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Plant-based soft capsule shell as well as preparation method and application thereof

A technology of soft capsules and rubber skins, applied in capsule delivery, medical preparations of non-active ingredients, pharmaceutical formulas, etc., to achieve improved solubility, excellent tensile strength, and favorable release effects

Active Publication Date: 2020-09-25
JIANGSU FOOD & PHARMA SCI COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is still relatively little research on the rubber of plant-based soft capsules. Although there have been some patent reports, the formula still needs to be improved and perfected

Method used

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  • Plant-based soft capsule shell as well as preparation method and application thereof
  • Plant-based soft capsule shell as well as preparation method and application thereof
  • Plant-based soft capsule shell as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: A plant-based softgel rubber:

[0076] The present embodiment provides a kind of plant-based soft capsule rubber, and its specific components and contents thereof include:

[0077]

[0078]

[0079] The degree of substitution of the hydroxypropyl starch is 0.4, and

[0080] The grafting ratio of lactic acid to hydroxypropyl starch is 21%.

[0081] The soft capsule rubber described in this embodiment is specifically prepared through a method comprising the following steps:

[0082] 1) Preparation of hydroxypropyl starch / lactic acid graft copolymer:

[0083] 1.1) Add 10g of hydroxypropyl cornstarch to 75g of 0.25mol / L sodium carbonate solution, heat up to 68°C at 4°C / min for gelatinization for 45min, then add 40g of lactic acid, reduce the system pressure to 0.1MPa, then raise the temperature to 80°C, and react 1h;

[0084]1.2) Step 1.1) Add acetone after the system is lowered to room temperature, settle, filter with suction and dry at 50°C to obtain ...

Embodiment 2

[0096] Example 2: Another Plant-Based Softgel Gum:

[0097] This embodiment provides another plant-based soft capsule rubber. The components, formulations, and preparation methods of the soft capsule rubber are basically the same as those in Example 1. The only difference is that in the components of this embodiment, fiber Instead of cellulose / polylactic acid graft copolymer, cellulose is used to prepare soft capsule rubber without polylactic acid graft modification.

Embodiment 3

[0098] Example 3: Another Plant-Based Softgel Gum:

[0099] This embodiment provides another plant-based soft capsule rubber, the composition, formula and preparation method of the soft capsule rubber are basically the same as those in Example 1, the only difference is that no fiber is added to the components of this embodiment Vegetable / polylactic acid graft copolymer.

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Abstract

The invention relates to the technical field of soft capsule shell materials, in particular to a plant-based soft capsule shell and a preparation method and application thereof. The plant-based soft capsule shell comprises a hydroxypropyl starch / lactic acid graft copolymer, a cellulose / polylactic acid graft copolymer, a plasticizer, gel, edible pigment and water, wherein the substitution degree ofthe hydroxypropyl starch is not higher than 0.58, and the grafting rate of lactic acid to the hydroxypropyl starch is 14-25%. The main material of the soft capsule shell is derived from plants, and has extremely excellent disintegration time limit, and is beneficial to rapid release of the capsule in an organism. The soft capsule shell has excellent performance in the aspects of friability, disintegration time, tensile strength, elongation at break and the like, and meanwhile, and has excellent ageing resistance and remarkably-prolonged storage life.

Description

technical field [0001] The invention relates to the technical field of soft capsule rubber materials, in particular to a plant-based soft capsule rubber, a preparation method and an application thereof. Background technique [0002] Soft capsule refers to the liquid or molten drug mixture containing certain active ingredients, or the solution, suspension, emulsion or semi-solid (paste, etc.) mixture containing solid drug dispersion, sealed in a spherical or oval shape. Capsules with soft capsules. The advantage of soft capsules is that the embedded content is completely isolated from external factors such as air, so as to prevent the active ingredients in the content from being destroyed by external factors; therefore, 1) oily drugs, low melting point drugs; 2) light-sensitive , Drugs that are unstable or easily oxidized when exposed to heat and humidity; 3) Drugs with bad odor and trace active drugs; 4) Drugs with volatile components that are easy to escape; 5) Hydrophobic...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36A61K47/34
CPCA61K9/4808A61K9/4816A61K47/34A61K47/36
Inventor 不公告发明人
Owner JIANGSU FOOD & PHARMA SCI COLLEGE
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