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Method for extracting cistanche tubulosa functional components by adopting eutectic agent

A technology of Cistanche Cistanche and extraction tube, which is applied in the directions of medical preparations with non-active ingredients, medical preparations containing active ingredients, organic non-active ingredients, etc. It can improve the extraction rate, reduce the loss, and achieve the effect of good solubility, etc.

Inactive Publication Date: 2021-06-25
HETIAN DCM MEDICINE BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, poor processing technology and drying treatment method will cause enzyme-catalyzed reaction and cause degradation loss of phenylethanol glycosides, which are rich in active ingredients of Cistanche deserticola, especially two representative active ingredients echinacoside and verbascoside monomer compounds. important factor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A method for extracting functional components of Cistanche tuberosa using a low eutectic solvent, comprising the following steps:

[0028] (1) Take fresh Cistanche tubulosa, wash it, grind it at room temperature and pulverize it into a 200-mesh powder, add water 1.5 times the weight of Cistanche tubulosa, then add an appropriate amount of ascorbic acid, stir and mix evenly;

[0029] (2) Mix choline chloride, proline and water to form a mixed solution, stir at 60°C for 30min, then add it to the product obtained in step (1), extract at 60°C, 420W, ultrasonic circulation for 30min, and filter , collecting the extract; wherein, the mol ratio of choline chloride, proline and water is 1:1:3; the volume ratio of the mixed solution to the product obtained in step (1) is 0.22:1;

[0030] (3) Add sodium lauryl sulfate to the extract, stir for 20 minutes, then add diallyl ether and copper chloride, and react for 20 minutes; wherein, the amount of sodium lauryl sulfate added is Cis...

Embodiment 2

[0034] A method for extracting functional components of Cistanche tuberosa using a low eutectic solvent, comprising the following steps:

[0035] (1) Take fresh Cistanche tubulosa, wash it, grind it at room temperature and pulverize it into a 200-mesh powder, add water 1 times the weight of Cistanche tubulosa, then add ascorbic acid, stir and mix evenly;

[0036] (2) Mix choline chloride, proline and water to form a mixed solution, stir at 80°C for 30min, then add it to the product obtained in step (1), extract at 60°C, 500W, ultrasonic circulation for 30min, and filter , collecting the extract; the mol ratio of the choline chloride, proline and water is 1:0.5:2; the volume ratio of the mixed solution to the product obtained in step (1) is 0.3:1;

[0037] (3) Add sodium lauryl sulfate to the extract, stir for 30 minutes, then add diallyl ether and copper chloride, and react for 15 minutes; wherein, the amount of sodium lauryl sulfate is the weight of Cistanche tubulosa 2%; th...

Embodiment 3

[0041] A method for extracting functional components of Cistanche tuberosa using a low eutectic solvent, comprising the following steps:

[0042] (1) Take fresh Cistanche tuberosa, wash it, grind it at room temperature and pulverize it into a 200-mesh powder, add water 1.5 times the weight of Cistanche tuberose, then add ascorbic acid, stir and mix evenly;

[0043] (2) Mix choline chloride, proline and water to form a mixed solution, stir at 80°C for 50 minutes, then add it to the product obtained in step (1), extract it at 60°C with ultrasonic circulation for 40 minutes, filter, and collect Extract solution; the mol ratio of the choline chloride, proline and water is 0.8:1:2; the volume ratio of the mixed solution to the product obtained in step (1) is 0.6:1;

[0044] (3) Add sodium lauryl sulfate to the extract, stir for 30 min, then add diallyl ether and copper chloride, and react for 30 min; wherein, the amount of sodium lauryl sulfate is the weight of Cistanche tubulosa ...

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Abstract

The invention discloses a method for extracting functional components of cistanche tubulosa. The method comprises the following steps: (1) grinding fresh cistanche tubulosa into powder, adding water, adding ascorbic acid, and performing uniform stirring and mixing; (2) mixing choline chloride, proline and water to form a mixed solution, then adding the mixed solution into a product obtained in the step (1), carrying out ultrasonic circulating extraction for 30-60 minutes, filtering and collecting an extracting solution; (3) adding lauryl sodium sulfate into the extracting solution, performing stirring, then adding diallyl ether and a catalyst, and performing reacting; (4) adjusting the pH value of the product obtained in the step (2) to 1-3, and performing stirring, standing and centrifuging; adjusting the pH value to 7-8, adding ozone to react, and concentrating the extracting solution under reduced pressure; (5) adding the extracting solution into absolute ethyl alcohol, and performing filtering, concentrating and crystallizing. The method can effectively reduce the loss of effective components in the extraction process of cistanche tubulosa.

Description

technical field [0001] The invention belongs to the technical field of compound extraction and preparation, and in particular relates to a method for extracting functional components of Cistanche tubulosa using a low eutectic solvent. Background technique [0002] Herba Cistanches (Herba Cistanches) is a well-known traditional tonic Chinese medicine. The Cistanche deserticola recorded in the 2005 edition of "Chinese Pharmacopoeia" is the dry fleshy stem with scaly leaves of Cistanche deserticola Y.C.Ma and Cistanche deserticola (Schrenk) R.Wight. "Shen Nong's Materia Medica" states: Cistanche "maintains the five labors and seven injuries. It is because the fire is weak and cannot produce soil, and it is not the root of the Qi. In the treatment of women's diseases, salty can soften the hardness and remove the blood. Cistanche stops the discharge of essence Drowning, remove the heat carbuncle in the stem, because it can guide the fire of asthenia, and the elderly are dry and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/64A61K47/18A61K47/20A61K47/08A61K47/04A61K135/00
CPCA61K36/64A61K47/186A61K47/183A61K47/20A61K47/08A61K47/02A61K2236/13A61K2236/15A61K2236/333A61K2236/51
Inventor 游林贺金华毛艳俞新周佳佳
Owner HETIAN DCM MEDICINE BIOLOGICAL TECH
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