Application of azelaic acid in preparation of medicine for treating inflammatory bowel disease

A technology of inflammatory bowel disease and azelaic acid, which is applied in the field of medicine, can solve the problems that azelaic acid has not been found to treat inflammatory bowel disease, and achieve the effect of reducing colon shortening and weight loss

Pending Publication Date: 2022-03-22
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No reports of azelaic acid being used in the treatment of inflammatory bowel disease

Method used

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  • Application of azelaic acid in preparation of medicine for treating inflammatory bowel disease
  • Application of azelaic acid in preparation of medicine for treating inflammatory bowel disease
  • Application of azelaic acid in preparation of medicine for treating inflammatory bowel disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 24 healthy mice and divide them into 4 groups on average, 6 mice in each group, namely blank control group, DSS group, azelaic acid group, and DSS+azelaic acid group. The feeding method of the mice in the blank control group was: free drinking water and food intake. The feeding method of the mice in the DSS group was as follows: feeding with 2.5wt% DSS solution as the only water source, free food intake, and water as the solvent for DSS solution preparation. The feeding method of the mice in the azelaic acid group was as follows: free drinking water, free food intake, feeding (12.5mg / ml) azelaic acid solution every day, once a day, and feeding 0.2ml each time; azelaic acid solution The solvent during configuration is 0.9wt% physiological saline. The feeding method of the mice in the DSS + azelaic acid group was as follows: feeding with 2.5wt% DSS solution as the only water source, free food intake and regular feeding of 12.5 mg / ml azelaic acid solution every day, ...

Embodiment 2

[0038] The colon tissue of Example 1 was collected, and the content of GSH in the colon tissue of mice in each group was detected using a reduced glutathione (GSH) content detection kit. The result is as Figure 5 shown.

[0039] Figure 5 It was shown that compared with the DSS group, azelaic acid intervention can significantly increase the content of GSH in colitis mice, suggesting that azelaic acid may play an anti-inflammatory effect on IBD by activating the antioxidant system.

[0040] As can be seen from the above examples, the present invention provides the application of azelaic acid in the preparation of medicines for treating inflammatory bowel disease. The present invention uses azelaic acid for the first time in the preparation of medicines for treating inflammatory bowel diseases. By preparing DSS colitis model small In rats, it was found that azelaic acid can significantly slow down the weight loss caused by colitis, and alleviate the symptoms of colon shorteni...

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PUM

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Abstract

The invention provides application of azelaic acid in preparation of a medicine for treating inflammatory bowel disease, and relates to the technical field of medicine. The technical scheme of the invention comprises application of azelaic acid in preparation of drugs for treating inflammatory bowel diseases, wherein the inflammatory bowel diseases comprise colitis. The azelaic acid is used for preparing the medicine for treating the colitis for the first time and can remarkably relieve weight loss caused by the colitis and relieve the symptoms such as colon shortening, intestinal mucosa crypt structure damage, goblet cell loss and inflammatory cell infiltration degree caused by the colitis when being used for treating the colitis; the basis is provided for taking the azelaic acid as the medicine for treating the colitis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of azelaic acid in the preparation of medicines for treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (Inflammatory bowel disease, IBD), including Crohn's disease and ulcerative colitis, is a group of immune-related chronic relapsing intestinal inflammatory diseases, and its incidence and prevalence have increased in many parts of the world in recent years obviously increase. Prolonged uncontrolled inflammation can lead to serious complications such as fibrotic strictures, intestinal fistulas, and intestinal tumors. IBD seriously endangers human health, and the curative effect and prognosis of current drugs are poor. Therefore, it is of great clinical significance to explore new safe and effective targets for the pathogenesis and diagnosis and treatment of IBD. The pharmacological effects of azelaic acid include: (1)...

Claims

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Application Information

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IPC IPC(8): A61K31/194A61P1/00A61P29/00
CPCA61K31/194A61P1/00A61P29/00
Inventor 王晓艳廖洋洁黄禹君邓敏子马可嘉
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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