Clean and environment-friendly production process of 2-chloro-5-chloromethylthiazole

Abstract

The invention relates to a clean and environment-friendly production process of 2-chloro-5-chloromethylthiazole, which comprises the following steps: dissolving sodium thiocyanate in water, dropwiselyadding 2, 3-dichloropropene, carrying out heat preservation reaction after the dropwisely adding is completed, washing the obtained material with water, layering, and distilling to obtain an intermediate product 2-chloropropenyl isothiocyanate; dissolving the intermediate product in dichloroethane, dropwise adding sulfonyl chloride for the first time at the temperature of 30-60 DEG C, carrying out heat preservation reaction after dropwise adding is finished, degassing, desolventizing and cooling the obtained material, dropwise adding sulfonyl chloride for the second time, carrying out heat preservation reaction after dropwise adding for the second time, adding a stabilizer into the obtained material, and distilling to obtain 2-chloro-5-chloromethylthiazole. According to the invention, a pure byproduct sodium chloride is obtained, and the problem of high ammonia-nitrogen wastewater is solved. Due to the fact that the sulfonyl chloride is appropriate in use amount and is added in two times, by-products of sulfur dioxide and hydrogen chloride gas are reduced, the problem of environmental pollution is solved, and the production process is mild in reaction condition, small in toxicity,high in yield and purity and environmentally friendly.

Description

technical field [0001] The invention relates to a production process of 2-chloro-5-chloromethylthiazole, in particular to a clean and environment-friendly production process of 2-chloro-5-chloromethylthiazole. Background technique [0002] The English name of 2-chloro-5-chloromethylthiazole is: 2-Chloro-5-Chloromethylthiazole, CAS registration number: 105827-91-6, molecular formula is: C 4 h 3 Cl 2 NS, molecular weight: 168.0443, structural formula is as follows: [0003] [0004] 2-Chloro-5-chloromethylthiazole is a key intermediate for the synthesis of highly effective insecticides thiamethoxam and clothianidin. Thiamethoxam and Clothianidin are a new generation of chlorinated nicotinic insecticides. They are strong systemic insecticides and are the receptors of nicotinic acid acetylcholinesterase. They are used to control sucking mouthparts pests , such as aphids, leaf-chan, planthoppers, thrips, whitefly and their resistant strains. At the same time, the toxicity ...

AI Technical Summary

Problems solved by technology

The main problem of route (4) is to neutralize the hydrogen chloride in 2-chloro-5-chloromethylthiazole hydrochloride, which needs to consume a large amount of alkali and produce a large amount of saline waste water, which increases a lot for the subsequent waste water treatment. large processing costs

[0008] The above technologies have not provided specific guidance on how to make the production process of 2-chloro-5-chloromethylthiazole mild in reaction conditions, low in toxicity, high in yield and purity, and environmentally friendly.

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