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Oroxylin injection and application thereof to preparation of liver cancer drugs

A technology of melaleucain and injection preparations, applied in the field of medicine, can solve the problems of small dosage, high solvent toxicity, poor physical stability, etc., and achieve the effect of stable drug loading

Active Publication Date: 2021-05-07
南京芩领医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most solution preparations have the problems of small dosage and high solvent toxicity, and are only used for cell and animal administration in basic research
Although the dosage of the suspension is large, it has the disadvantages of poor physical stability such as sedimentation and crystal growth, and the dosage is not easy to be accurate.
At present, there is no melaleucain injection preparation with better effect from the perspective of preparation in clinical trials and on the market

Method used

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  • Oroxylin injection and application thereof to preparation of liver cancer drugs
  • Oroxylin injection and application thereof to preparation of liver cancer drugs
  • Oroxylin injection and application thereof to preparation of liver cancer drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Exploring the Prescription of Melaleucain Injection

[0024] According to the results of previous pre-prescription research, a preliminary prescription of melaleucain injection was designed, as shown in Table 1.

[0025] Table 1 Prescription of phyllothin injection

[0026] R1 R2 R3 R4 R5 R6 R7 R8 R9 Melaleuca paper 10g 10g 10g 10g 10g 10g 10g 10g 10g arginine 20g 20g 20g 20g 20g 10g 30g 40g 50g polyethylene glycol 400 0.2L 0.1L 0.0L 0.2L 0.2L 0.2L 0.2L 0.2L 0.2L glucose 50g 50g 50g 25g 0g 50g 50g 50g 50g water for injection to 1L 1L 1L 1L 1L 1L 1L 1L 1L

[0027] The dissolution status, pH, content and impurity investigation of the above-mentioned formulations were further investigated, and the specific results are shown in Table 2-1 and Table 2-2.

[0028] Table 2-1 Prescription (R1-R4) dissolution status, pH, content, impurity inspection results

[0029] prescripti...

Embodiment 2

[0035] Melaleucain Injection (1:2)

[0036] prescription:

[0037] Melaleuca paper 10g

[0038] Arginine 20g

[0039] Macrogol 400 0.2L

[0040] Glucose 50g

[0041] Water for injection to 1.0L.

[0042] Accurately weigh the prescribed amount of phyllophyllin, add the prescribed amount of polyethylene glycol 400, stir to disperse the medicine; take the prescribed amount of L-arginine and put it in another suitable container, add 50-80% of the prescribed amount of boiled Water for injection, stir to dissolve; add it to the kelp, stir to dissolve the kelp; add the prescribed amount of glucose, stir to dissolve; filter through a titanium sand core into a clean container, add Make a sufficient amount of water for injection, stir to make the solution uniform; then filter through a 0.22m microporous membrane, fill in ampoules, and seal. Sterilized by circulating steam at 100°C.

Embodiment 3

[0044] Melaleucain Injection (1:3)

[0045] prescription:

[0046] Melaleuca paper 15g

[0047] Arginine 45g

[0048] Polyethylene glycol 400 0.1L

[0049] Glucose 50g

[0050] Water for injection to 1.0L.

[0051] Accurately weigh the prescribed amount of phyllophyllin, add the prescribed amount of polyethylene glycol 400, stir to disperse the medicine; take the prescribed amount of L-arginine and put it in another suitable container, add 50-80% of the prescribed amount of boiled Water for injection, stir to dissolve; add it to the kelp, stir to dissolve the kelp; add the prescribed amount of glucose, stir to dissolve; filter through a titanium sand core into a clean container, add Make a sufficient amount of water for injection, stir to make the solution uniform; then filter through a 0.22m microporous membrane, fill in ampoules, and seal. Sterilized by circulating steam at 100°C.

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Abstract

The invention discloses an oroxylin injection and an application thereof to preparation of liver cancer drugs, and belongs to the technical field of drugs. The oroxylin injection preparation is prepared from the following components: oroxylin, arginine, polyethylene glycol 400, glucose and water for injection. According to the oroxylin injection disclosed by the invention, a prescription composition and dosage cooperating with the oroxylin injection are designed and optimized from the perspective of pharmaceutics according to the physicochemical properties of the oroxylin, so that the safe and stable oroxylin injection with large drug loading capacity is obtained. The prepared oroxylin injection is used for performing pharmacodynamic investigation on human liver cancer HepG2 nude mouse xenotransplantation tumors, and a foundation is laid for clinical application of the oroxylin to treatment of liver cancer.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a kelp paper injection, a preparation method thereof, and an application in the preparation of liver cancer medicines. Background technique [0002] Oroxylin A is one of the active components of Scutellaria baicalensis. It has obvious antitumor effect and is a natural antitumor drug with broad application prospects. However, the pharmacological effects of kelciene are extensive, and the mechanism of its anti-tumor effect has not yet been fully elucidated. The literature shows that celestein can exert its anti-tumor effect by inducing tumor cell apoptosis, and also has the effect of inhibiting the growth of tumor blood vessels. At the same time, the anti-cancer effect of celesteol is different from that of general chemotherapy and anti-cancer drugs. It can selectively kill tumor cells and has little effect on the normal hematopoietic system, which is not available in ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/10A61K47/18A61K47/26A61K31/352A61P35/00
CPCA61K9/08A61K9/0019A61K47/10A61K47/183A61K47/26A61K31/352A61P35/00
Inventor 柯学步中强郭青龙
Owner 南京芩领医药科技有限公司
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