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Bone repair materials that can form 3D porous scaffolds in situ and their preparation and application

A porous scaffold, bone repair technology, applied in bone implants, pharmaceutical formulations, pharmaceutical science and other directions, can solve problems such as poor effect and implantation

Active Publication Date: 2021-05-18
福州瓷生科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since the bone defect is usually large, the corresponding large-sized porous scaffold material cannot be implanted by injection.
In this regard, researchers tried to add additives to bone cement to make holes in situ, but the effect was not good

Method used

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  • Bone repair materials that can form 3D porous scaffolds in situ and their preparation and application
  • Bone repair materials that can form 3D porous scaffolds in situ and their preparation and application
  • Bone repair materials that can form 3D porous scaffolds in situ and their preparation and application

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Embodiment Construction

[0011] Various aspects of the present invention will be described in detail below around the above-mentioned purpose of the present invention.

[0012] Unless otherwise specified, the abbreviations of some compounds used herein are shown in Table 1 below.

[0013] Table 1

[0014] bioactive ceramics Abbreviation bioactive ceramics Abbreviation CaSO 4 0.5H 2 o

wxya Ca 10 (PO 4 ) 6 (OH) 2

HA MgO-SiO 2

MS Ca 9 (HPO 4 )(PO 4 ) 5 (OH)

CDHA α-Ca 3 (PO 4 ) 2

α-TCP 3CaO SiO 2 / Ca 3 SiO 5

C 3 S

β-Ca 3 (PO 4 ) 2

β-TCP 2CaO SiO 2 / Ca 2 SiO 4

C 2 S

Ca(H 2 PO 4 ) 2 ·H 2 o

MCPM xCaO·SiO 2 ·nH 2 o

C-S-H CaHPO 4

DCPA Ca 2 P 2 o 7

CPP CaHPO 4 2H 2 o

DCPD

[0015]

[0016] The bone repair material of the present invention is obtained by using calcium sulfate hemihydrate and biologically active cer...

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Abstract

The invention discloses a bone repair material, which is obtained by taking calcium sulfate hemihydrate and bioactive ceramic materials as raw materials, mixing them uniformly, granulating them, and performing heat treatment. The bone repair material is injectable, suitable for minimally invasive surgery, can form a 3D porous scaffold with good mechanical strength in situ after injection, and has excellent performance in promoting bone repair and regeneration.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a bone repair material capable of forming a 3D porous scaffold in situ, a preparation method thereof, and an application in bone repair. Background technique [0002] Bone filling materials and osteoactive implants are currently the most commonly used materials for bone repair and regeneration in surgery. There are more than 2 million surgical operations worldwide each year that require the use of bone filling materials. Among all bone filling materials, autologous bone is most suitable for patients’ bone regeneration conditions, such as osteoconduction, osteoinduction, and osteogenesis, so it is considered to be the best material. Increase the additional pain of the patient. The use of allogeneic bone also accounts for a large market, such as bovine decalcified bone, but due to the uncontrollable source and potential disease infection, there are great con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/10A61L27/12A61L27/50A61L27/56A61L27/58A61F2/28A61F2/30
CPCA61F2/28A61F2/30942A61L27/10A61L27/12A61L27/50A61L27/56A61L27/58A61L2400/06A61L2430/02
Inventor 夏炜朱威翁习生
Owner 福州瓷生科技有限公司
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