Simple animal myopia induction device and manufacturing method

Abstract

The invention relates to a simple animal myopia induction device. The simple animal myopia induction device comprises an adaptive sleeve ring, adaptive connecting rods and an adaptive carrier, wherein the adaptive sleeve ring is fixed with an experimental object in an adaptive mode; the adaptive carrier is used for fixing the induction device and can cover a preset induction position of the experimental object, and then the adaptive sleeve ring and the adaptive carrier are connected through the multiple adaptive connecting rods, so that stability and high efficiency are achieved. According to the simple animal myopia induction device, the adaptive sleeve ring, the adaptive connecting rods and the adaptive carrier are all manufactured by 3D printing, the manufacturing of the adaptive sleeve ring, the adaptive connecting rods and the adaptive carrier is matched with the experimental object and an induction carrier, and the experimental object and the induction carrier are directly subjected to matching design through a 3D printing technology, so that the adaptability and stability of the device are effectively ensured, and the rejection feeling of the experiment object can be reduced, so that the experiment progress is smoother; the simple animal myopia induction device has the advantages of being easy to operate, stable in wearing effect, not prone to interference, easy and convenient to manufacture, high in adaptability and capable of not limiting daily activities of the experimental object.

Description

technical field [0001] The invention relates to the field of animal model equipment, in particular to a simple animal myopia induction device. Background technique [0002] Myopia is a hot issue in the world, and it is also a big issue related to the future of our country and nation. According to statistics, in 2012, myopia population in my country was about 450 million, and it will reach 600 million in 2020. The prevalence rate of myopia among young people ranks first in the world. The prevalence rates of myopia among elementary school students, junior high school students and high school students in my country are 34%, 71% and 93% respectively, among which the proportion of high school students with high myopia is 20%, which has increased significantly compared with ten years ago, and the incidence trend Showing younger age accompanied by advanced age. Faced with this grim situation, starting from the mechanism, animal experiments are an important experimental method. Mak...

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Problems solved by technology

[0004] 1. Eyelid suturing; basic operation method: after the mouse is anesthetized, perform eyelid suturing; main advantages: relatively direct and classic method, easy to be accepted by readers, but Disadvantages are: oppressing the eyeball, resulting in increased intraocular pressure, affecting the health of the eyeball; flattening the cornea, changing the real refractive power, so that the results measured in the first few days after the suture removal are often hyperopia, and then slow down. Slowly become myopia; mouse eyelids are small and fragile and easily scratched by mice, which affects the FDM induction effect and is easy to cause infection

[0005] 2. Paste the eye mask; basic operation method: paste the eye mask on the skin around the eyes of the mouse with strong adhesive; main advantages: non-invasive, easy to operate; other The main disadvantage: the pasted eye mask is very easy to be caught by the mouse, and the frequent falling off of the eye mask greatly increases the workload of the researchers and reduces the work efficiency, and the frequent exposure of the FD eye to light will affect the efficiency of FDM induction

Put it on the neck of the mouse to prevent the mouse from tearing off the eye mask. The main advantage: it can prevent the mouse from tearing off the eye mask. The main disadvantage: the collar restricts the activity of the mouse and hinders its water intake and feeding behavior, causing the experimental mouse to move freely The speed and quality of life are significantly reduced. The collar is limited to SUd. The mouse's "face washing action" needs to be manually wiped off the eye dirt every day, which increases the workload of researchers and affects work efficiency. The size of the central hole of the collar is not easy to grasp: If it is too large (loose), the mouse will break free, and if it is too small (tight), it will tighten the neck of the mouse, causing breathing difficulties or even suffocation; moreover, as the mouse grows, the neck will also become thicker, and it must be frequently Adjust the size and tightness of the collar, the daily maintenance is more cumbersome, and the elimination rate is higher

Main disadvantages: Each mouse needs to be operated on in advance, which is cumbersome and requires high technical content; the FD device is complicated and difficult to popularize; the mice suffer a lot of damage and pain

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