Method for detecting glucose based on cobalt-based metal organic framework enzyme-free glucose sensor
A glucose sensor and organic framework technology, applied in the field of glucose detection, can solve problems such as poor conductivity, and achieve the effects of simple equipment, fast and accurate detection, and fast detection speed.
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Embodiment 1
[0048] A method for detecting glucose based on a cobalt-based metal organic framework enzyme-free glucose sensor, comprising the steps of:
[0049] (1) Preparation of ionic liquid [BMI]Br
[0050] Mix 0.138 mol of N-methylimidazole purified by distillation and 0.212 mol of degassed butyl bromide in a three-necked flask, reflux at 50°C, and react for 5 hours to obtain a light yellow oily ionic liquid [BMI]Br;
[0051] (2) Preparation of cobalt-based metal organic framework material Co-MOF
[0052] Take 1.00mmolCo(NO 3 ) 2 ·6H 2 O, 0.50 mmol H 2 BDC and 1mL [BMI]Br were mixed, placed in a 25mL reactor, and reacted at 140°C for 7 days to obtain Co-MOF, a cobalt-based metal-organic framework material;
[0053] (3) Preparation of modified electrodes
[0054] Polish the glassy carbon electrode on the suede with 1μm, 0.3μm and 50nm alumina in sequence, and then ultrasonically clean it with dilute nitric acid, absolute ethanol and deionized water to obtain a mirror-bright glassy...
Embodiment 2
[0066] A method for detecting glucose based on a cobalt-based metal organic framework enzyme-free glucose sensor, comprising the steps of:
[0067] The preparation of ionic liquid [BMI] Br, the preparation of Co-MOF carry out by embodiment 1,
[0068] (1) The ground Co-MOF (195 mg) was placed in 10 mL of 2M NaOH solution, stirred at room temperature for 1 h, then centrifuged at 8000 rpm, and finally dried at 70 °C for 12 h.
[0069] (2) Co(OH) obtained in step (1) 2 Put the powder in an agate mortar for grinding, then take 1.5mg in 1mL of absolute ethanol, and ultrasonicate for 20min to form a well-dispersed dispersion; take 10μL drop-coated on the polished glassy carbon electrode, and then drop 5μL Nafion (1% ) to fix.
[0070] (3) Test the current response value of the cobalt-based metal-organic framework enzyme-free glucose sensor to a known concentration of glucose solution at an applied potential of 0.6V. The concentration of the glucose solution is 5 μM to 900 μM, and ...
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