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Preparation method of surface coating of orthopedic implantation instrument

A surface coating and device technology, which is applied in the field of surface modification of orthopedic implant devices, can solve the problems of limited pH-responsive controlled release performance, difficult antibacterial and osteogenic functions, and large gaps in required concentrations to achieve good osteogenesis effects , The preparation method is simple and convenient, and the effect of good antibacterial effect

Active Publication Date: 2020-08-14
PEKING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Considering that the pH-responsive controlled release performance of the polydopamine film layer is limited, and the required concentration gap between copper ion antibacterial and osteogenesis is large, it is difficult for the polydopamine film layer to make the material meet the antibacterial and osteogenic functions at the same time.

Method used

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  • Preparation method of surface coating of orthopedic implantation instrument
  • Preparation method of surface coating of orthopedic implantation instrument
  • Preparation method of surface coating of orthopedic implantation instrument

Examples

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Embodiment 1

[0031] The process of preparing polydopamine coating containing copper-citrate composite nanoclusters on the surface of polyether ether ketone is as follows: figure 1 As shown, the specific steps are as follows:

[0032] (1) Substrate material pretreatment: select medical grade PEEK rods, and use mechanical processing technology to cut them into Φ15x1.5mm 3 The discs were polished step by step with 400#, 800#, 1200#, 1500# and 2000# metallographic sandpaper, and then ultrasonically cleaned in acetone, ethanol and deionized water for 20 minutes, and the surface moisture was dried with filter paper. Air-dried and stored in a vacuum oven;

[0033] (2) Polyether ether ketone sulfonation treatment: PEEK sample was added into concentrated sulfuric acid, and stirred ultrasonically for 5 minutes. The samples were then taken out and ultrasonically cleaned in deionized water for 20 minutes. After cleaning, put the sample into a beaker with deionized water, heat it on a resistance fur...

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Abstract

The invention relates to the technical field of surface coating modification of orthopedic implantation instruments, in particular to a preparation method of a surface coating of an orthopedic implantation instrument, and provides a method for loading and controlling release of copper-citrate nanoclusters on the surface of the orthopedic implantation instrument through polydopamine. The preparation method of the coating is simple and convenient, is wide in application range, and can be applied to various orthopedic implantation instruments. Besides, the change of the ph value can be respondedthrough polydopamine, and the release concentration of the copper ions can be regulated and controlled, so that the conversion between osteogenesis and antibacterial functions of the implanted instrument is controlled.

Description

technical field [0001] The invention relates to a method for modifying the surface of an orthopedic implant device, which belongs to the field of surface modification of medical devices and sustained drug release. Background technique [0002] Orthopedic implants often fail after they are implanted into the human body, and insufficient osseointegration of implanted devices and bacterial infection are the main reasons for implant failure. In order to further improve the success rate of implantation and reduce the harm of implantation failure to human life and health, it is necessary to endow implanted devices with excellent osteogenic and antibacterial properties. But in most cases, many methods that can endow implanted devices with osteoinductive properties do not consider the risk of bacterial infection, and even methods that promote cell adhesion and proliferation are beneficial to both bacterial adhesion and biofilm formation. Conversely, strategies aimed at inhibiting b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/50A61L27/54A61L27/56B22F1/00B22F9/24B82Y30/00B82Y40/00
CPCA61L27/34A61L27/56A61L27/54A61L27/50B22F9/24B82Y30/00B82Y40/00A61L2400/18A61L2300/404A61L2300/412A61L2300/606A61L2420/06B22F1/054C08L79/04
Inventor 鄢江龙夏丹丹郑玉峰成艳
Owner PEKING UNIV
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