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Application of bruguiear gymnorrhiza fruit in preparation of drug for preventing and treating acute ulcerative colitis

A technology of ulcerative colitis and olive fruit, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of easy recurrence, difficult to cure, and application restrictions

Inactive Publication Date: 2019-08-02
GUANGDONG ACAD OF FORESTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many influencing factors and the pathogenesis of UC is complicated, and the research has not been clear. The World Health Organization believes that it is a disease that is difficult to cure
At present, UC can be controlled by drugs. Common clinical drugs for the treatment of UC mainly include classic anti-inflammatory drugs such as glucocorticoids, 5-aminosalicylic acid, immunosuppressants, and biological agents. However, the use of these drugs The treatment process is often accompanied by various side effects, such as fever, vomiting, Lyell syndrome, etc., and it is easy to relapse, so its clinical application is limited

Method used

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  • Application of bruguiear gymnorrhiza fruit in preparation of drug for preventing and treating acute ulcerative colitis
  • Application of bruguiear gymnorrhiza fruit in preparation of drug for preventing and treating acute ulcerative colitis
  • Application of bruguiear gymnorrhiza fruit in preparation of drug for preventing and treating acute ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 (effect example)

[0020] 1. Experimental materials

[0021] 1.1 Reagents

[0022] Dextran sulfate sodium (DSS) was purchased from MP (Canada) Biomedical Company; Sulfasalazine (SASP) was purchased from Shanghai Xinyi Tianping Pharmaceutical Co., Ltd.

[0023] 1.2 Preparation of reagents and reagents

[0024] Preparation of 3% DSS solution: Weigh 300g of DSS and add it to 1000ml distilled water, mix well; Preparation of 25mg / kg, 50mg / kg and 100mg / kg water extract solution of Mulan fruit: Weigh the following examples 2 Prepare 25mg, 50mg and 100mg of the water-extracted extract powder of Mulan fruit, add 10ml distilled water to dissolve respectively, and mix well; the preparation of 25mg / kg, 50mg / kg and 100mg / kg Mulan fruit alcohol extract solution: weigh Get 25mg, 50mg and 100mg of the Alkali fruit extract powder prepared in the following example 2, add 10ml of distilled water to dissolve respectively, and mix well; 200mg / kg SASP solution preparation: ta...

Embodiment 2

[0051] Embodiment 2 (medicine preparation example)

[0052] In the following preparation examples 1-4, the water-extracted extract powder of Mulan fruit used is all obtained by the following method:

[0053] Crush the fruit of Mulan, add 20 times the amount of water, heat and boil, extract twice, each time for 2.5 hours, filter, combine the two extracts, heat and concentrate to a thick paste, and freeze-dry to obtain Mulan fruit water Extract the extract powder, pack it separately, and store it in a refrigerator at 4°C.

[0054] Alcoholic extract powder used in the following preparation examples 5-8 all adopts the following method to make:

[0055] Pulverize the fruit of Mulan, add 20 times the amount of 60% ethanol in a water bath, heat and reflux for extraction twice, each time for 2.5 hours, combine the two extracts, concentrate under reduced pressure to a thick paste, and freeze-dry to obtain the alcohol extraction of Mulan fruit. The extract powder is stored in a refrig...

example 1

[0056] Example 1 prepares oral liquid

[0057] Weigh 100g of Mulan fruit water extract, add ethanol of appropriate concentration, and suitable additives such as stevioside and sorbic acid, mix well, and prepare 1000ml solution, filter and clarify, seal the contents, and sterilize. The net content of each bottle of oral liquid is 10mL, and contains 100mg of water extract of Mulan fruit. Orally, 3 times a day, 1 bottle each time, a course of treatment for 14 days.

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Abstract

The invention relates to application of a bruguiear gymnorrhiza fruit in preparation of a drug for preventing and treating ulcerative colitis. The bruguiear gymnorrhiza fruit disclosed by the invention has a good therapeutic effect on ulcerative colitis caused by sodium dextran sulfate (DSS), and can be used for preparing the drug for preventing and treating ulcerative colitis.

Description

technical field [0001] The present invention relates to medical preparations, in particular to medicines containing undetermined structures from plants of the genus Bruguiera, which are suitable for preventing and treating acute ulcerative colitis. Background technique [0002] Ulcerative colitis (Ulcerative colitis, UC) is a common intractable gastrointestinal disease, a subtype of inflammatory bowel disease (Inflammatory bowel disease, IBD). Its clinical manifestations are diarrhea, persistent mucus stools, abscesses, or bloody stools, depending on the severity of the disease. The repeated and lengthy disease course of UC often leads to multiple complications, even cancer. In recent years, the incidence of UC has been on the rise and tends to be younger, which has become an urgent problem to be solved. However, there are many influencing factors and the pathogenesis of UC is complicated, and the research has not been clear. The World Health Organization believes that it ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/00
CPCA61K36/185A61P1/00
Inventor 蔡坚苏子仁魏龙吴琰林茵斯罗丹丹陈金芬
Owner GUANGDONG ACAD OF FORESTRY
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