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Complex microbial inoculant for relieving insulin resistance caused by long-term low-dose radiation exposure and application thereof

A compound bacterial agent and radiation exposure technology, applied in the field of biomedicine, can solve problems such as insulin resistance and persistent blood sugar increase, and achieve the effect of reducing the expression level, increasing the quantity, and reducing the treatment cost.

Pending Publication Date: 2021-06-25
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, other studies have also shown that radiation energy can cause abnormal proliferation and differentiation of pancreatic β cells by changing cell cycle regulatory factors; it can regulate gluconeogenesis by regulating insulin pathway; it can also affect liver cell endoplasmic reticulum by oxidative damage and other ways Gluconeogenesis, resulting in abnormal glucose metabolism characterized by persistently elevated blood glucose
[0004] At present, there is no effective intervention method for the problem of insulin resistance in the body caused by long-term low-dose irradiation

Method used

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  • Complex microbial inoculant for relieving insulin resistance caused by long-term low-dose radiation exposure and application thereof
  • Complex microbial inoculant for relieving insulin resistance caused by long-term low-dose radiation exposure and application thereof
  • Complex microbial inoculant for relieving insulin resistance caused by long-term low-dose radiation exposure and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 composite bacterial agent

[0031] A complex microbial agent for alleviating insulin resistance caused by long-term low-dose radiation exposure, including a probiotic composition and functional substances. The probiotic composition includes Lactobacillus rhamnosus, Lactobacillus reuteri, Bifidobacterium animalis and Bifidobacterium longum. The functional substances include citrulline, glutathione, coenzyme Q10 and seabuckthorn extract.

[0032] The total number of viable bacteria in the probiotic composition is ≥5.0×10 8 CFU / g, wherein the number of live bacteria of a single probiotic in Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium animalis and Bifidobacterium longum is ≥8.0×10 7 CFU / g, and the number of live bacteria of a single probiotic in Bifidobacterium animalis and Bifidobacterium longum is ≥3.5×10 7 CFU / g.

[0033] The preparation process of the probiotic composition is:

[0034] 1) Making fermentation m...

Embodiment 2

[0044] Embodiment 2 mouse radiation experiment

[0045] The animal experiments in this example were carried out in accordance with the relevant provisions of the National Regulations on the Administration of Experimental Animals, and were approved by the Experimental Animal Management and Animal Welfare Ethics Committee of the Military Medical College.

[0046] The experimental subjects are C57BL / 6J male mice aged 6-8 weeks, each mouse weighs 20-25g, 30 mice in total, 5 mice per cage. The above 30 mice were divided into a control group, a low-dose radiation group and a probiotic intervention group, with 10 mice in each group.

[0047] For the control group, the mice were fed normally, the animal room was alternated day and night for 12h / 12h, room temperature was 20-24° C., and humidity (40%-60%) was in a negative pressure environment, free to eat and drink.

[0048] For the low-dose radiation group, on the basis of normal feeding, a single 0.05Gy cobalt-60 ray was irradiated ...

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Abstract

The invention provides a complex microbial inoculant for relieving insulin resistance caused by long-term low-dose radiation exposure and application thereof, active components of the complex microbial inoculant comprise a probiotic composition and functional substances, the probiotic composition comprises lactobacillus rhamnosus, lactobacillus acidophilus, bifidobacterium animalis and bifidobacterium longum, and the functional substances comprise lactobacillus rhamnosus, lactobacillus acidophilus, bifidobacterium animalis and bifidobacterium longum. The functional substances comprise at least one of citrulline, glutathione, coenzyme Q10 and a sea-buckthorn extract, in the probiotic composition, the total viable count is greater than or equal to 5.0 * 10 < 8 > CFU / g, the viable count of single probiotic in lactobacillus rhamnosus, lactobacillus acidophilus, bifidobacterium animalis and bifidobacterium longum is greater than or equal to 8.0 * 10 < 7 > CFU / g, the viable count of single probiotics in the bifidobacterium animalis and the bifidobacterium longum is greater than or equal to 3.5 * 10 < 7 > CFU / g. The complex microbial inoculant can relieve animal insulin resistance caused by long-term low-dose radiation exposure.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a composite bacterial agent for alleviating insulin resistance caused by long-term low-dose radiation exposure, and specific applications of the composite bacterial agent. Background technique [0002] The International Atomic Energy Organization stipulates that ionizing radiation not exceeding 100mSv is low-dose radiation. According to radiation epidemiology and clinical research, low-dose radiation can induce a variety of diseases, such as cancer, congenital abnormalities, cardiovascular and cerebrovascular diseases, cognitive and other nervous system disorders, cataracts, endocrine disorders, bronchopulmonary damage, digestive system damage and other functional impairments. Compared with high-dose radiation, human beings are more likely to be exposed to low-dose radiation environments, such as nuclear industry workers, radioactive research workers, aviation pilots, etc. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A61K38/06A61K36/185A61P5/50A23L33/135A23L2/39A23C9/123A61K35/745A61K31/198A61K31/122
CPCA61K35/747A61K35/745A61K31/198A61K38/06A61K31/122A61K36/185A61P5/50A23L33/135A23L2/39A23C9/1234A23C9/1238A23V2002/00A23V2400/173A23V2400/175A23V2400/113A23V2400/515A23V2400/533A61K2300/00A23V2200/3204
Inventor 黄瑞雪周平坤刘晓丹鞠昭潘惠及
Owner CENT SOUTH UNIV
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