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Precursor solution of hydrophilic lubricating coating and application of precursor solution to preparation of surface coating of medical instrument

A technology of lubricating coatings and medical devices, applied in the preparation of surface coatings of medical devices, in the field of precursor liquid of hydrophilic lubricating coatings, can solve problems such as shedding, blood vessel blockage, side effects, etc., and achieve good biocompatibility , Improve rejection, good biocompatibility

Pending Publication Date: 2021-04-09
苏州凝智新材料发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these hydrophilic coatings have improved the lubricity and hydrophilicity on medical devices and consumables, the coating materials themselves cannot form effective chemical bonds with the substrate, so they are not stable during long-term use. Generally, there will be problems such as shedding or failure, and the shedding coating material may cause further blockage of blood vessels, resulting in more serious side effects
CN 104936628 A uses polyvalent cationic substances to make sulfated / sulfonated substances and themselves and negatively charged substances as coating materials, and in-situ polymerizes them on the surface of medical devices after surface activation to form hydrophilic polymer coatings, although The coating can form relatively strong adhesion with the substrate, but its in-situ polymerization method requires ultraviolet light treatment under the condition of isolating oxygen, and the manufacturing process is relatively complicated and the cost is high
CN 110819183 A selects water-soluble monomer as the coating precursor material, uses silane coupling agent as the functional group for bonding, and realizes firm hydrophilic coating on the surface of medical equipment through the method of initiating polymerization-dipping coating-heating and curing layer, but the coating material may contain unreacted monomeric raw materials, affecting the biocompatibility of the overall device, and the entire coating process takes a long time, which is not conducive to mass production
[0004] In general, the existing hydrophilic coating materials and preparation methods cannot guarantee long-term and stable lubricating performance, and there are also certain defects in the manufacturing process, which cannot meet the large-scale and rapid production process. And the required cost is high; in addition, the existing coating method cannot be applied to devices with a variety of different substrates, which further increases the difficulty and cost of medical device coating

Method used

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  • Precursor solution of hydrophilic lubricating coating and application of precursor solution to preparation of surface coating of medical instrument
  • Precursor solution of hydrophilic lubricating coating and application of precursor solution to preparation of surface coating of medical instrument
  • Precursor solution of hydrophilic lubricating coating and application of precursor solution to preparation of surface coating of medical instrument

Examples

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Effect test

Embodiment 1

[0067] A kind of hydrophilic lubricating coating for Pebax (polyether block polyamide) guide wire surface, its preparation method is as follows:

[0068] (1) Polyvinylpyrrolidone (model Sigma-Aldrich#PVP360, molecular weight is about 360000) with a mass fraction of 13% and benzophenone with a mass fraction of 0.5% are uniformly dissolved in water and ethanol (volume ratio is 1:1 ) in the mixed solution to obtain the precursor solution of the hydrophilic lubricating coating;

[0069] (2) Clean the surface of the Pebax guide wire with isopropanol, ethanol and water in sequence, and let it dry for 3 minutes;

[0070] (3) Oxygen plasma treatment was carried out on the guide wire for 1 min, and then further soaked in an aqueous solution of 1% trimethoxy (propyl) silane by mass fraction for 60 min to activate the surface;

[0071] (4) The precursor solution obtained in step (1) is coated on the surface of the Pebax guide wire after step (3) by the dipping method, and the pulling sp...

Embodiment 2

[0074] This embodiment provides a hydrophilic lubricating coating for the surface of a stainless steel guide wire, the preparation method of which is as follows:

[0075] (1) The polyethylene glycol (model is Supelco 81206, molecular weight is about 218000) that the mass fraction is 10% and the benzophenone that the mass fraction is 0.2% are dissolved in water and ethanol (volume ratio is 1.2:1) In the mixed solution, the precursor solution of hydrophilic lubricating coating is obtained;

[0076] (2) Clean the surface of the stainless steel guide wire with isopropanol and water successively, and after drying for 5 minutes, place it in an acid wash containing 20% ​​hydrochloric acid and 5% hydrogen peroxide for 20 minutes, take it out, and dry it for 5 minutes;

[0077] (3) Oxygen plasma treatment was carried out to the guide wire for 20 min, and then further soaked in a mixed solution of 2% 3-(trimethoxysilyl) propyl methacrylate and ethanol for 90 min to make it Surface acti...

Embodiment 3

[0081] This embodiment provides a hydrophilic lubricating coating for the surface of a stainless steel guide wire, the preparation method of which is as follows:

[0082] (1) Agarose (model is Sigma-Aldrich#A1296) with a mass fraction of 5% and coumarone with a mass fraction of 2% are uniformly dissolved in a mixed solution of water and ethanol (volume ratio of 1.2:1), Obtain the precursor solution of hydrophilic lubricating coating;

[0083] (2) Clean the surface of the stainless steel guide wire with isopropanol and water successively, and after drying for 1 min, place it in an acid wash containing 20% ​​hydrochloric acid and 5% hydrogen peroxide for 20 min, take it out, and dry it for 5 min;

[0084] (3) Carry out oxygen plasma treatment 3min to guide wire, further soak 30min in the mixed solution of water and ethanol of 3-(trimethoxysilyl) propyl methacrylate that mass fraction is 4%, make it Surface activation, wherein the volume ratio of water to ethanol is 9:1;

[008...

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Abstract

The invention provides a precursor solution of a hydrophilic lubricating coating and application of the precursor solution to preparation of a surface coating of a medical instrument. The precursor solution is composed of a hydrophilic polymer material, an initiator and a solvent. The hydrophilic lubricating coating provided by the invention has the characteristics of super lubrication and hydrophilicity, can be universally applied to medical equipment comprising various base materials such as macromolecules and metals, and can form firm covalent bonds with the medical equipment, so the hydrophilic lubricating coating on the surface of the medical equipment is stable and long-acting; and meanwhile, the curing process of the hydrophilic lubricating coating provided by the invention does not have a monomer polymerization process, so the hydrophilic lubricating coating can be ensured to have excellent biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and relates to a precursor solution of a hydrophilic lubricating coating and its application in the preparation of surface coatings of medical devices. Background technique [0002] Vascular disease is one of the causes of death and disability in humans today. In order to prevent blood vessel blockage, doctors use implanted and interventional medical devices, such as guide wires, catheters, and stents, to treat blocked blood vessels and blood vessel walls. Unblock and dilate. During the operation, special lubricating coating treatment is applied to the device to reduce the friction between the device and the blood vessel, which can effectively reduce the difficulty of the doctor's operation, improve the success rate of the operation, and reduce the pain of the patient. It can prevent restenosis symptoms after stent implantation, thereby promoting the efficacy of medical devices and prolo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09D139/06C09D171/02C09D105/12C09D189/00
CPCC09D105/12C09D139/06C09D171/02C09D189/00
Inventor 程思博念国栋夏崟
Owner 苏州凝智新材料发展有限公司
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