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Skin wound repair plaster loaded with cell regulatory factor and preparation method of skin wound repair plaster

A technology for regulating factors and skin wounds, applied in the field of medical excipients, can solve the problems of inability to promote wound healing, inability to achieve precise control of cell growth genes, and inability to precisely regulate wound cell growth, etc., and achieve excellent physical and chemical properties and good biocompatibility. The effect of the properties and the simple preparation method

Inactive Publication Date: 2021-02-09
GUANGDONG POLYTECHNIC OF IND & COMMERCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it cannot precisely regulate the growth of wound cells
[0008] In summary, there are generally technical defects in the prior art, such as the inability to promote wound healing and the inability to realize precise control of cell growth genes.

Method used

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  • Skin wound repair plaster loaded with cell regulatory factor and preparation method of skin wound repair plaster
  • Skin wound repair plaster loaded with cell regulatory factor and preparation method of skin wound repair plaster

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1, a preparation method of a skin wound repair application loaded with cell regulatory factors

[0037] The preparation method of the skin wound surface repair patch loaded with cell regulatory factors comprises the following steps:

[0038] S1. Inhale the configured electrospinning precursor solution into a syringe fixed on the propulsion pump to carry out the electrospinning process. The electrospinning process is: the propulsion rate of the propulsion pump is 1.5 ml / hour and the flow rate of the spinning solution is kept stable; The spinning nozzle is a flat needle with a diameter of 0.1 mm, which is connected to the positive electrode of a high-voltage DC power supply of 15 kV. The distance between the spinning nozzle and the collecting electrode is 10 cm. The relative humidity of the spinning environment is 40%, and the temperature is 25 ° C. Then vacuum dry 24h, remove the organic solvent that is not completely volatilized, and make a polymer fiber film...

Embodiment 2

[0043] Example 2, a preparation method of a skin wound repair patch loaded with cell regulatory factors

[0044] The preparation method of the skin wound surface repair patch loaded with cell regulatory factors comprises the following steps:

[0045] S1. Inhale the configured electrospinning precursor solution into a syringe fixed on the propulsion pump to carry out the electrospinning process. The electrospinning process is: the propulsion rate of the propulsion pump is 2.0 ml / hour and the flow rate of the spinning solution is kept stable; The spinning nozzle is a flat needle with a diameter of 0.3 mm, which is connected to the positive pole of a high-voltage DC power supply of 25 kV. The distance between the spinning nozzle and the collecting electrode is 10 cm. The relative humidity of the spinning environment is 55%, and the temperature is 25 ° C. Then vacuum dry 24h, remove the organic solvent that is not completely volatilized, and make a polymer fiber film;

[0046] S2...

Embodiment 3

[0050] Example 3, a preparation method of a skin wound repair application loaded with cell regulatory factors

[0051] The preparation method of the skin wound surface repair patch loaded with cell regulatory factors comprises the following steps:

[0052] S1. Inhale the configured electrospinning precursor solution into a syringe fixed on the propulsion pump to carry out the electrospinning process. The electrospinning process is: the propulsion rate of the propulsion pump is 1.7 ml / hour and the flow rate of the spinning solution is kept stable; The spinning nozzle is a flat needle with a diameter of 0.2 mm, which is connected to the positive electrode of a high-voltage DC power supply of 21 kV. The distance between the spinning nozzle and the collecting electrode is 10 cm. The relative humidity of the spinning environment is 51%, and the temperature is 25 ° C. Then vacuum drying 24h, remove the organic solvent that is not completely volatilized, and make a polymer fiber film...

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PUM

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Abstract

The invention belongs to the technical field of medical auxiliary materials, and particularly relates to a skin wound repair plaster loaded with a cell regulatory factor and a preparation method of the skin wound repair plaster. The preparation method comprises the following steps: firstly, preparing a polymer fiber film through electrostatic spinning, then adding bioactive glass, a plasmid DNA recombinant solution, gelatin and a photoinitiator into a phosphate buffer solution, and performing ultrasonic dispersion to obtain mixed slurry; and pouring the mixed slurry into a mold with a polymerfiber film paved at the bottom, initiating a free radical polymerization reaction under ultraviolet illumination, swelling a reaction product in a phosphate buffer solution to remove unreacted monomers and photoinitiators, and finally obtaining the skin wound repair plaster loaded with the cell regulatory factor. The skin wound repair plaster loaded with the cell regulatory factor has good biological activity, can be used for clinical skin wound treatment, and realizes repair and regeneration of skin tissue.

Description

technical field [0001] The invention belongs to the technical field of medical auxiliary materials, and in particular relates to a skin wound repair plaster loaded with cell regulatory factors and a preparation method thereof. Background technique [0002] In recent years, the use of biomedical materials to repair and replace skin tissue has become an important means of treating various acute and chronic skin injuries caused by trauma, burns, scalds, chemical corrosion, bacterial and viral infections, and environmental pollution. . Traditional skin wound dressings are mainly composed of cotton, soft linen, gauze and other materials, which are characterized by good water absorption, which can keep the wound dry, but cannot effectively prevent the wound from being infected. Moreover, traditional dressings tend to adhere to the wound surface, and it is likely to damage the newly recovered wound surface again when it is removed. The polymer film of synthetic skin wound dressin...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/32A61L15/18A61L15/44A61L15/28A61L15/40A61L15/46A61L15/20D04H1/4382D04H1/728
CPCA61L15/18A61L15/20A61L15/26A61L15/28A61L15/32A61L15/40A61L15/44A61L15/46A61L2300/112A61L2300/232A61L2300/236A61L2300/252A61L2300/258A61L2300/404A61L2300/418D04H1/4382D04H1/728C08L89/00C08L67/04C08L5/08
Inventor 原波何显运丘永亮
Owner GUANGDONG POLYTECHNIC OF IND & COMMERCE
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