Near-infrared exothermic acid-base responsive coaxial fiber for controlled release of doxorubicin hydrochloride and preparation method thereof
A doxorubicin hydrochloride, responsive technology, applied in the field of near-infrared exothermic acid-base responsive controlled-release doxorubicin hydrochloride coaxial fibers and preparation, can solve poor spinnability, unfavorable mechanical properties, structural integrity Instability and other problems, to achieve the effects of reducing toxicity, improving effective utilization, good human compatibility and organic polymer compatibility
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[0035] Such as figure 2 As shown, the preparation method of the coaxial fiber of the near-infrared exothermic acid-base response controlled-release doxorubicin hydrochloride of the present invention comprises the steps:
[0036](1), gelatin is placed in hexafluoroisopropanol, stirred and dissolved, poly-L-lactide-caprolactone is added, stirred and dissolved, then copper sulfide nanocrystals and saturated sodium bicarbonate solution are added, and stirring is continued to obtain Sheath fiber spinning solution;
[0037] (2), doxorubicin hydrochloride is dissolved in deionized water to obtain doxorubicin hydrochloride solution, i.e. the core drug solution;
[0038] (3), the shell fiber spinning solution is connected to the outer cavity of the coaxial spinning nozzle, and the doxorubicin hydrochloride solution is connected to the inner cavity of the coaxial spinning nozzle, and is sprayed through the coaxial spinning nozzle to carry out electrospinning, that is, simultaneously ...
Embodiment
[0045] The preparation method of the coaxial fiber of the near-infrared exothermic acid-base response controlled-release doxorubicin hydrochloride of the present embodiment comprises the following steps:
[0046] (1), dissolving gelatin in hexafluoroisopropanol at a ratio of 5% (w / v), stirring and dissolving continuously, adding 15% (w / v) poly-L-lactide-caprolactone, 3 % (w / v) copper sulfide nanocrystals and 5% (w / v) sodium bicarbonate saturated solution were sealed and dissolved in the dark, and the rotation speed was 600r / min, and the stirring was continued for 20min to obtain the shell fiber spinning solution.
[0047] (2) Dissolving doxorubicin hydrochloride in deionized water at a volume fraction of 1% to obtain a doxorubicin hydrochloride solution, that is, a core drug solution.
[0048] (3), such as image 3 As shown, the shell fiber layer spinning solution and the core drug solution are respectively advanced to the coaxial spinning nozzle 5 by setting corresponding in...
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