Co-grinding method for preparing chitosan derivative and PVA blend and application of co-grinding method

Abstract

The invention provides a o-grinding method for preparing a chitosan derivative and PVA blend and application of the method. The co-grinding method is simple in preparation process, mild in reaction condition, low in energy consumption and low in production cost, and can be completed at normal temperature. The preparation process does not need to add a chemical cross-linking agent and has no organic residue. The co-grinding method can also significantly improve the solubility of PVA at normal temperature and shorten the dissolution time, hydrogen bonds can be rapidly formed through the charge-assisted effect after the polyvinyl alcohol and the chitosan derivative are co-ground for 5-30 min, the mechanical performance of the formed film is excellent, and a conventional hot melt blending technology can be effectively replaced. The preparation method is suitable for industrial mass production of daily products such as plastic products and preservative films, and medical consumables such as wound dressings, moisturizing gel, itching-relieving antibacterial consumables and other related products.

Description

technical field [0001] The invention relates to the field of high molecular polymers, in particular to a co-grinding method for preparing chitosan derivatives and PVA blends. Background technique [0002] Chitosan (CS) and its derivatives have good film-forming properties and are widely used in industry as a film-forming material. It has a series of advantages such as good biocompatibility, hemostasis, and antibacterial. However, a single chitosan film has disadvantages such as poor acid and water resistance, brittleness and poor mechanical properties, which largely limit the use of chitosan. Polyvinyl alcohol (polyvinyl alcohol, PVA) is a high molecular polymer with strong film-forming properties, high mechanical strength and toughness, and very good biocompatibility. It is widely used in medicine and artificial material fields. A large number of studies have shown that the blending of polyvinyl alcohol and chitosan derivatives in a certain proportion can effectively impr...

AI Technical Summary

Problems solved by technology

[0003] At present, the mainstream blending technology of polyvinyl alcohol and chitosan derivatives needs to add carcinogenic and highly toxic organic solvents such as propylene oxide as cross-linking agents, which can easily lead to residual organic solvents. The environmental impact assessment requirements for product production Higher, which objectively pushes up the production cost of the product

In addition, due to the long dissolution time of polyvinyl alcohol and chitosan derivatives at room temperature, the cross-linking reaction between the two is slow, and the total reaction time needs to be 4-48h, and the reaction needs to be carried out at 50-95°C [1-5] , thus increasing the cost of industrial production of polyvinyl alcohol and chitosan derivatives

[0004] At present, the disadvantages of the mainstream polyvinyl alcohol and chitosan derivative blending technology are that the preparation time is long, heating is required during the preparation process, labor and energy consumption are large, and cross-linking agents are often added during the preparation process, which can easily lead to Residual organic solvents in the product, especially not suitable for the production of pharmaceutical products

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