agent is prepared from the following components in parts by weight: 8-10 parts of carbomer, 0.08-0.11 part of o-phthalaldehyde, 0.1-0.5 part of chlorhexidine gluconate, 0.1-0.3 part of polyethylene glycol, 0.04-0.07 part of propylene glycol, 50-70 parts of glycerol, 1-5 parts of sodium hydroxide, 1-4 parts of menthol, 0.1-0.5 part of hydroxypropyl methyl cellulose and 900-1000 parts of purified water. The medical ultrasonic coupling agent has good biocompatibility, coupling property and stability, and can effectively ensure the definition and accuracy of ultrasonic instrument inspection and use; and the medical ultrasonic coupling agent is mild in performance, does not irritate the skin, can kill the growth of bacteria, avoids cross infection, and is easy to clean. According to the medical ultrasonic coupling agent with the sterilization function, o-phthalaldehyde and chlorhexidine gluconate are compounded for use, so that a synergistic interaction effect is achieved. The menthol can promote the contact between the o-phthalaldehyde and the chlorhexidine gluconate and disinfection substances, so that the disinfection and sterilization effects are improved.

Description

technical field [0001] The invention relates to a medical ultrasonic coupling agent with bactericidal function and a preparation method thereof, belonging to the technical field of coupling agent processing. Background technique [0002] With the development of society, ultrasound technology is used more and more in medical equipment, and it is widely accepted because of its high diagnostic accuracy and good therapeutic effect. Ultrasound equipment needs to use couplant during inspection. Its purpose is to strengthen the coupling between the ultrasonic probe and human skin, to isolate the air between the ultrasonic probe and the skin of the inspected part, so that the sound wave conduction is not affected by the air and attenuated, so as to Achieve clear imaging effect and accurate diagnosis results. With the increasing demand of national health administrative departments to control cross-contamination in hospitals, the production and marketing of medical ultrasonic couplin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K31/11A61K31/15A61K31/045A61K9/06A61K47/38A61K47/32A61K47/10A61P17/00A61P31/02
CPCA61K9/06A61K31/045A61K31/11A61K31/15A61K47/10A61K47/32A61K47/38A61K49/226A61P17/00A61P31/02A61K2300/00
Inventor 周洪文周若斯
Owner 广州市一杰医药科技有限公司
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