Traditional Chinese medicine composition for treating colon cancer and its preparation method and application

A technology of colon cancer and its composition, which is applied in the field of traditional Chinese medicine composition for the treatment of colon cancer and its preparation, and can solve the problems of not being able to satisfy chemotherapy patients and fundamentally improving the quality of life and survival rate of colon cancer patients

Active Publication Date: 2021-11-02
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obviously, the above-mentioned patents cannot meet the needs of chemotherapy patients, and cannot fundamentally improve the quality of life and survival rate of colon cancer patients

Method used

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  • Traditional Chinese medicine composition for treating colon cancer and its preparation method and application
  • Traditional Chinese medicine composition for treating colon cancer and its preparation method and application
  • Traditional Chinese medicine composition for treating colon cancer and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A traditional Chinese medicine composition for treating colon cancer, the main active ingredients of which include the following raw materials: Beiqi 30g, Xianlingpi 10g, Radix Paeoniae Rubra 15g, Curcuma zedoary 10g, Smilax tuckahoe 20g, and Stir-fried Atractylodes macrocephala 15g.

[0040]The above components are taken, and the traditional Chinese medicine decoction is prepared according to the existing preparation method of the traditional Chinese medicine decoction. The proportion is one dosage, and the dosage of one dosage is about 300mL.

[0041] The preparation method of the traditional Chinese medicine decoction is as follows: mix Beiqi, Xianlingpi, Chishao, Curcuma, Smilax, and Fried Atractylodes in parts by weight to obtain a mixture, and then add it into water according to the ratio of material to liquid at 1:10 and soak for 0.5 hours. Decocting for 0.5 h, filtering to obtain the first filtrate, decocting the filter residue once, combining the filtered filtra...

Embodiment 2

[0043] A traditional Chinese medicine composition for treating colon cancer, the main active ingredients of which include the following raw materials: Beiqi 30g, Xianlingpi 10g, Radix Paeoniae Rubra 10g, Curcuma zedoary 10g, Smilax tuckahoe 30g, and Stir-fried Atractylodes macrocephala 10g.

[0044] The above-mentioned components are taken, and the traditional Chinese medicine oral liquid is prepared according to the existing preparation method of the traditional Chinese medicine oral liquid. The proportion is one dosage, and the dosage of one dosage is about 300mL.

[0045] The preparation method of the traditional Chinese medicine oral liquid is as follows: mix Beiqi, Xianlingpi, Chishao, Curcuma, Smilax, and Stir-fried Atractylodes in parts by weight to obtain a mixture, and then add it into water according to the ratio of material to liquid at 1:15 and soak for 20 minutes. Decoct for 1 hour, filter to obtain the first filtrate, decoct the filter residue once, combine the ob...

Embodiment 3

[0047] A traditional Chinese medicine composition for treating colon cancer. The main active ingredients include the following raw materials: Beiqi 20g, Xianlingpi 10g, Radix Paeoniae Rubra 10g, Curcuma zedoary 5g, Smilax 30g, and Stir-fried Atractylodes macrocephala 15g.

[0048] The above-mentioned components are added to the carrier or excipient, and the granule drug is prepared according to the existing preparation method of traditional Chinese medicine granule.

[0049] Granule medicine can be prepared by following existing methods:

[0050] Obtain the filtrate according to the method for preparing decoction in Example 1, concentrate the filtrate under reduced pressure to obtain a clear paste, add maltodextrin to the clear paste, and then spray dry to obtain a dry paste powder; then add maltodextrin to the dry paste powder Refining to obtain a mixed powder; then adding a soft material made of ethanol-water solution with a volume fraction of 90% to the mixed powder, sievin...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating colon cancer. The main active ingredients include the following raw materials in parts by weight: 2-4 parts of Beiqi, 0.5-1 part of Xianlingspleen, and 1-1 part of Radix Paeoniae Rubra 1.5 parts, 0.5-1 part of Curcuma, 1.5-3 parts of Smilax, 0.5-1.5 parts of fried Atractylodes. The invention also provides the preparation method and application of the above-mentioned traditional Chinese medicine composition for treating colon cancer. Experiments on colon cancer-bearing mice showed that when the traditional Chinese medicine composition for treating colon cancer of the present invention was used in combination with chemotherapy drugs, although the tumor-inhibiting effect of chemotherapy drugs was not significantly enhanced, the survival time of mice could be significantly prolonged. Relieve the weight loss caused by chemotherapy drugs, increase the level of T lymphocytes in mice, especially significantly increase the CD4 + T lymphocytes, CD8 + The level of T lymphocytes shows that the traditional Chinese medicine composition for treating colon cancer of the present invention can improve the body immunity of colon cancer patients, thereby improving the quality of life and prolonging the survival time of patients.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating colon cancer, a preparation method and application thereof. Background technique [0002] Colon cancer has become the most common malignant tumor of the digestive system. The most common clinical features are abdominal pain, diarrhea, mucus pus and blood in the stool, stool deformation, diarrhea and constipation alternately, bloody or pus and blood in the stool, etc. Clinically, surgery and chemotherapy are the main means of treating colon cancer at present. However, after chemotherapy, the immune system of the human body is often disturbed and the quality of life of the patient is reduced. [0003] In the prior art, the patent with the publication number CN110575485A discloses a traditional Chinese medicine composition for treating colon cancer and a preparation method thereof. Grass, gecko, betel nu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P1/00A61P35/00A61P37/04
CPCA61K36/284A61K36/296A61K36/481A61K36/65A61K36/71A61K36/896A61K36/90A61K36/9066A61K2236/331A61P1/00A61P35/00A61P37/04A61K2300/00
Inventor 张海波肖真真朱燕娟刘译鸿常雪松陈亚栋余娅娅卢传坚
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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