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Novel preparation method of functionalized porous magnetic microspheres

A technology of magnetic microspheres and porous microspheres, applied in the direction of coating, can solve the problems of uneven surface hydrophilicity and hydrophobicity, few functional groups, etc., to achieve rich surface functional groups, increased surface area, and uniform particle size distribution. Effect

Inactive Publication Date: 2021-01-05
南京赛纳宝纳米科技有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the above problems, the present invention discloses a novel preparation method of functionalized porous magnetic microspheres, which can effectively solve the problems of magnetic nuclei gathering on the surface, uneven hydrophilicity and hydrophobicity of the surface, and few functional groups in the preparation process of magnetic microspheres.

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  • Novel preparation method of functionalized porous magnetic microspheres
  • Novel preparation method of functionalized porous magnetic microspheres
  • Novel preparation method of functionalized porous magnetic microspheres

Examples

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Effect test

Embodiment 1

[0029] (1) Preparation of seed microspheres. In this example, polystyrene microspheres were prepared by soap-free emulsion polymerization. The specific synthesis method is as follows:

[0030] 1) Add 500mL deionized water and 50mL styrene to a 1L three-necked flask, and stir for 10 minutes at room temperature under nitrogen gas at a speed of 200rpm;

[0031] 2) Add 1.0g of potassium persulfate to 50mL of deionized water, and ultrasonically dissolve;

[0032] 3) Pour the potassium persulfate solution into (1), raise the temperature to 80°C, and stir at 200rpm for 24 hours.

[0033] The scanning electron microscope images of the prepared styrene seed microspheres are as follows: figure 1 As shown, the particle size of the seed microspheres is 700 nm.

[0034] (2) Preparation of porous microspheres. In this example, glycidyl methacrylate was used as a functional monomer, cyclohexanol was used as a porogen, SDS was used as an emulsifier, PVP-K30 was used as a stabilizer, and BP...

Embodiment 2

[0047] (1) Preparation of seed microspheres. In this example, polyglycidyl methacrylate microspheres were prepared by soap-free emulsion polymerization. The specific synthesis method is as follows:

[0048] 1) Add 600mL deionized water and 30mL glycidyl methacrylate into a 1L three-necked flask, stir at room temperature for 10 minutes under nitrogen gas, and rotate at 200rpm;

[0049] 2) Add 0.8g of potassium persulfate to 36mL of deionized water, and ultrasonically dissolve;

[0050] 3) Pour the potassium persulfate solution into (1), raise the temperature to 75°C, and stir at 200rpm for 24 hours.

[0051] (2) Preparation of porous microspheres. In this example, methyl acrylate was used as a functional monomer, n-octanol was used as a porogen, SDS was used as an emulsifier, PVP-K30 was used as a stabilizer, and AIBN was used as an initiator , to prepare porous microspheres, the specific method is as follows:

[0052] 1) Weigh 2gSDS, 1.2gPVP-K30 in water, configure 200mL so...

Embodiment 3

[0064] (1) Preparation of seed microspheres. In this example, polystyrene microspheres were prepared by soap-free emulsion polymerization. The specific synthesis method is as follows:

[0065] 1) Add 500mL deionized water and 50mL styrene to a 1L three-necked flask, and stir for 10 minutes at room temperature under nitrogen gas at a speed of 200rpm;

[0066] 2) Add 1.0g of potassium persulfate to 50mL of deionized water, and ultrasonically dissolve;

[0067] 3) Pour the potassium persulfate solution into (1), raise the temperature to 80°C, and stir at 200rpm for 24 hours.

[0068] (2) Preparation of porous microspheres. In this example, glycidyl methacrylate was used as a functional monomer, cyclohexanol was used as a porogen, SDS was used as an emulsifier, PVP-K30 was used as a stabilizer, and BPO For initiator, prepare porous microsphere, concrete method is as follows:

[0069] 1) Weigh 0.23gSDS, 2gPVP-K30 in water, prepare 200mL solution, stir to dissolve, and it is solu...

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Abstract

The invention provides a novel preparation method of functionalized porous magnetic microspheres. The novel preparation method comprises the following steps: firstly, preparing seed microspheres withuniform particle size through polymerization reaction; secondly, preparing porous microspheres with functional groups on the surfaces by adopting a seed polymerization method, and thirdly, modifying the porous microspheres to enable the surfaces to be charged; then preparing magnetic nanoparticles with controllable particle sizes and charges or hydrophilic and hydrophobic surfaces, mixing the surface-modified porous microspheres with the magnetic nanoparticles with charges or hydrophilic and hydrophobic surfaces, enabling the charges on the surfaces of the porous microspheres to be opposite tothose on the surfaces of the magnetic nanoparticles through pH adjustment, and through electrostatic interaction, adsorbing a layer of magnetic nanoparticles in pore channels of the porous microspheres, and then synthesizing a functionalized shell layer on the surfaces of the porous magnetic microspheres, so as to prepare functionalized porous magnetic microspheres; the functionalized porous magnetic microspheres prepared by the method have the characteristics of uniform particle size, consistent magnetic content and rich surface functional groups.

Description

technical field [0001] The invention belongs to the field of material chemical industry, and in particular relates to a novel preparation method of functionalized porous magnetic microspheres. Background technique [0002] As a new type of nanomaterial, magnetic microsphere is the most widely cited core raw material in the field of in vitro diagnostics. It is a spherical magnetic material with a particle size of several hundred nanometers to several microns combined by inorganic magnetic materials and organic polymers. On the one hand, functional groups can be introduced on the surface, coupled with antibodies, antigens or other biomolecules, and the quantitative analysis of the target can be achieved through immune reaction and high-sensitivity detection methods; on the other hand, because the magnetic microspheres have a convenient magnetic field Therefore, when magnetic microspheres are used as carriers instead of traditional multi-well plates or other solid-phase carrier...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F285/00C08F220/06C08J9/36C08J9/28C08K9/04C08K3/22C08L51/00
CPCC08F285/00C08J9/36C08J9/28C08K9/04C08K3/22C08K2003/2265C08J2351/00C08F220/06
Inventor 杨良嵘唐斌于杰淼邢慧芳向树云
Owner 南京赛纳宝纳米科技有限公司
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