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A kind of bifidobacterium powder and the preparation technology of probiotics thereof

A technology of bifidobacteria and probiotics, applied in the directions of bifidobacteria, microorganism-based methods, biochemical equipment and methods, etc., can solve the problems of complex preparation process and low survival rate of bifidobacteria, so as to improve the survival rate, Produce maneuverable, fast-acting results

Active Publication Date: 2022-04-15
广东长兴生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a kind of spray drying process of bifidobacteria powder, which has the advantages of high survival rate of bifidobacteria and good fluidity and formability of the dried powder, which solves the problems in the prior art. The survival rate of bifidobacteria after spray drying is low, and the follow-up preparation process is complicated

Method used

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  • A kind of bifidobacterium powder and the preparation technology of probiotics thereof
  • A kind of bifidobacterium powder and the preparation technology of probiotics thereof
  • A kind of bifidobacterium powder and the preparation technology of probiotics thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Bifidobacterium species: Chr. Hansen BB-12.

[0040] Inoculate Bifidobacterium BB-12 in TPY medium with 5% inoculation amount, and culture it at 37±1°C for 24 hours under anaerobic conditions, then at 4°C, 6000r·min -1 Centrifuge for 15 minutes, discard the supernatant, wash the cells with sterilized distilled water, and then centrifuge again under the same conditions to obtain bifidobacteria cells.

[0041] The obtained bacterial cells and the dry protection agent were mixed uniformly according to the weight-to-volume ratio (1:100g / mL). The formula of the above-mentioned spray-drying matrix is: 10g of skim milk powder, 7g of maltose by weight, 1.5g of calcium hydrogen phosphate, 0.4g of poloxamer, and 81.1g of water.

[0042] Spray-dry the mixed liquid obtained in the previous step. The spray-dried conditions are as follows: the bacterial cell mixed liquid is dried by a spray dryer at a speed of 5ml / min, the inlet temperature is 140°C, and the outlet temperature is 55°C...

Embodiment 2

[0045] The formulation of the spray-drying matrix is: 10 g of skimmed milk powder, 7 g of trehalose by weight, 1.5 g of calcium hydrogen phosphate, 0.4 g of poloxamer, and 81.1 g of water. Other operating conditions are with embodiment 1. Bifidobacteria survival rate: 52.8%.

Embodiment 3

[0047] The formulation of the spray-drying matrix is: 10 g of skimmed milk powder, 7 g of sucrose by weight, 1.5 g of calcium hydrogen phosphate, 0.4 g of poloxamer, and 81.1 g of water. Other operating conditions are with embodiment 1. Bifidobacteria survival rate: 55.3%.

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Abstract

The invention discloses a bifidobacterium powder and a preparation process of probiotics thereof. A protective matrix comprising maltose, calcium hydrogen phosphate and poloxamer is selected, and the bacterial body is mixed with the matrix before spray drying to increase the bifidobacterium production rate. Heat resistance and stress resistance, thereby significantly improving the survival rate of bifidobacteria spray drying; not only can it play a role in improving the survival rate of bifidobacteria, but also can make the bifidobacteria powder obtained after drying have good fluidity, which is convenient for subsequent preparations processing. Using the bifidobacterium powder prepared by the present invention as raw material, adding appropriate amount of milk powder, inulin, mannitol and silicon dioxide as auxiliary materials, using modern industrial technology to make a single-dose packaged powder, which has the advantages of convenient taking, rapid onset of action, and good taste. It has the characteristics of good alcohol, easy storage, accurate measurement, etc., and the preparation process is simple, the production operability is strong, the cost is low, and it is suitable for industrialized large-scale production.

Description

technical field [0001] The invention relates to a preparation process of bifidobacterium powder and a preparation process of probiotics containing the powder. Background technique [0002] Probiotics refer to microecological preparations that maintain the balance of the flora in the human body and have beneficial effects on human health. Taking a sufficient amount of active probiotics orally can help relieve acute and chronic gastroenteritis, treat diarrhea, improve digestion, and relieve symptoms such as lactose intolerance. Bifidobacterium is a common probiotic, and its bacterial preparations are divided into liquid preparations and solid preparations. The former is cultured through traditional fermentation and finally obtains the bifidobacterium liquid as a preparation product, while the latter is processed into a solid preparation form by means of freeze-drying, spray-drying or embedding after probiotics are multiplied. Liquid preparations are prone to contamination or...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A23L29/00A23L33/135A23G3/36A23G1/42A23C9/123C12R1/01
CPCC12N1/20A23L29/065A23L33/135A23C9/1234A23G3/366A23G1/423A23V2002/00A23V2400/51A23V2200/30
Inventor 林楚雄黄敏鑫陈晓玲卢君刘英敏李国伟曾维芬何彩霞
Owner 广东长兴生物科技股份有限公司
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