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Application of radix tinosporae D-terpilenol in preparation of medicine for treating ulcerative colitis

A technology for ulcerative colitis and pinitol, applied in the direction of drug combination, ether/acetal active ingredients, pill delivery, etc., can solve problems such as unclear pathological mechanism

Inactive Publication Date: 2020-10-30
GUANGDONG ACAD OF FORESTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that there are many factors affecting UC, including environment, genetics, intestinal microorganisms, etc., but its pathological mechanism is still unclear
However, there is no relevant report on the use of pinitol for the treatment of ulcerative colitis

Method used

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  • Application of radix tinosporae D-terpilenol in preparation of medicine for treating ulcerative colitis
  • Application of radix tinosporae D-terpilenol in preparation of medicine for treating ulcerative colitis
  • Application of radix tinosporae D-terpilenol in preparation of medicine for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 (preparation example)

[0025] 1. Experimental materials

[0026] 1.1 Experimental drugs

[0027] Mulan fruit is collected from Nansha Wetland Park, Panyu District, Guangdong Province.

[0028] 1.2 Preparation of compounds

[0029] (1) Take the fruit of Mulan, pulverize it, add 10 times the amount of distilled water, heat and boil, extract 3 times, decoct for 2.5 hours each time, filter, combine the water extracts for three times, concentrate under reduced pressure until the solution is thick, and obtain Almond fruit extract;

[0030] (2) Pass the total extract of Mulan fruit through Rp-C 18 Reversed-phase silica gel column chromatography was used for separation, followed by elution with methanol with a concentration of 10%, methanol with a concentration of 30%, methanol with a concentration of 50%, methanol with a concentration of 70% and methanol with a concentration of 90%, and collected The methanol eluate with a concentration of 10% was concentrat...

Embodiment 2

[0041] Embodiment 2 (effect example)

[0042] 1. Experimental materials

[0043] 1.1 Experimental drugs

[0044] Dextran sulfate sodium (DSS) was purchased from MP Biomedical (Canada); Sulfasalazine (SASP) was purchased from Shanghai Xinyi Tianping Pharmaceutical Co., Ltd.

[0045] 1.2 Preparation of reagents and reagents

[0046] Preparation of 3% DSS solution: weigh 300g of DSS, dissolve in 1000ml of distilled water, and mix well; preparation of 200mg / kg SASP solution: take 6 sulfasalazine tablets, remove the coating, crush them, add 15ml of physiological Dissolve in saline, vortex and mix well; 10mg / kg, 20mg / kg and 40mg / kg pinitol solution preparation: Weigh 10mg, 20mg and 40mg of pinitol powder prepared in the above-mentioned Example 2, add 10ml physiological saline to dissolve respectively, Vortex to mix.

[0047] 1.3 Experimental Instruments

[0048] SHIMADZU analytical balance, Guangzhou Xiangyi Electromechanical Equipment Co., Ltd.; PL-203 electronic balance, Shan...

Embodiment 3

[0065] Embodiment 3 (medicine preparation example)

[0066] The pinitol used in the following examples 1-2 all adopts the pinitol D-pinitol prepared in Example 1.

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Abstract

The invention relates to an application of radix tinosporae D-terpilenol in preparation of a medicine for treating ulcerative colitis. The compound is obtained by carrying out water extraction and column chromatography separation and purification on a mangrove forest plant radix tinosporae. In the application, the medicine is prepared from terpilenol and medically acceptable auxiliary materials, wherein the mass percentage of D-terpilenol in the medicine is 20%-35%. The effect of treating ulcerative colitis by using the medicine is remarkable.

Description

technical field [0001] The invention relates to a medical preparation containing organic active ingredients, in particular to the inositol compound in the fruit of the mangrove plant Bruguiera gymnorrhiza, which can treat ulcerative colitis. Background technique [0002] Ulcerative colitis (UC) (Inflammatory bowel disease, IBD) is a common clinical gastrointestinal disease, mainly manifested as weight loss, diarrhea, abdominal pain and even blood in the stool, etc., and has the characteristics of long duration and repeated attacks. The severity of symptoms depends on the progression of the disease. Ulcerative colitis and Crohn's disease (Crohn's disease, CD) belong to two subtypes of inflammatory bowel disease (Inflammatory bowel disease, IBD). The recurrent attacks and lengthy disease process of ulcerative colitis usually lead to multiple complications, which are closely related to the pathogenesis of colon cancer. So far, the drugs for treating IBD mainly include aminosa...

Claims

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Application Information

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IPC IPC(8): A61K31/075A61K9/20A61K9/48A61P1/04
CPCA61K9/20A61K9/48A61K31/075A61P1/04
Inventor 高常军孙章华易小青蔡坚苏子仁林茵斯
Owner GUANGDONG ACAD OF FORESTRY
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