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Eutectic of betaine and organic acid as well as preparation method and application of eutectic

An organic acid and betaine technology, applied in the preparation of organic compounds, organic chemistry methods, carboxylate preparation and other directions, can solve the problems of insignificant improvement of the effect, and achieve the effects of reducing the difficulty of preparation, high stability and lowering temperature.

Active Publication Date: 2021-03-19
SHENZHEN SHINESKY BIOLOGICAL TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a co-crystal of betaine and organic acid and its preparation method and application in view of the above-mentioned defects of the prior art, aiming at solving the problem of simply mixing betaine and organic acid in the prior art , the problem that the effect improvement is not obvious

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  • Eutectic of betaine and organic acid as well as preparation method and application of eutectic
  • Eutectic of betaine and organic acid as well as preparation method and application of eutectic
  • Eutectic of betaine and organic acid as well as preparation method and application of eutectic

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preparation example Construction

[0028] Such as Figure 4 Shown, the preparation method of the eutectic of a kind of betaine of the present invention and organic acid comprises the following steps:

[0029] Step S100, providing betaine and an organic acid, and mixing the betaine and the organic acid to obtain a mixture; wherein, the melting point of the organic acid is lower than that of the betaine.

[0030] Specifically, betaine is specifically betaine, or glycine trimethylamine inner salt, and organic acid refers to an organic compound containing a carboxyl group in the molecule.

[0031] The structural formula of betaine is as follows:

[0032] Organic acids include: one or more of azelaic acid, succinic acid, adipic acid, sebacic acid, acetic acid, oleic acid, linoleic acid and lactic acid. The structural formula of 1,9-azelaic acid is as follows: The structural formula of succinic acid is as follows: The structural formula of adipic acid is as follows: The structural formula of sebacic acid is ...

specific Embodiment 1

[0055] A preferred method for the preparation of betaine 1,9-azelaic acid co-crystal: Step 1: Weigh 0.01mol of betaine and 1,9-azelaic acid, place them in a reactor, and feed into the reactor An inert gas protects the reaction. After the reactor is sealed, the temperature is slowly raised to 95° C., and after 2 hours of reaction, the temperature of the reactor is naturally lowered, and cooled to room temperature to obtain the crude betaine 1,9-azelaic acid eutectic product. Second step: recrystallization of the crude eutectic product. Using methanol as a solution (ratio of 10ml to 1g), dissolve the betaine 1,9-azelaic acid eutectic, after complete dissolution, filter the membrane to remove impurities in the crude product. Concentrate the eutectic solution after impurity removal to a supersaturated state (with the volume of about 4 / 5 of the solution evaporated as a reference). Place the supersaturated solution at a low temperature of 2-5°C and wait for crystallization. Final...

specific Embodiment 2

[0088] A method for preparing betaine 1,9-azelaic acid co-crystal: Step 1: Weigh 0.01 mol of betaine and 1,9-azelaic acid and place them in a reactor. Introduce argon gas so that the whole reaction is carried out under an inert gas atmosphere, raise the temperature of the sealed reactor to 80°C, react for 6 hours, let the reactor cool down naturally, and cool to room temperature to obtain betaine 1,9-azelaic acid co- crystal solution. Second step: recrystallization of the crude eutectic product. Dissolve the betaine 1,9-azelaic acid eutectic in ethyl acetate as a solution (ratio of 10ml to 1g). After complete dissolution, filter the membrane to remove impurities in the crude product. Concentrate the eutectic solution after impurity removal to a supersaturated state (with the volume of about 4 / 5 of the solution evaporated as a reference). Place the supersaturated solution at a low temperature of 2-5°C and wait for crystallization. Finally, the eutectic product is filtered, t...

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Abstract

The invention discloses a betaine and organic acid eutectic crystal as well as a preparation method and application thereof, and the method comprises the following steps: providing betaine and organicacid, and uniformly mixing betaine and organic acid to obtain a mixture, wherein the melting point of the organic acid is smaller than that of the betaine; and stirring, heating and melting the mixture in an inert atmosphere, cooling the mixture to room temperature after the reaction is finished, and purifying the reaction product to obtain the eutectic crystal of betaine and organic acid. The organic acid and the betaine are adopted to form the eutectic crystal, the comprehensive effect of the obtained eutectic crystal of the betaine and the organic acid is good, the eutectic crystal of theorganic acid and the betaine is formed by adopting a heating melting method, and the stability of the obtained eutectic crystal of the betaine and the organic acid is high; and due to the adoption ofthe organic acid with a low melting point, the heating melting temperature is reduced, and preparation difficulty is reduced.

Description

technical field [0001] The invention relates to the technical field of eutectic, in particular to a eutectic of betaine and organic acid, a preparation method and application thereof. Background technique [0002] Betaine is a quaternary ammonia-type water-soluble alkaloid derived from sugar beet, which widely exists in nature. Because betaine plays a very important role in biological metabolism, it has been added to animal feed mainly as a nutritional enhancer in the past 50 years. As an organic osmotic substance, betaine can be used to balance cell volume and cell water content, and play a unique role in moisturizing and protecting cell performance. In the prior art, organic acids are used to improve the comprehensive effect of betaine. However, betaine Simply mixed with organic acid, the effect is not obvious. [0003] Therefore, the prior art still needs to be improved and developed. Contents of the invention [0004] The technical problem to be solved by the presen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/12C07C227/18C07C51/41C07C51/42C07C51/43C07C55/18A61K31/205A61P29/00A61P27/02A61P39/06A61K8/44A61K8/362A61K8/36A61K8/365A61Q19/02A61Q19/08A61Q19/00
CPCC07C229/12C07C227/18C07C51/412C07C51/42C07C51/43C07C55/18A61P29/00A61P27/02A61P39/06A61K8/44A61K8/362A61K8/36A61K8/361A61K8/365A61Q19/02A61Q19/08A61Q19/00C07B2200/13
Inventor 王振元张嘉恒王密李嘉奇王天晓李雪云干瑞靖吴称玉
Owner SHENZHEN SHINESKY BIOLOGICAL TECH CO LTD
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