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CoFe2O4/PVDF composite bone scaffold and preparation method thereof

A technology of bone scaffold and composite powder is applied in the field of CoFe2O4/PVDF composite bone scaffold and its preparation, which can solve the problems of no prepared bone scaffold, poor health, and difficulty in exerting the piezoelectric effect of the scaffold.

Active Publication Date: 2020-12-15
JIANGXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Based on this, the purpose of the present invention is in order to solve prior art, has not yet prepared CoFe 2 o 4 The bone scaffold compounded with PVDF cannot completely overcome the problem that the piezoelectric effect of the scaffold is difficult to exert due to poor health and inability to exercise in patients with bone defects.

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  • CoFe2O4/PVDF composite bone scaffold and preparation method thereof
  • CoFe2O4/PVDF composite bone scaffold and preparation method thereof
  • CoFe2O4/PVDF composite bone scaffold and preparation method thereof

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Embodiment 1

[0034] The CoFe proposed by the first embodiment of the present invention 2 o 4 The preparation method of / PVDF composite bone scaffold specifically comprises the following steps:

[0035] (1) Use an electronic balance to weigh 0.5g of CoFe 2 o 4 Powder, CoFe 2 o 4 The particle size of the powder is 40nm, and it is added to a three-necked beaker filled with 75mL of absolute ethanol solution, and it is pre-dispersed by mechanical stirring and ultrasonic dispersion, so as to obtain a uniform and stable CoFe 2 o 4 ethanol suspension in which CoFe 2 o 4 It is spinel cobalt ferrite;

[0036] (2) Utilize electronic balance to weigh 9.5g of PVDF powder, the particle diameter of PVDF powder is 80 μ m, join in the three-necked beaker that fills 100mL dehydrated alcohol solution, make it realize pre-dispersion by mechanical stirring and ultrasonic dispersion, And then obtain the ethanol suspension of uniform and stable PVDF;

[0037] (3) The ethanol suspension of PVDF was added...

Embodiment 2

[0044] The CoFe proposed by the second embodiment of the present invention 2 o 4 The preparation method of / PVDF composite bone scaffold specifically comprises the following steps:

[0045] (1) Use an electronic balance to weigh 1.5g of CoFe 2 o 4 Powder, CoFe 2 o 4 The particle size of the powder is 40nm, and it is added to a three-necked beaker filled with 75mL of absolute ethanol solution, and it is pre-dispersed by mechanical stirring and ultrasonic dispersion, so as to obtain a uniform and stable CoFe 2 o 4 ethanol suspension;

[0046] (2) Utilize the electronic balance to weigh 8.5g of PVDF powder, the particle diameter of PVDF powder is 80 μ m, join in the three-necked beaker that fills 100mL absolute ethanol solution, make it realize pre-dispersion by mechanical stirring and ultrasonic dispersion, And then obtain the ethanol suspension of uniform and stable PVDF;

[0047] (3) The ethanol suspension of PVDF was added dropwise to CoFe 2 o 4 in ethanol suspension...

Embodiment 3

[0053] The CoFe proposed in the third embodiment of the present invention 2 o 4 The preparation method of / PVDF composite bone scaffold specifically comprises the following steps:

[0054] (1) Use an electronic balance to weigh 2.5g of CoFe 2 o4 Powder, CoFe 2 o 4 The particle size of the powder is 40nm, and it is added to a three-necked beaker filled with 75mL of absolute ethanol solution, and it is pre-dispersed by mechanical stirring and ultrasonic dispersion, so as to obtain a uniform and stable CoFe 2 o 4 ethanol suspension;

[0055] (2) Utilize electronic balance to weigh 7.5g of PVDF powder, the particle diameter of PVDF powder is 80 μm, join in the three-necked beaker that fills 100mL absolute ethanol solution, make it realize pre-dispersion by mechanical stirring and ultrasonic dispersion, And then obtain the ethanol suspension of uniform and stable PVDF;

[0056] (3) The ethanol suspension of PVDF was added dropwise to CoFe 2 o 4 in ethanol suspension, and th...

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Abstract

The invention relates to a CoFe2O4 / PVDF composite bone scaffold and a preparation method thereof. The CoFe2O4 / PVDF composite bone scaffold is prepared by the following steps: mixing and stirring ethanol suspension of CoFe2O4 and ethanol suspension of PVDF, performing solid-liquid phase separation on the obtained CoFe2O4 / PVDF mixed suspension, drying and ball-milling the obtained solid phase to obtain composite powder, and performing selective laser sintering on the composite powder. According to the CoFe2O4 / PVDF composite bone scaffold provided by the invention, remote non-contact electrical stimulation on bone cells can be realized by externally applying an alternating magnetic field, so that growth of osteoblasts and regeneration and reconstruction of defective tissues are promoted.

Description

technical field [0001] The invention relates to the technical field of artificial bone scaffolds, in particular to a CoFe 2 o 4 / PVDF composite bone scaffold and its preparation method. Background technique [0002] At present, artificial bone scaffolds have problems such as low bioactivity, bone regeneration, and slow osseointegration. It has been confirmed by research that the bone itself has piezoelectricity, and appropriate electrical stimulation can regulate the function of the cell membrane, activate cell pathways, and regulate the expression of bone-related genes in order to promote the adhesion of bone cells to the bone scaffold during bone repair. , Proliferation and differentiation, thereby accelerating bone regeneration and reconstruction. In addition, bio-piezoelectric materials can generate electric charges under the action of exogenous mechanical stress, and form the endogenous electrical microenvironment required to promote human bone growth, which is curre...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/02A61L27/50
CPCA61L27/16A61L27/025A61L27/50A61L2430/02C08L27/16
Inventor 戚方伟帅词俊杨友文刘国峰
Owner JIANGXI UNIV OF SCI & TECH
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