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Near-infrared exothermic acid-base responsive coaxial fiber for controlled release of doxorubicin hydrochloride and preparation method thereof

A doxorubicin hydrochloride, responsive technology, applied in the field of near-infrared exothermic acid-base responsive controlled-release doxorubicin hydrochloride coaxial fibers and preparation, can solve poor spinnability, unfavorable mechanical properties, structural integrity Instability and other problems, to achieve the effects of reducing toxicity, improving effective utilization, good human compatibility and organic polymer compatibility

Pending Publication Date: 2020-11-27
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, their poor spinnability, unfavorable mechanical properties of scaffolds prepared from them, and instability of their structural integrity in aqueous environments lead to stabilization of their structures by mixing or crosslinking with other polymers.

Method used

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  • Near-infrared exothermic acid-base responsive coaxial fiber for controlled release of doxorubicin hydrochloride and preparation method thereof
  • Near-infrared exothermic acid-base responsive coaxial fiber for controlled release of doxorubicin hydrochloride and preparation method thereof
  • Near-infrared exothermic acid-base responsive coaxial fiber for controlled release of doxorubicin hydrochloride and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0035] Such as figure 2 As shown, the preparation method of the coaxial fiber of the near-infrared exothermic acid-base response controlled-release doxorubicin hydrochloride of the present invention comprises the steps:

[0036](1), gelatin is placed in hexafluoroisopropanol, stirred and dissolved, poly-L-lactide-caprolactone is added, stirred and dissolved, then copper sulfide nanocrystals and saturated sodium bicarbonate solution are added, and stirring is continued to obtain Sheath fiber spinning solution;

[0037] (2), doxorubicin hydrochloride is dissolved in deionized water to obtain doxorubicin hydrochloride solution, i.e. the core drug solution;

[0038] (3), the shell fiber spinning solution is connected to the outer cavity of the coaxial spinning nozzle, and the doxorubicin hydrochloride solution is connected to the inner cavity of the coaxial spinning nozzle, and is sprayed through the coaxial spinning nozzle to carry out electrospinning, that is, simultaneously ...

Embodiment

[0045] The preparation method of the coaxial fiber of the near-infrared exothermic acid-base response controlled-release doxorubicin hydrochloride of the present embodiment comprises the following steps:

[0046] (1), dissolving gelatin in hexafluoroisopropanol at a ratio of 5% (w / v), stirring and dissolving continuously, adding 15% (w / v) poly-L-lactide-caprolactone, 3 % (w / v) copper sulfide nanocrystals and 5% (w / v) sodium bicarbonate saturated solution were sealed and dissolved in the dark, and the rotation speed was 600r / min, and the stirring was continued for 20min to obtain the shell fiber spinning solution.

[0047] (2) Dissolving doxorubicin hydrochloride in deionized water at a volume fraction of 1% to obtain a doxorubicin hydrochloride solution, that is, a core drug solution.

[0048] (3), such as image 3 As shown, the shell fiber layer spinning solution and the core drug solution are respectively advanced to the coaxial spinning nozzle 5 by setting corresponding in...

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Abstract

The invention provides a near-infrared exothermic acid-base responsive coaxial fiber for controlled release of doxorubicin hydrochloride and a preparation method, the coaxial fiber comprises a doxorubicin hydrochloride core layer and a shell fiber layer with a hollow structure, the shell fiber layer is prepared by spinning a shell fiber layer spinning solution, the shell fiber layer spinning solution is prepared by mixing poly L-lactide-caprolactone, gelatin, a sodium bicarbonate saturated solution and copper sulfide nanocrystals; the nanofiber with the near-infrared heat release doxorubicin hydrochloride chemotherapy function is designed through coaxial coating, the nanofiber reacts with hydrogen ions around a tumor affected part by combining a pH-sensitive drug sodium bicarbonate to generate carbon dioxide, pores are formed in the surface of the fiber during release, therefore, the efficient release of the doxorubicin hydrochloride in the core layer in the acidic environment of the tumor tissue is realized, and the controlled release effect is realized; the nano copper sulfide in the shell layer absorbs and converts near-infrared light penetrating through a human body into heat and oxygen, and the heat release treatment and drug chemotherapy have a synergistic effect, so that effective treatment of tumors is realized.

Description

technical field [0001] The invention belongs to the technical field of functional textiles, and in particular relates to a coaxial fiber with near-infrared exothermic acid-base response controlled-release doxorubicin hydrochloride and a preparation method. Background technique [0002] With the development of emerging disciplines such as biomedicine and material science, due to the intercrossing of various disciplines, the combination of pharmaceutical materials and textile fibers to prepare functional textiles with excellent sustained-release medical properties has become a research boom in the field of textile materials. The diameter of electrospun nanofibers is smaller than that of the cell domain, so it can simulate the framework and biological characteristics of the biomimetic extracellular matrix, and gather the nanofibers together to form a non-woven network that provides tensile strength and elasticity. It not only provides physical support for cells, but also provi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/34A61K47/42A61K31/704A61K41/00A61P35/00D01D5/00D01D5/34
CPCA61K9/0092A61K47/34A61K47/42A61K31/704A61K41/0052A61P35/00D01D5/0015D01D5/34A61K2300/00
Inventor 辛斌杰王蕾李庭晓袁蓉刘岩
Owner SHANGHAI UNIV OF ENG SCI
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