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Long-acting superhydrophobic anticoagulation biovalve and preparation method therefor

A biological valve and super-hydrophobic technology, which is applied in the fields of pharmaceutical formulation, tissue regeneration, drug delivery, etc., can solve the problems of thrombus formation, impact on valve durability, and increased risk of stroke, etc., and achieve resistance to thrombosis and stable super-hydrophobic performance , The effect achieved by adsorption

Active Publication Date: 2021-04-13
JILIN VENUS HAOYUE MEDICAL LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the implantation of biological valves in interventional therapy will lead to thrombosis, and the detachment of thrombus on the surface of the valve will increase the risk of postoperative stroke; and the thrombosis on the surface of the valve will have a serious impact on the durability of the valve.

Method used

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  • Long-acting superhydrophobic anticoagulation biovalve and preparation method therefor
  • Long-acting superhydrophobic anticoagulation biovalve and preparation method therefor
  • Long-acting superhydrophobic anticoagulation biovalve and preparation method therefor

Examples

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Effect test

Embodiment 1

[0032] A method for preparing a long-acting superhydrophobic anticoagulant biological valve, comprising the following steps:

[0033] (1) Pretreatment of the porcine pericardial valve material after glutaraldehyde cross-linking;

[0034] (2) Submerge the porcine pericardial valve material processed in step (1) in tannic acid and Cu with a molar mass ratio of 1:0.1 2+ In the buffer solution of ions, the buffer solution is acetic acid-sodium acetate, its pH is 4, then add sodium periodate oxidant with a concentration of 20 μM in the solution, and react at 25 °C for 40 minutes to make tannic acid undergo oxidative polymerization and simultaneously react with Cu 2+ Ion chelation, generating Cu-containing on the surface of biological valve materials 2+ polyphenol nanoparticles;

[0035] (3) Contain Cu on the surface 2+ The polyphenol nanoparticle porcine pericardial valve material was immersed in 1H,1H,2H,2H-perfluorododecanethiol with a molar concentration of 0.8mM for 20min, ...

Embodiment 2

[0037] A method for preparing a long-acting superhydrophobic anticoagulant biological valve, comprising the following steps:

[0038] (1) Pretreatment of the porcine pericardial valve material after glutaraldehyde cross-linking;

[0039] (2) Submerge the porcine pericardial valve material processed in step (1) in the epigallocatechin gallate and Ag containing molar mass ratio of 1:0.05 + In the buffer solution of ions, the buffer solution is glycine-hydrochloric acid buffer solution, its pH is 4, then add concentrated nitric acid oxidant with a concentration of 80 μM in the solution, and react at 25 °C for 60 minutes to oxidize epigallocatechin gallate Ag + Ion chelation, generating Ag-containing materials on the surface of biological valve materials + polyphenol nanoparticles;

[0040] (3) Contain Ag on the surface + The polyphenol nanoparticle porcine pericardial valve material was soaked in perfluorododecanoic acid with a molar concentration of 0.5mM for 25min, and then...

Embodiment 3

[0042] A method for preparing a long-acting superhydrophobic anticoagulant biological valve, comprising the following steps:

[0043] (1) pretreat the bovine pericardial valve material after glutaraldehyde crosslinking;

[0044] (2) Submerge the porcine pericardial valve material treated in step (1) in epicatechin and Ag containing molar mass ratio of 1:0.2 + In the buffer solution of ions, the buffer solution is disodium hydrogen phosphate-citric acid buffer solution, its pH is 4, and then a potassium permanganate oxidant with a concentration of 0.05mM is added to the solution, and reacted at 20°C for 40min to make epicatechin The oxidative polymerization reaction of the element and the Ag + Ion chelation, generating Ag-containing materials on the surface of biological valve materials + polyphenol nanoparticles;

[0045] (3) Contain Ag on the surface + The polyphenol nanoparticle bovine pericardial valve material was soaked in octadecanoyl chloride with a molar concentrat...

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Abstract

The invention discloses a long-acting superhydrophobic anticoagulation biovalve and a preparation method therefor. The method comprises the following steps: (1) treating a biovalve material with glutaraldehyde for 48 to 96 hours; (2) embedding nanoparticles, which are polymerized from polyphenol compounds and metal ions and contain double-bond groups, in the surface of the biovalve material; and (3) grafting surfaces of the nanoparticles with a hydrophobic substance, so as to form a hydrophobic coating. According to the long-acting superhydrophobic anticoagulation biovalve and the preparation method therefor, the superhydrophobic coating with a long-acting high water contact angle and a low roll angle is prepared on the surface of the biovalve through a simple and stable operating process without affecting properties of a valve body in accordance with moderate self-polymerization reaction conditions of polyphenols and elicitation of a reaction mechanism of the metal ions, double bonds and mercapto groups, and the requirements on long-acting anticoagulation are met through impeding adsorption of plasma proteins.

Description

technical field [0001] The invention belongs to the technical field of valve material preparation, and in particular relates to a long-acting superhydrophobic anticoagulant biological valve and a preparation method thereof. Background technique [0002] As my country's social population structure enters the aging stage, the number of patients with severe valvular stenosis and regurgitation has increased significantly compared with before. The overall incidence rate of people over 75 years old is relatively high. Once patients have symptoms and have not received treatment, they will die within 2 to 3 years. Closer to 50%. Minimally invasive interventional valve surgery is becoming an important treatment measure accepted by more and more patients because of its small surgical trauma, low risk and good effect. Many corresponding questions. Among them, the implantation of biological valves in interventional therapy will lead to thrombosis, and the detachment of thrombus on the ...

Claims

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Application Information

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IPC IPC(8): A61L27/28A61L27/34A61L27/36A61L27/50C08G65/44
CPCA61L27/3625A61L27/3687A61L27/28A61L27/34A61L27/50C08G65/44A61L2400/18A61L2420/04A61L2430/20C08L71/08C08L71/00A61L27/306A61L2300/606A61L2400/12A61L2430/40A61L2300/42A61L2300/216
Inventor 杨立王云兵罗日方
Owner JILIN VENUS HAOYUE MEDICAL LTD
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