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Application of bougainvillea glabra extract

A technology for leaf frondosa and extract, applied in the field of medicine and health care products or food, can solve the problems of unfavorable product quality and curative effect stability, incomplete development, lengthy preparation procedures, etc.

Inactive Publication Date: 2020-10-27
ANHUI DEXIN HUAHAI BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] The purpose of the present invention is to provide the application of the extract of Bougainvillea glabra, which solves the problem that the existing application and development of Bougainvillea glabra is not comprehensive, the existing preparation procedure is lengthy, it is not conducive to the stability of product quality and curative effect, and there is no deep-level influence on the efficacy of the drug. The problem of scientific interpretation

Method used

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  • Application of bougainvillea glabra extract
  • Application of bougainvillea glabra extract
  • Application of bougainvillea glabra extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The preparation method of the glabra bougainvillea extract of the present invention

[0054] 1. Extraction of branches and leaves of Bougainvillea glabra

[0055] 1. Preparation of water-extracted freeze-dried product:

[0056] Picking and selection of original leaves: select leaf buds or young leaves with light green color, no disease spots, and no pests, wash them, remove dust and microorganisms on the leaf surface, drain the water, and spread them evenly in a ventilated and dry place;

[0057] Withering: naturally wither for 3 hours, and turn it up and down once in the middle, until the leaves are soft and the water loss rate is 8%.

[0058] Boiling: Boil the withered glabra leaves and pure water for 2 hours according to the material ratio of 1:20, collect the extract, and boil again for 2 hours at the material ratio of 1:15, and collect the extract; Filtration: use the collected extract with 12 layers Filter through sterile gauze and collect the filtrate;

[0059...

Embodiment 2

[0083] Research on anti-alcoholic and hepatoprotective effect of the extract of glabra glabrata of the present invention

[0084] 1. Materials

[0085] 1. Experimental animals

[0086] SPF male Kunming mice, weighing 18-20 g, were provided by the Comparative Medicine Center of Yangzhou University, certificate number: SCXK (Su) 2017-0007.

[0087] 2. Drugs and reagents

[0088] Freeze-dried product of water-extracted branches and leaves of glabra: (see Example 1 for detailed preparation). During the experiment, a solution of corresponding concentration was prepared with physiological saline for intragastric administration of mice. The dosage for mice is 750 mg crude drug amount / kg, which is equivalent to 5.71 g crude drug amount / day for a 70 kg adult in terms of body surface area.

[0089] Water-extracted extract of glabra leaves: (see Example 1 for detailed preparation). During the experiment, a solution of corresponding concentration was prepared with physiological salin...

Embodiment 3

[0128] Research on the hypoglycemic and lipid-lowering activity of the extract of the present invention

[0129] 1. Test method:

[0130] animal husbandry

[0131] Take 8 male C57BL / 6 mice as the normal control group, take a number of dbdb male mice aged 7-8 weeks and feed them adaptively for one week, fast for 12 hours, cut off the tail to take blood, measure fasting blood sugar with a blood glucose meter, and select fasting blood sugar ≥ 11.1 The dbdb mice of mmol / L are type II diabetic mice.

[0132] 2. Administration of animals in groups

[0133] Modeled dbdb mice are divided into 10 groups: model control group, positive control group (pioglitazone hydrochloride sheet, Jiangsu Deyuan Pharmaceutical Co., Ltd.), water-extracted freeze-dried group (150mg / kg) of glabra leaves of the present invention, The present invention's bright leaf flower branch and leaf water extraction extract group (150mg / kg), the present invention's light leaf flower branch and leaf normal temperat...

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Abstract

The invention discloses an application of a bougainvillea glabra extract, and belongs to the technical field of medicines. The bougainvillea glabra extract is extracted from flowers and / or bracts and / or branches and / or leaves of the bougainvillea glabra, fresh branches and leaves of the bougainvillea glabra are mainly developed, the cost is low, and the bougainvillea glabra extract has notable social value and application value. The bougainvillea glabra extract can improve the activity of acetaldehyde dehydrogenase, can restrain abnormal rise of alanine aminotransferase and aspartate aminotransferase caused by alcohol, and has the efficacy of neutralizing the effect of alcoholic drinks and nourishing the liver; and besides, the bougainvillea glabra extract has the effects of reducing bloodsugar of mice suffering from type II diabetes, reducing blood lipid, improving tolerance of orally-taken glucose, and obviously reducing insulin resistance, and the like. The bougainvillea glabra extract can be used for preparing health-care foods for reducing blood sugar, reducing blood lipid and relieving insulin resistance, and has health-care effects of reducing blood sugar and blood lipid for crowds suffering from high blood sugar, high blood lipid, insulin resistance and the like of patients suffering from type II diabetes. The health-care foods are small in toxic and side effects and stable in quality.

Description

technical field [0001] The invention belongs to the field of medicine and health care products or food, and specifically relates to a method that can improve the activity of acetaldehyde dehydrogenase, inhibit the abnormal increase of alanine aminotransferase and aspartate aminotransferase caused by alcohol, and has the functions of lowering blood sugar, blood fat, improving glucose tolerance, and reducing insulin. The anti-resistance effect can be used to prepare anti-alcoholic and liver-protecting health food, blood sugar-lowering type, blood-fat-lowering type, and insulin resistance-lowering type health food. Background technique [0002] China is a big country in the production and consumption of alcoholic beverages. The annual consumption of alcoholic beverages has reached more than 10,000 tons. There are about 100 million people who are addicted to alcohol or alcohol dependent, and the rate of acute and chronic alcoholism is increasing day by day. [0003] Alcoholism i...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/16A61P3/10A61P3/06A23L33/105A61K133/00A61K127/00A61K135/00
CPCA23V2002/00A61K36/185A23L33/105A61P1/16A61P3/06A61P3/10A23V2200/32A23V2200/328A23V2200/3262
Inventor 康梦实戚微岩于瑞河
Owner ANHUI DEXIN HUAHAI BIOLOGICAL TECH CO LTD
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