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A kind of water-soluble sponge with density gradient and preparation method and application thereof

A density gradient, water-soluble technology, applied in applications, medical formulations, surgery, etc., can solve the problems of high foam density, complicated preparation process, and difficult use of medical hemostatic materials

Active Publication Date: 2022-07-01
优尔爱(常州)医疗科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The foams prepared based on polyvinyl alcohol disclosed in the Chinese patents with patent publication numbers CN1289629 A, CN 1095075 A, CN 1557872 A and CN 1095387 A all involve the addition of aldehydes and acids, the production process is not environmentally friendly, and the products are not easy to be used as medical hemostasis material use
The Chinese patent with the patent publication number CN102827442 A discloses a preparation method of polyvinyl alcohol-polyurethane superabsorbent sponge. The superabsorbent sponge is obtained by blending and foaming polyvinyl alcohol aqueous solution and polyurethane, involving chemical reactions and organic tin The use of catalysts and complex processes, there are certain risks in the application of products in the field of medical hemostasis
The Chinese patent with the patent publication number of CN 108587016 A discloses a polyvinyl alcohol water-soluble foam plastic and its preparation method. The expandable masterbatch is obtained by extruding and granulating through a twin-screw extruder, and then microwave foaming process is adopted. Realize the preparation of water-soluble foam, the foam has a closed-cell structure, and the preparation process is relatively complicated. Although the product is water-soluble, the foam density is relatively high, and it is not easy to use as a medical hemostatic material

Method used

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  • A kind of water-soluble sponge with density gradient and preparation method and application thereof
  • A kind of water-soluble sponge with density gradient and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) 200 ml of a dispersion liquid containing 7% polyvinyl alcohol 1788 and 3% hydroxyethyl methyl cellulose was prepared. First, polyvinyl alcohol 1788 and hydroxyethyl methyl cellulose were added to deionized water containing 2% ethanol to swell for 24 hours, and then stirred for 6 hours at 60 °C under vacuum conditions of -0.095 MPa to obtain uniform dispersion A.

[0044] (2) Add 2% thickener AH-1509 to 50ml of water-based polyurethane AH-1618, and stir for 2 hours at room temperature under -0.095MPa vacuum to obtain uniform dispersion B.

[0045](3) Mix 200ml A and 50ml B, stir evenly at room temperature under -0.095MPa vacuum condition, then pour into a centrifuge tube and centrifuge at 10000r / min for 60s.

[0046] (4) Freeze the centrifuge tube containing the sample in step (3) at -25°C for 12h.

[0047] (5) Take out the thoroughly frozen sample, freeze-dry it at -80°C for 24 hours, and obtain a water-soluble sponge with a density gradient.

Embodiment 2

[0049] (1) 200 ml of an aqueous dispersion containing 10% of polyvinyl alcohol 1788 was prepared. First, polyvinyl alcohol 1788 was added to deionized water containing 2% ethanol to swell for 24 hours, and then stirred for 6 hours at 60°C under -0.095MPa vacuum to obtain uniform dispersion A.

[0050] (2) Add 2% thickener AH-1509 to 50ml of water-based polyurethane AH-1618, and stir for 2 hours at room temperature under -0.095MPa vacuum to obtain uniform dispersion B.

[0051] (3) Mix 200ml of dispersion A and 50ml of dispersion B, stir evenly at room temperature under -0.095MPa vacuum condition, then pour into a centrifuge tube and centrifuge at 12000r / min for 60s.

[0052] (4) Freeze the centrifuge tube containing the sample in step (3) at -25°C for 12h.

[0053] (5) Take out the thoroughly frozen sample, freeze-dry it at -80°C for 24 hours, and obtain a water-soluble sponge with a density gradient.

Embodiment 3

[0055] (1) 250 ml of an aqueous dispersion containing 10% of polyvinyl alcohol 1788 was prepared. First, polyvinyl alcohol 1788 was added to deionized water containing 2% ethanol to swell for 24 hours, and then stirred for 6 hours at 60°C under -0.095MPa vacuum to obtain uniform dispersion A.

[0056] (2) Add 2% thickener AH-1509 to 50ml of water-based polyurethane AH-1618, and stir for 2 hours at room temperature under -0.095MPa vacuum to obtain uniform dispersion B.

[0057] (3) Mix 250ml of dispersion A and 50ml of dispersion B, stir evenly at room temperature under -0.095MPa vacuum condition, then pour into a centrifuge tube and centrifuge at 6000r / min for 60s.

[0058] (4) Freeze the centrifuge tube containing the sample in step (3) at -25°C for 12h.

[0059] (5) Take out the thoroughly frozen sample, freeze-dry it at -80°C for 24 hours, and obtain a water-soluble sponge with a density gradient.

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Abstract

The invention discloses a preparation method of a water-soluble sponge with density gradient and its application in the field of nasal cavity hemostasis. The preparation method of the water-soluble sponge with density gradient includes the following steps: (1) preparing a polymer aqueous dispersion, denoted as dispersion A; (2) thickening the aqueous polyurethane dispersion, denoted as dispersion B; (3) ) Mix the dispersions A and B, and then pour it into a centrifuge tube for centrifugation; (4) quickly freeze the centrifuge tube containing the sample in step (3); (5) take out the thoroughly frozen sample for freeze-drying to obtain a Density gradient water soluble sponge. The sponge is particularly suitable for nasal surgery, used as a hemostatic material, and has the application effects of compression hemostasis, no adhesion, and water flushing ablation.

Description

technical field [0001] The invention relates to a preparation method and application of a water-soluble sponge with density gradient and belongs to the field of biomedical consumables. Background technique [0002] Foam materials are widely used in daily life and production. For example, flexible foam materials are widely used in electronics, automobiles, home furnishing, sports and leisure and other fields due to their cushioning, sound absorption, vibration isolation, heat preservation and filtration properties. Due to its light weight, high strength and flame retardant properties, it is widely used in construction, aerospace, rail transit, wind power and other fields. However, most of the foam materials in the above application fields are insoluble and degradable, which on the one hand are not environmentally friendly, and on the other hand cannot well meet the application requirements of specific fields. [0003] In the field of medical hemostatic materials, foam materi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/28C08L75/04C08L29/04C08L1/28C08L39/06A61L24/04A61L24/00
CPCC08J9/286C08J9/0061A61L24/0036A61L24/043C08J2201/0484C08J2375/04C08J2429/04C08J2401/28C08J2439/06C08J2207/10C08J2207/12A61L2400/04C08L1/284C08L29/04C08L75/04C08L39/06
Inventor 熊墨勇熊一男姜志国张均李丙军潘小帆万辉蒋国昌王爽
Owner 优尔爱(常州)医疗科技有限公司
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