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Multifunctional natural polysaccharide repair adhesive hydrogel, preparation method and application thereof in preparation of drugs for treating skin injury

A natural polysaccharide and multifunctional technology, applied in the field of material science, can solve the problems of sepsis and even osteomyelitis, and achieve the effect of shortening the gelation time, no biological toxicity, and simple modification steps

Active Publication Date: 2021-01-12
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in people's daily life, skin cuts and burns are almost inevitable, and open wounds can easily lead to sepsis and even osteomyelitis. Preventing wound infection and promoting rapid wound repair are two major challenges in the field of trauma therapy

Method used

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  • Multifunctional natural polysaccharide repair adhesive hydrogel, preparation method and application thereof in preparation of drugs for treating skin injury
  • Multifunctional natural polysaccharide repair adhesive hydrogel, preparation method and application thereof in preparation of drugs for treating skin injury
  • Multifunctional natural polysaccharide repair adhesive hydrogel, preparation method and application thereof in preparation of drugs for treating skin injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: the preparation of the chitosan of catechol modification

[0030] Add 3g chitosan and 300mL, 1mol / L HCl into a 500mL Erlenmeyer flask, stir thoroughly for 2 days, and after fully dissolved, adjust the pH of the solution to 4.5 with 1mol / L NaOH to obtain solution A. Dissolve 2.17g of dihydroxyphenylpropionic acid in 25mL of deionized water, and slowly drop it into solution A after being fully dissolved. During this process, continuous stirring is required to obtain solution B. Take 2.48 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and dissolve it in 50 mL of water and ethanol solution (the volume ratio of water and ethanol is 1:1), and slowly Drop into solution B, adjust the pH of the solution to 5 with 1mol / L NaOH throughout the whole process, pour the reaction solution into a dialysis bag (cellulose, molecular weight cut-off 12000Da) after reacting for 8 hours, and dialyze with a hydrochloric acid solution of pH=4.5 at room temperature...

Embodiment 2

[0031] Example 2: Preparation of dextran modified by aldylation

[0032] Dissolve 4g of dextran in 320mL deionized water and stir to dissolve fully to obtain a dextran solution; dissolve 4.2g of sodium periodate in 80mL of deionized water to obtain a sodium periodate solution; add the sodium periodate solution to the glucose In the polysaccharide solution, the whole reaction was protected from light for 24 hours, and then poured into a dialysis bag (cellulose, with a molecular weight cut-off of 3500Da), dialyzed with deionized water at room temperature for 3 days, and replaced the deionized water 3 times a day. The dialysate was frozen in liquid nitrogen and then frozen. Dry and store at -80°C to obtain aldehyde-modified dextran.

Embodiment 3

[0033] Embodiment 3: the preparation of skin restoration adhesive

[0034] Get the catechol-modified chitosan 50mg that embodiment 1 obtains and be dissolved in 1mL PBS (phosphate buffered saline), obtain the catechol-modified chitosan solution; Get the formylation modification that embodiment 2 obtains 50 mg of dextran was dissolved in 1 mL of PBS (phosphate buffered saline) to obtain a dextran solution modified by aldylation; after the two were fully dissolved, 2.5 mg MgO was weighed and added to the dextran In the solution, after rapid mixing, use a 1mL syringe to draw respectively the chitosan solution modified by catechol and the dextran solution modified by aldylation, and then blend with a spiral needle to obtain the multifunctional natural polysaccharide of the present invention. The repair bonding hydrogel is then injected into damaged skin to repair the skin.

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Abstract

The invention relates to multifunctional natural polysaccharide repair adhesive hydrogel, a preparation method and application thereof in preparation of drugs for treating skin injury, and belongs tothe technical field of material science. Natural polysaccharide is used as a raw material, and functional group modification is performed on the natural polysaccharide to enhance the tissue adhesiveness of the natural polysaccharide; then magnesium oxide nanoparticles are added into an aldehyde-modified glucan solution in advance, so that the gelling time can be further shortened, and the antibacterial effect is enhanced; therefore, the repair adhesive hydrogel which has good biocompatibility and tissue adhesiveness and can effectively close wounds is constructed. The whole process is simple to operate, the raw materials are easy to obtain and low in price, and the natural polymer functional groups have good biocompatibility after being modified and are non-toxic and harmless to cells. Thepolysaccharide is subjected to catechol modification and aldehyde modification, so that the water solubility of chitosan is enhanced, the viscosity of a glucan solution is reduced, the gelation timeof the two-component gel is shortened, and the gel can be endowed with relatively strong tissue adhesion.

Description

technical field [0001] The invention belongs to the technical field of material science, and in particular relates to a multifunctional natural polysaccharide repairing adhesive hydrogel, a preparation method and its application in the preparation of medicines for treating skin damage. Background technique [0002] As the largest organ of the human body, the skin is the first barrier against external attacks and stimuli. However, in people's daily life, skin cuts and burns are almost inevitable, and open wounds can easily lead to sepsis and even osteomyelitis. Preventing wound infection and promoting rapid wound repair are two major challenges in the field of trauma therapy. Therefore, it is necessary to develop a skin repair adhesive that can effectively close wounds and prevent infection. [0003] Hydrogel is a kind of bulk-phase cross-linked hydrophilic polymer with high water content. Through rational design, functional groups can be inserted into the gel network struct...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/08C08L5/02C08K3/22C08B37/02C08B37/08A61K9/06A61K47/36A61P17/02A61P31/04A61K33/08
CPCA61K9/06A61K33/08A61K47/36A61P17/02A61P31/04C08B37/0021C08B37/003C08J3/075C08J2305/02C08J2305/08C08J2405/02C08J2405/08C08K2003/222C08K2201/011
Inventor 张俊虎唐晓铎李道伟孙漪涵杨柏
Owner JILIN UNIV
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