In-situ rapid prototyping magnetic hydrogel for urinary system repair and preparation method thereof

Abstract

The invention discloses an in-situ rapid prototyping magnetic hydrogel for urinary system repair and a preparation method thereof. The magnetic hydrogel is double-network hydrogel, and comprises monomer acrylamide, a cross-linking agent and a photoinitiator of a first network, and carboxymethyl chitosan and magnetic nanoparticles gamma-Fe2O3 of a second network; the preparation method of the in-situ rapid prototyping magnetic hydrogel comprises the following steps: in-situ injecting a hydrogel precursor solution into a urinary system injury part of a human body, such as bladder and vaginal fistula, and rapidly prototyping the hydrogel precursor solution for 5 seconds under blue light of 405 nanometers to form the hydrogel adapting to the shape of the inner wall of the bladder and vaginal fistula. The magnetic hydrogel has the properties of in-situ rapid prototyping, high swelling rate, traceability and the like, and meanwhile, can promote cell adhesion, so that the repair of the injurypart is accelerated. The preparation process of the in-situ rapid prototyping magnetic hydrogel is simple and convenient, surgical operation is simple and convenient, and large-scale production is facilitated from the perspective of industrialization.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, and in particular relates to an in-situ rapid prototyping magnetic hydrogel for urinary system repair and a preparation method thereof. Background technique [0002] A bladder fistula is the partial or complete excretion of urine through an abnormal channel in the bladder or through another organ in the body. Among them, vesicovaginal fistula is the most common. It is an abnormal fistula between the bladder and the vagina. The clinical manifestation is continuous leakage of urine, which is easy to cause infection and seriously affects the quality of life. The current repair operation often needs to take autologous tissue as filler, such as omentum, muscle flap and so on. There are problems such as complicated operation, large trauma, and potential complications. [0003] As a three-dimensional polymer network with high water content, hydrogel is often used as an implant in the body because i...

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Problems solved by technology

[0005] The main purpose of the present invention is to provide an in-situ rapid prototyping magnetic hydrogel for urinary system repair and its preparation method, so as to overcome the existing defects of difficult operation and poor mechanical properties in the prior art

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