Application of columbianadin in preparation of medicines for preventing and/or treating osteoporosis

A technology of dihydrocarcinol and angelic acid ester, applied in the field of medicine, can solve the problems such as no reports and applications of CBN osteoporosis, and achieve the effects of inhibiting osteoclast differentiation, increasing bone density, and improving bone microstructure

Active Publication Date: 2021-06-18
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports and applications of CBN in the prevention and treatment of osteoporosis

Method used

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  • Application of columbianadin in preparation of medicines for preventing and/or treating osteoporosis
  • Application of columbianadin in preparation of medicines for preventing and/or treating osteoporosis
  • Application of columbianadin in preparation of medicines for preventing and/or treating osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 2

[0042] Example 1 The effect of dihydropsaneol-angelate on body weight and food intake of ovariectomized mice

[0043] The above-mentioned experimental animal models and groups were used to monitor the changes in body weight and plasma estradiol of mice in the sham-operated and operated groups at 15 days after surgery. The results are as follows: figure 1 As shown, compared with the sham operation group, the weight of the mice in the operation group was significantly higher (n=12, #P<0.05, compared with the sham operation group), and the level of estradiol in the plasma was significantly lower (n=12, #P<0.05). P<0.05, compared with the sham operation group), indicating that the modeling was successful.

[0044] The body weight and diet (food intake) of the mice in each group were monitored for 10 weeks of continuous administration. The results are as follows figure 2 shown, from figure 2 It can be seen that there is no significant difference in the body weight and diet of t...

Embodiment 2 2

[0045] Example 2 The effect of dihydropsaneol-angelate on bone mineral density in ovariectomized mice

[0046] The above-mentioned experimental animal models and groups were used to detect the effect of dihydrocarcinol angelate on the bone mineral density of ovariectomized mice after continuous administration for 10 weeks. Bone density of the lumbar spine, tibia and femur of the hind leg, results as image 3 As shown in the figure, it can be seen from the figure that compared with the sham operation group, the bone mineral density of the whole body, lumbar spine, hind leg tibia and femur of mice in the model group were significantly decreased (n=12, #P<0.05, compared with the sham operation group). surgery group). Compared with the model group, the bone mineral density of the whole body, the lumbar spine, the tibia and femur of the hind leg of the mice in the combined estrogen group and the high-dose group were significantly increased (n=12, *P<0.05, compared with the model g...

Embodiment 3 2

[0047] Example 3 The effect of dihydropsaneol-angelate on the microstructure of femoral bone in ovariectomized mice

[0048] The above-mentioned experimental animal models and groups were used, and the bone density was detected by dual-energy X-ray absorptiometry. The number of trabecular bone, trabecular bone separation and anisotropy index results such as Figure 4 As shown, compared with the sham-operated group, the trabecular bone connectivity and the number of bone trabeculae in the distal femur of the model group were significantly reduced (n=12, #P<0.05, compared with the sham-operated group), the trabecular bone The degree of separation and anisotropy index were significantly increased (n=12, #P<0.05, compared with the sham operation group), indicating that the mice in the model group had degeneration of the femoral bone microstructure; The trabecular bone connectivity and trabecular number of the distal femur of the mice in the dose group and high-dose group were sig...

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Abstract

The invention provides application of columbianadin in preparation of medicines for preventing and / or treating osteoporosis. The columbianadin can increase bone density, improve the bone microstructure and inhibit osteoclast differentiation, thereby preventing and / or treating osteoporosisand; and thus,the columbianidin can be further used for preparing the medicines for preventing and / or treating the osteoporosis. The invention further provides application of a plant extract and a pharmaceutical composition containing the columbianadin in preparation of medicines for preventing and / or treating osteoporosis. Based on the fact that the columbianidin can inhibit osteoclast differentiation, the invention further provides application of the columbianidin and the pharmaceutical composition containing the columbianidin in preparation of medicines for inhibiting osteoclast differentiation.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to the use of dihydropicolin-angelate in the preparation of a medicament for preventing and / or treating osteoporosis. Background technique [0002] Osteoporosis (OP) is a systemic skeletal disease characterized by decreased bone mass and degeneration of bone microstructure, resulting in increased bone fragility and susceptibility to fractures. At present, traditional Chinese medicine has made remarkable achievements in the treatment of OP. A large number of traditional Chinese medicines and their active ingredients have definite clinical efficacy, and have their unique advantages in the treatment of OP. [0003] Dihydropicolinol angelate (columbianadin, CBN), also known as dihydropicolin, Colombia lactone, is a furanocoumarin compound, which has been proved by pharmacological experiments to have good anti-inflammatory, analgesic, platelet inhibition Aggregation and anti-li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61K36/232A61K36/23A61K36/758A61P19/10
CPCA61K31/37A61K36/232A61K36/23A61K36/758A61P19/10
Inventor 毛浩萍高秀梅常艳旭柴丽娟陈璐韦秋杨云
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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