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Copper-containing bioactive glass dressing and preparation method thereof

A bioactive glass and sol technology, applied in the field of biomedicine, can solve problems such as cell environment damage, and achieve the effects of simple synthesis steps, mild synthesis steps and easy operation.

Pending Publication Date: 2021-05-14
艾派(广州)医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, copper is a trace element with strong antibacterial activity in the human body. Trace amounts of copper can be beneficial to angiogenesis and antibacterial effects, but excessive copper ion aggregation will catalyze and induce redox reactions and cause damage to the cellular environment

Method used

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  • Copper-containing bioactive glass dressing and preparation method thereof
  • Copper-containing bioactive glass dressing and preparation method thereof
  • Copper-containing bioactive glass dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of 70S bioactive glass dressing: Take a closed container with a cover, add 20ml of ultrapure water, then add 5ml of 2M dilute nitric acid solution, absorb 33.5ml of tetraethyl orthosilicate (TEOS) and add it to the aqueous solution containing nitric acid, and stir the mixture at room temperature Hydrolysis reaction 30min. Then at intervals of 30min, 13.16g of calcium nitrate (Ca(NO 3 ) 2 ·4H 2 (0), 2.9ml triethyl phosphate (TEP), then stirred for 5h until a uniform, transparent sol was formed. The sealed sol was placed at 60°C for 48h, and then dried at 120°C for 24h. The dried gel was ground and then calcined in a muffle furnace at 700°C for 3h. Finally, the calcined sample was ground and passed through a 200-mesh sieve to obtain a powder sample.

Embodiment 2

[0030] Preparation of 0.5% Cu bioactive glass dressing: Take a closed container with a cover, add 20ml of ultrapure water, then add 5ml of 2M dilute nitric acid solution, draw 33.5ml of tetraethyl orthosilicate (TEOS) into the aqueous solution containing nitric acid, mix The hydrolysis reaction was stirred at room temperature for 30 min. Then at intervals of 30min, 12.9g of calcium nitrate (Ca(NO 3 ) 2 ·4H 2 O), 2.9ml triethyl phosphate (TEP) and 0.26g copper nitrate (Cu(NO 3 ) 2 ·3H 2 O), then stirred for 5h until a uniform, transparent sol was formed. The sealed sol was placed at 60°C for 48h, and then dried at 120°C for 24h. The dried gel was ground and then calcined in a muffle furnace at 700°C for 3h. Finally, the calcined sample was ground and passed through a 200-mesh sieve to obtain a powder sample.

Embodiment 3

[0032] Preparation of 1% Cu bioactive glass dressing: Take a closed container with a cover, add 20ml of ultrapure water, then add 5ml of 2M dilute nitric acid solution, draw 33.5ml of tetraethyl orthosilicate (TEOS) into the aqueous solution containing nitric acid, mix The hydrolysis reaction was stirred at room temperature for 30 min. Then at intervals of 30min, 12.65g of calcium nitrate (Ca(NO 3 ) 2 ·4H 2 O), 2.9ml triethyl phosphate (TEP) and 0.52g copper nitrate (Cu(NO 3 ) 2 ·3H 2 O), then stirred for 5h until a uniform, transparent sol was formed. The sealed sol was placed at 60°C for 48h, and then dried at 120°C for 24h. The dried gel was ground and then calcined in a muffle furnace at 700°C for 3h. Finally, the calcined sample was ground and passed through a 200-mesh sieve to obtain a powder sample.

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Abstract

The invention relates to a preparation method of a copper-containing bioactive glass dressing. A sol-gel method is adopted for preparation, ethyl orthosilicate, calcium nitrate, triethyl phosphate and copper nitrate are sequentially added and subjected to a hydrolysis reaction with a dilute nitric acid solution, the molar percentage of SiO2 in the copper-containing bioactive glass dressing is 70%, the molar percentage of copper is 0.5%-1%, and the copper is uniformly distributed in the bioactive glass in the form of Cu<2+>. The copper-containing bioactive dressing prepared by the invention is mild in preparation condition, has very good biocompatibility and a remarkable effect of promoting revascularization, and has a wide application prospect in the treatment aspect of chronic difficult-to-heal wounds, such as diabetic foot ulcer, pressure ulcer, vascular ulcer, burn and scald wounds, postoperative infectious wounds and the like.

Description

technical field [0001] The invention relates to the field of biomedical technology, in particular to a copper-containing bioactive glass dressing and a preparation method thereof. Background technique [0002] The best way to treat wounds clinically is autologous skin transplantation, but for diabetic wounds, autologous skin cannot be used due to pathological problems. However, other treatment methods such as allogeneic skin transplantation and synthetic material repair have certain limitations, such as immune rejection, poor repair effect, and too expensive. Bioactive glass has the effect of promoting angiogenesis in the application research of soft tissue repair or regeneration, and has antibacterial effect, and the price is relatively cheap. [0003] In recent years, the main methods commonly used to prepare bioactive glass are sol-gel method and organic template method, but there is no bioactive glass product with trace elements added based on the above methods, or the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C03C3/097A61L15/18A61L26/00
CPCC03C3/097A61L15/18A61L26/0004
Inventor 何创龙周小军张骞骞牟婵赵剑
Owner 艾派(广州)医疗器械有限公司
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