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Sugar-free weeping forsythia leaf granules as well as preparation method and application thereof

A technique for forsythia leaves and granules, which is applied in the field of sugar-free forsythia granules and its preparation, can solve the problems of side effects, high price, complicated preparation process, severe liver damage, etc., and achieves convenience in taking, simple preparation process, store simple effects

Pending Publication Date: 2021-01-15
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Common slimming drugs mainly have the following defects: (1) side effects; (2) complex preparation process; (3) high price, difficult to popularize; ie rebound
For example, orlistat can bring side effects such as diarrhea, flatulence, and urgent stool, and relevant literature also shows that it can cause severe liver damage, acute kidney injury, etc.; lorcaserin, topiramate, and bupropion hydrochloride compound sustained-release tablets directly Acts on the nervous system, has relatively large side effects, and can cause tumors, suicidal tendencies, and cardiovascular and cerebrovascular diseases

Method used

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  • Sugar-free weeping forsythia leaf granules as well as preparation method and application thereof
  • Sugar-free weeping forsythia leaf granules as well as preparation method and application thereof
  • Sugar-free weeping forsythia leaf granules as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] [Example 1] Preparation and granulation of forsythia leaf water extract

[0030] S1. Weigh forsythia leaves, add distilled water to heat and reflux to extract, filter, combine the filtrate, and concentrate to a certain ratio to obtain a concentrated solution, such as figure 1 shown, or dry the concentrate to obtain a concentrated dry powder, such as figure 2 shown;

[0031] S2. After the concentrated solution is mixed with auxiliary materials and aspartame, wet granulation is performed, or after the concentrated liquid dry powder is mixed with auxiliary materials and aspartame, an appropriate amount of ethanol solution is added for wet granulation;

[0032] S3. The prepared granules are sieved and dried to obtain Forsythia leaf weight-loss granules, such as Figure 8 shown;

[0033] Among them, in S1, forsythia leaves are fresh forsythia leaves or dried forsythia leaves, distilled water is added 0.5-30 times, extraction times are 1-3 times, extraction time is 0.5-3 ...

Embodiment 2

[0036] [Example 2] Preparation and granulation of Forsythia leaf ethanol solution (concentration is 0-100%) extract

[0037] S1. Weigh forsythia leaves, add ethanol aqueous solution to heat and reflux to extract, filter, combine filtrates, and concentrate to a certain ratio to obtain a concentrated solution or dry the concentrated solution to obtain a concentrated dry powder;

[0038] S2. After the concentrated solution is mixed with auxiliary materials and aspartame, wet granulation is performed, or after the concentrated liquid dry powder is mixed with auxiliary materials and aspartame, an appropriate amount of ethanol solution is added for wet granulation;

[0039] S3. The prepared granules are sieved and dried to obtain the forsythia leaf weight-loss granules;

[0040] Wherein, in S1, the Forsythia leaves are fresh Forsythia leaves or dried Forsythia leaves, add 0.5-30 times of ethanol aqueous solution, the concentration of ethanol aqueous solution is 0-100% by weight, the...

Embodiment 3

[0043] [Example 3] Screening of granule auxiliary materials

[0044] Forsythia leaf extract has high viscosity, strong hygroscopicity, and is easy to agglomerate. The soft material is wet and soft when directly granulated, and the molding rate is low. In order to reduce its hygroscopicity and make it easier to granulate, it is necessary to add appropriate amount of excipients to improve it. Choose excipients commonly used in sugar-free granules, which are helpful for granule formation, dissolution and low hygroscopicity. Therefore, soluble starch, maltodextrin, and β-ring Common excipients such as dextrin and microcrystalline cellulose were compared and screened. The above excipients and forsythia leaf extract were granulated in different proportions and in different combinations, and then placed in an oven at 40°C for 30 minutes to fully dry the granules, and spread them flat on the bottom of a weighing bottle with a constant weight, with a thickness of about 2mm. Weigh it, ...

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Abstract

The invention discloses sugar-free weeping forsythia leaf granules as well as a preparation method and application thereof. The sugar-free weeping forsythia leaf granules comprise the following ingredients: microcrystalline cellulose, weeping forsythia leaf dry powder, and aspartame, and more specifically, based on the total weight of the sugar-free weeping forsythia leaf granules, the contents ofthe ingredients are as follows: 50-75 wt% of the microcrystalline cellulose, 25-50 wt% of the weeping forsythia leaf dry powder, and 0-1.5 wt% of the aspartame. The sugar-free weeping forsythia leafgranules disclosed by the invention are simple in preparation process, low in cost, and remarkable in weight reducing and blood lipid reducing effects; and moreover, the sugar-free weeping forsythia leaf granules can be taken for a long time without stopping the medication to cause weight regain.

Description

technical field [0001] The invention belongs to the field of food, and in particular relates to a sugar-free forsythia granule and a preparation method and application thereof. Background technique [0002] Obesity has become a global epidemic and is one of the major drivers of chronic disease and disability. According to WHO data, in 2016, 39% of adults aged 18 and over in the world, or 1.9 billion adults, were overweight, of which 13%, or 650 million adults, were obese. Obesity is a major risk factor for many serious diseases, such as 57% of non-insulin-dependent (type II) diabetes, 30% of gallbladder disease, 17% of coronary heart disease, 17% of hypertension, 14% of osteoarthritis, 11% of of breast / uterine / colon / rectum cancers are all related to obesity. At least 2.8 million deaths each year can be attributed to being overweight or obese. [0003] Common slimming drugs mainly have the following defects: (1) side effects; (2) complex preparation process; (3) high price...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/24A23L33/105A23P10/20
CPCA23L33/24A23L33/105A23P10/20A23V2002/00A23V2200/332A23V2200/3262A23V2250/082A23V2250/21A23V2250/2482A23V2250/51084A23V2250/5112A23V2250/5118A23V2300/14A23V2300/10A23V2300/50
Inventor 陈廷贵张磊张立伟
Owner SHANXI UNIV
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