Preparation method of high-viscosity medical composite adhesive

A composite adhesive and a technology of preparation steps, which are applied in the fields of surgical adhesives, applications, medical science, etc., can solve the problems of weak adhesive force and incapable of high-strength bonding, and achieve excellent resilience, excellent antibacterial properties, The effect of good adhesion

Inactive Publication Date: 2021-04-02
成都煌泓亢环保科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention: Aiming at the problem that the current α-cyanoacrylate medical adhesives have weak adhesive force and cannot be used for high-strength bonding, a preparation method of a high-adhesion medical composite adhesive is provided

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]In terms of parts by weight, weigh 10 parts of silkworm cocoons, 5 parts of sodium carbonate, 5 parts of sodium bicarbonate, and 50 parts of deionized water, add sodium carbonate and sodium bicarbonate into the deionized water, and use 160~200r / min at room temperature Stir at a rotating speed for 20 minutes to obtain an alkaline solution. Add silkworm cocoons to the alkaline solution, stir for 2 hours at a rotating speed of 200r / min in a water bath at 80°C, filter, take the filter cake, wash 3 times with deionized water, and place at 40°C Dry in an oven for 2 hours, cool at room temperature, and shear to obtain silk fibroin fibers with an average length of 2mm;

[0033] In parts by weight, weigh 5 parts of chitosan, 5 parts of 3,4-dihydroxyphenylacetic acid, 5 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide salt salt, 5 parts of N-hydroxysuccinimide, 20 parts of hydrochloric acid with a mass fraction of 10%, 50 parts of absolute ethanol, 100 parts of deionized wat...

Embodiment 2

[0036] In terms of parts by weight, weigh 15 parts of silkworm cocoons, 7.5 parts of sodium carbonate, 7.5 parts of sodium bicarbonate, and 75 parts of deionized water, add sodium carbonate and sodium bicarbonate into the deionized water, and stir at a speed of 180 r / min at room temperature After 25 minutes, the alkaline solution was obtained. Add silkworm cocoons into the alkaline solution, stir for 3 hours at a speed of 220r / min in a water bath at 85°C, filter, take the filter cake, wash it with deionized water for 4 times, and place it in an oven at 45°C Dry for 3 hours, cool at room temperature, and shear to obtain silk fibroin fibers with an average length of 3mm;

[0037] In parts by weight, weigh 7.5 parts of chitosan, 7.5 parts of 3,4-dihydroxyphenylacetic acid, and 7.5 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide salt salt, 7.5 parts of N-hydroxysuccinimide, 30 parts of hydrochloric acid with a mass fraction of 10%, 75 parts of absolute ethanol, 150 parts of...

Embodiment 3

[0040] In parts by weight, weigh 20 parts of silkworm cocoons, 10 parts of sodium carbonate, 10 parts of sodium bicarbonate, and 100 parts of deionized water, add sodium carbonate and sodium bicarbonate into the deionized water, and stir at 200 r / min at room temperature After 30 minutes, the alkaline solution was obtained. Add silkworm cocoons into the alkaline solution, stir for 4 hours in a water bath at 90°C at a speed of 240r / min, filter, take the filter cake, wash it with deionized water for 5 times, and place it in an oven at 50°C Dry in medium for 4 hours, cool at room temperature, and shear to obtain silk fibroin fibers with an average length of 4mm;

[0041] In parts by weight, weigh 10 parts of chitosan, 10 parts of 3,4-dihydroxyphenylacetic acid, 10 parts of 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide salt salt, 10 parts of N-hydroxysuccinimide, 40 parts of hydrochloric acid with a mass fraction of 10%, 100 parts of absolute ethanol, 200 parts of deionized water,...

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Abstract

The invention relates to a preparation method of a high-viscosity medical composite adhesive, and belongs to the technical field of medical adhesives. Silk fibroin fibers and catechol modified chitosan are used as raw materials, betaine surfactants are added, the high-viscosity medical composite adhesive is prepared, silk fibroin has a three-dimensional network structure, good biocompatibility anda highly cross-linked space network structure, and the silk fibroin hydrogel has good viscosity and excellent resilience due to addition of the betaine surfactants. Amino exists in chitosan molecules, catechol groups are combined with chitosan backbones by a chemical modification method, and the adhesion capacity and the waterproof adhesion capacity of the medical adhesive can be effectively improved.

Description

technical field [0001] The invention relates to a preparation method of a high-bonding medical composite adhesive, which belongs to the technical field of medical adhesives. Background technique [0002] Medical adhesives are a very important class of new medical materials that have been widely used. The emergence of surgical adhesives provides an extremely convenient method for wound healing, because they exhibit some beneficial functions, such as reducing surgical suturing time, reducing patient blood loss, reducing surgical complications (such as infection, etc.), and convenient application. However, the adhesive strength of biological tissues is a very challenging task, and the adhesive material should exhibit suitable physical properties (elasticity, tensile strength and adhesive strength, etc.) when in contact with physiological fluids, biocompatibility and biodegradability. [0003] In recent years, α-cyanoacrylate medical glue has been developed rapidly. It can be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00A61L24/02A61L24/10C08B37/08D01F4/02
CPCA61L24/08A61L24/108A61L24/02A61L24/0042C08B37/003D01F4/02C08L5/08C08L89/00
Inventor 雷海金
Owner 成都煌泓亢环保科技有限公司
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