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Method for preparing functional coating for promoting bone repair and regeneration on degradable metal surface

A metal surface, metal base technology, applied in the direction of metal material coating process, coating, tissue regeneration, etc., can solve the problem of insufficient ability of the coating to promote bone repair and regeneration, to promote osseointegration and angiogenesis, promote blood vessels The effect of generating, promoting proliferative adhesion and migration

Pending Publication Date: 2021-05-25
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a method for preparing a bone-promoting and regeneration-promoting functional coating on the surface of a degradable metal in view of the above-mentioned deficiencies in the prior art. The hybrid functional coating solves the problem of insufficient ability of the coating in the prior art to promote bone repair and regeneration, and achieves the purpose of simultaneously guiding bone repair and regeneration during the degradation process

Method used

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  • Method for preparing functional coating for promoting bone repair and regeneration on degradable metal surface
  • Method for preparing functional coating for promoting bone repair and regeneration on degradable metal surface
  • Method for preparing functional coating for promoting bone repair and regeneration on degradable metal surface

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Embodiment 1

[0041] A preferred embodiment of the present invention provides a method for preparing a bone-promoting repair and regeneration coating on the surface of degradable zinc metal, the specific steps are as follows:

[0042] a. Grind metal zinc to 2000# with water abrasive paper; use deionized water and absolute ethanol to clean under ultrasonic conditions for 3 times, each time for 3 minutes, and dry it for later use;

[0043] b. Submerging the metal zinc-based layer obtained in step a in a mixed solution of 0.05M zinc nitrate solution and 0.5M sodium hydroxide solution for 2 hours at 70°C to obtain a zinc oxide layer;

[0044] c. Soak the zinc oxide layer obtained in step b in a dopamine solution with a concentration of 2 mg / ml for 6 hours at room temperature and avoid light, then wash and dry, and repeat this step 3 times;

[0045] d. Place the sample obtained in step c at room temperature in a mixture of 5 mM phosphoric acid in PBS buffer, 0.2 mg / mL type I collagen and 200 mM ...

Embodiment 2

[0047] A preferred embodiment of the present invention provides a method for preparing a bone-promoting repair and regeneration coating on the surface of degradable zinc metal, the specific steps are as follows:

[0048] a. Grind metal zinc to 2000# with water abrasive paper; use deionized water and absolute ethanol to clean under ultrasonic conditions for 4 times, each time for 3 minutes and dry for later use;

[0049] b. Submerge the metal zinc-based layer obtained in step a in a mixed solution of 0.04M zinc nitrate solution and 0.6M sodium hydroxide solution for 2 hours at 70°C to obtain a zinc oxide layer;

[0050] c. Soak the zinc oxide layer obtained in step b in a dopamine solution with a concentration of 2.5 mg / ml for 7 hours at room temperature and avoid light, then wash and dry, and repeat this step 3 times;

[0051] d. Place the sample obtained in step c at room temperature in a mixture of 4 mM phosphoric acid in PBS buffer, 0.08 mg / mL type I collagen and 220 mM calci...

Embodiment 3

[0053] A preferred embodiment of the present invention provides a method for preparing a coating for promoting bone repair and regeneration on the surface of degradable magnesium metal. The specific steps are as follows:

[0054] a. Metal magnesium is polished to 2000# with water abrasive paper; use deionized water and absolute ethanol to clean under ultrasonic conditions for 3 times, each time for 3 minutes and dry for later use;

[0055] b. Submerging the metal magnesium-based layer obtained in step a in a mixed solution of 0.06M zinc nitrate solution and 0.5M sodium hydroxide solution for 3 hours at 70°C to obtain a zinc oxide layer;

[0056] c. Soak the zinc oxide layer obtained in step b in a dopamine solution with a concentration of 1.5 mg / ml for 7 hours at room temperature and avoid light, then wash and dry, and repeat this step 3 times;

[0057] d. Place the sample obtained in step c at room temperature in a mixture of 6 mM phosphoric acid in PBS buffer, 0.12 mg / mL typ...

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Abstract

The invention discloses a method for preparing a functional coating for promoting bone repair and regeneration on the surface of degradable metal, which comprises the following steps of: S1, grinding, polishing, cleaning and drying the degradable metal to obtain a metal base layer; s2, soaking the metal base layer obtained in the step S1 in a mixed solution of zinc nitrate and sodium hydroxide for 2-4 h at the temperature of 65-75 DEG C, then treating the metal base layer under ultraviolet light to be irradiated for 6-8 h to form an oxidized metal base layer; s3, soaking the oxidized metal substrate layer obtained in the S2 in a dopamine solution for 6-8 h at the temperature of 20-25 DEG C under the dark condition, and then cleaning and air-drying the oxidized metal substrate layer, and repeating the soaking-cleaning-blow-drying process for 3-5 times; s4, soaking the sample obtained in the step S3 in a mixed solution of a phosphate buffer, I-type collagen and calcium chloride at 20-25 DEG C for 12-24 hours, and cleaning and drying the sample. The problem that in the prior art, a coating is insufficient in bone repair and regeneration promoting capacity is solved, and the purpose of guiding bone repair and regeneration in the degradation process at the same time is achieved.

Description

technical field [0001] The invention belongs to the technical field of biomaterial surface modification, and in particular relates to a method for preparing a bone-promoting and regeneration-promoting functional coating on a degradable metal surface. Background technique [0002] Degradable metals are expected to be used in a new generation of degradable bone implant materials due to their moderate corrosion rate and potential biological functionality of zinc ions. However, the poor osseointegration and insufficient ability to promote bone repair and regeneration of degradable metals are still the key to restricting their clinical application. [0003] At present, research on the surface modification of degradable metals mainly focuses on regulating their corrosion behavior and improving their biocompatibility, and there is insufficient research on promoting bone repair and regeneration. SUMMARY OF THE INVENTION [0004] The purpose of the present invention is to provide ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/32A61L27/34A61L27/50A61L27/54A61L27/58A61L27/04A61L27/28C23C22/60
CPCA61L27/047A61L27/28A61L27/306A61L27/32A61L27/34A61L27/50A61L27/54A61L27/58A61L2300/102A61L2300/112A61L2300/412A61L2400/18A61L2420/02A61L2420/04A61L2420/08A61L2430/02C23C22/60C08L89/00
Inventor 万国江钱军余张文泰曾培杰王佳乐毛金龙黄楠
Owner SOUTHWEST JIAOTONG UNIV
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