Organosilicon compound and synthesis method thereof

Abstract

The invention discloses an organosilicon compound and a synthesis method thereof. The comprises the following steps: under the catalytic action of a palladium catalyst, in the presence of an organic solvent and an oxidizing agent, carrying out a C-H activation reaction on an acetophenone derivative provided with a guiding group and hexamethyldisilane to prepare a target product, namely, the organosilicon compound. The method is higher in reaction efficiency and selectivity, an organosilicon compound with a complex structure is obtained in one step, then commercially available acetophenone micromolecules are directly used as a substrate, ortho-position C-H silicification of acetophenone derivatives can be directionally realized under the auxiliary action of a guiding group by installing the guiding group, and the method has higher selectivity. The compound can be further used in the fields of organic synthesis conversion, materials science, medicinal chemistry and the like, and especially has a relatively high potential value and a wide application prospect in the field of medicinal chemistry.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis chemistry, and in particular relates to an organosilicon compound and a synthesis method. Background technique [0002] C-H bonds widely exist in organic compounds, and generally the bond energy is relatively large and relatively stable, so it is not easy to undergo chemical reactions and transform into other functional groups. In the past, the chemical treatment method always gave priority to the use of severe reaction conditions to convert the C-H bond into a C-X (X=Cl, Br, OTs, etc.) And cause waste, efficiency is lower. In recent years, transition metal-catalyzed direct C-H bond activation functionalization reactions have flourished, under the assistance of various guiding groups (monodentate guiding groups, bidentate guiding groups and transient guiding groups, etc.) and catalysts (palladium, etc.) , Chemists have developed various functional grouping methods such as C-H arylation...

AI Technical Summary

Problems solved by technology

[0004] There are many ways to synthesize organosilicon compounds. Traditionally, organosilicon compounds are prepared by the reaction of organometallic intermediates with silicon electrophiles or transition metal-catalyzed coupling reactions of aryl halides with hydrosilanes / disilanes. However, this type of method requires pre-functionalization, which leads to multi-steps to obtain the target product, and there will be halides generated during the reaction, which is not only uneconomical for atoms, but also unfriendly to the environment. The most important thing is that the functionalization of specific sites is difficult. Realization, so it is very important to develop new methods of synthesizing organosilicon compounds

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