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An anion-cation co-doped nanometer calcium phosphate antibacterial material and preparation method thereof

A nano-calcium phosphate, anion and cation technology, used in pharmaceutical formulations, prostheses, drug delivery, etc., can solve problems such as difficulty in coordinating antibacterial ability and osteogenic activity

Active Publication Date: 2022-05-10
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obviously, single copper doped CaP is difficult to coordinate the balance between antibacterial ability and osteogenic activity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] a: Prepare 8mL of 0.1mol / L potassium dihydrogen phosphate solution, adjust the pH value to 7.0, and dilute to 10mL;

[0030] b: Mix 3.4mL 0.01mol / L copper nitrate solution with 8.6mL 0.1mol / L calcium nitrate solution and stir evenly;

[0031] c: Add the solution of step b to the solution of step a dropwise, stir and oscillate at 30°C, 200 rpm, and maintain the pH value at 11.0. After the titration, age at room temperature for one day, then wash and dry to obtain copper-containing phosphoric acid Calcium granules.

Embodiment 2

[0033] a: Prepare 6.0mL 2mmol / L diammonium hydrogen phosphate solution and adjust the pH value to 9.0;

[0034] b: Stir 1mL 2mmol / L magnesium chloride salt solution and 9mL 2mmol / L calcium chloride solution evenly;

[0035] c: Add the solution of step b to the solution of step a dropwise, stir and oscillate at 60°C, 600 rpm, and maintain the pH value at 9.0. After the titration is completed, age at room temperature for one day, then wash and dry to obtain magnesium-containing phosphoric acid Calcium particles

Embodiment 3

[0037] a: Prepare 5.2mL 1mmol / L disodium hydrogen phosphate solution, adjust the pH value to 10.0, and dilute to 10ml;

[0038] b: Mix 2mL 2mmol / L silver nitrate solution with 10mL 1mmol / L calcium nitrate, and stir evenly;

[0039] c: Add the solution of step b to the solution of step a dropwise, stir and oscillate at 45°C, 400 rpm, and maintain the pH value at 10.0. After the titration, age at room temperature for one day, then wash and dry to obtain silver-containing phosphoric acid Calcium granules.

[0040] Example 1

[0041] a: Add 1.2mL 0.1mol / L ammonium fluoride solution to 7.6mL 0.1mol / L potassium dihydrogen phosphate solution, adjust the pH value to 7.0;

[0042]b: Mix 3.4mL 0.01mol / L copper nitrate solution with 8.6mL 0.1mol / L calcium nitrate solution and stir evenly;

[0043] c: Add the solution of step b and 5mL of γ-polyglutamic acid modifier solution to the solution of step a dropwise at the same time, stir and oscillate at 30°C, 200 rpm, and maintain the pH v...

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PUM

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Abstract

The invention discloses an anion-cation co-doped nanometer calcium phosphate antibacterial material and a preparation method thereof. Anionic fluorine, γ-PGA, cationic copper, zinc, magnesium or silver ions are doped into the calcium phosphate crystal structure to form an anion-cation co-doped nano-calcium phosphate antibacterial material. The present invention adjusts the pH value through circulation, and adds a small amount of Cr to the γ-PGA solution 3+ , prepared as a γ‑PGA modifier, so that the Ca on γ‑PGA and calcium phosphate crystals 2+ Combination also occurs, so as to achieve the preparation of fluoride ion, γ-polyglutamic acid and metal ion anion and cation co-doped nano-calcium phosphate, which has good antibacterial properties, can regulate the degradation rate of metal ions and fluoride ions, and improve its anti-infection , promote angiogenesis, promote bone formation and other biological properties.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to an anion-cation-containing co-doped nanometer calcium phosphate antibacterial material and a preparation method thereof. Background technique [0002] The main mineral component of natural bone is calcium phosphorus compound (CaP), and synthetic CaP also has excellent biocompatibility and osteogenic properties. Researchers have proved that CaP has antibacterial activity after being doped with various ions (such as Ag, Zn, Mg, Cu, etc.), and CaP co-doped with multiple ions will show better synergy. Different mechanisms of action can not only improve its antibacterial ability, expand the scope of antibacterial to more pathogenic strains, but also reduce toxic and side effects. However, doped modified materials have both antibacterial and bone-promoting effects, and their mechanism of action is strongly related to the type of metal, doping amount, particle ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/18A61L27/02A61L27/54A61L27/58
CPCA61L27/12A61L27/18A61L27/025A61L27/54A61L27/58A61L2300/102A61L2300/404A61L2300/412A61L2300/604A61L2400/12A61L2430/02C08L77/04
Inventor 疏秀林廖俊达张丹丹王玲玲杨平施庆珊谢小保
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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