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Device and method for detecting human immunodeficiency virus based on neural network

A technology of AIDS virus and neural network, applied in the field of devices for detecting AIDS virus, which can solve the problems that the research on devices and methods for detecting AIDS virus has not been reported yet

Active Publication Date: 2021-04-20
武汉乾谷光科生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, research on devices and methods for detecting HIV based on near-infrared absorption spectra has not been reported yet.

Method used

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  • Device and method for detecting human immunodeficiency virus based on neural network
  • Device and method for detecting human immunodeficiency virus based on neural network
  • Device and method for detecting human immunodeficiency virus based on neural network

Examples

Experimental program
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Effect test

Embodiment 1

[0026] 1. Preparation of standard series of HIV-1-NL4-nano, HIV-1-NL4-EGFP virus and MLV virus

[0027] Accurately draw 200ul p24 concentration (34.4×10 6 pg / mL) HIV-1-NL4-nano virus solution, dilute to 6.9ml with serum to obtain 1x10 6 pg / ml HIV-1-NL4-nano virus stock solution, use 1x10 6 The HIV-1-NL4-nano virus stock solution and serum (as diluent) of pg / ml were respectively prepared according to 10-fold dilution, and 100ul virus solution was added to 900ul serum to obtain 1x10 5 , and so on to get 1x10 4 , 1x10 3 , 1x10 2 , 1x10 1 and 1x10 0 HIV-1-NL4-nano virus standard dilution in pg / ml.

[0028] Accurately draw 200ul p24 concentration (40.5×10 6 pg / mL) HIV-1-NL4-EGFP virus solution, dilute to 8.1ml with serum, get 1x10 6 pg / ml HIV-1-NL4-EGFP virus stock solution, use 1x10 6 The HIV-1-NL4-EGFP virus stock solution and serum (as diluent) of pg / ml were respectively prepared according to 10-fold dilution, and 100ul virus solution was added to 900ul serum to obtain...

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Abstract

The invention relates to a device for detecting human immunodeficiency virus based on neural network. The device comprises a near-infrared spectrophotometer and a computer, the computer is used for receiving absorption spectrogram data obtained by the near-infrared spectrophotometer, and the computer comprises a module for removing background absorption based on a blank serum absorption spectrogram, a module for performing first-order differential processing on spectral data after background absorption removal, a module for dividing a first-order differential processing result into a plurality of sections and performing partial least squares algorithm fitting on each section, a module for determining an absorption peak value for all absorption spectrogram data with the AIDS viruses and a module for calculating the toxicity concentration of the absorption spectrogram data of the AIDS virus based on the absorption peak value. The detection device and a detection method provided by the invention can determine the concentration of the AIDS virus in a very simple and easy-to-operate manner, also have very high sensitivity, and provide a new route for realizing AIDS prevention and control.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a neural network-based device and method for detecting HIV. Background technique [0002] AIDS is an infectious disease caused by human immunodeficiency virus (Human Immunodeficiency Virus, HIV) infection that seriously threatens the safety of human life. AIDS has been prevalent in my country for decades. In 2018 alone, the number of new infections in my country was close to 150,000. With the continuous increase of infected persons and clinical patients, and the change of infected population, the workload of AIDS testing has gradually increased. Testing is the first step in the prevention and treatment of AIDS, and expanding testing is also a long-term AIDS prevention and control strategy in my country. Only by timely diagnosis and detection of HIV-infected patients can antiviral treatment be initiated, reduce HIV transmission and improve the prognosis of pati...

Claims

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Application Information

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IPC IPC(8): G01N21/359G01N21/3577G06N3/04G06N3/08
Inventor 顾潮江王全贵罗备
Owner 武汉乾谷光科生物技术有限公司
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