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A kind of honeysuckle vacuum freeze-drying process

A vacuum freeze-drying and vacuum-drying technology, applied in the direction of drying solid materials, drying solid materials without heating, drying, etc., can solve the problems of water loss of plant tissue cells, no subsequent discharge, large production investment, etc., to avoid The effect of excessive sulfur dioxide content, high utilization rate and high dissolution rate

Active Publication Date: 2022-02-15
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Theoretically, the vacuum freeze-drying method has a protective effect on the easily oxidized and decomposed components in the medicinal material, and is most suitable for the initial processing of the medicinal material. However, the current domestic research results have not reflected the content analysis of the active ingredients and nutritional components of the freeze-dried samples of honeysuckle. On the one hand, the advantages of freeze-drying are due to the rapid loss of local water in plant tissue cells during the freeze-drying process, forming cell cavities, and the air in the cavities is not discharged. The enzyme is not able to continue to oxidize the active ingredients in it, resulting in the decomposition of the active ingredients in the plant tissue. The most important reason is related to the specific process requirements of freeze-drying. At present, no one has systematically carried out the research on the vacuum freeze-drying process of honeysuckle.
In addition, the price of the vacuum freeze dryer itself is high, the production investment is large, the drying time is long, and the energy consumption is large, which has caused many researchers to give up the research on the vacuum freeze-drying of honeysuckle.

Method used

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  • A kind of honeysuckle vacuum freeze-drying process
  • A kind of honeysuckle vacuum freeze-drying process
  • A kind of honeysuckle vacuum freeze-drying process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A honeysuckle vacuum freeze-drying process, comprising the following steps:

[0029] (1) Pretreatment

[0030] (2) Arrangement, the placement thickness of honeysuckle is 1-3mm;

[0031] (3) Pre-freeze, put the honeysuckle into a vacuum freeze dryer, reduce the temperature of the honeysuckle to -30°C to -35°C, and keep it for 4-5 hours;

[0032] (4) Vacuum drying, when the temperature in the cold trap is lowered to -60°C, the vacuum degree is maintained at 20-30Pa, and the vacuum is started for sublimation drying, and the temperature is raised to 35-45°C in the drying chamber, and the vacuum degree reaches 1-10Pa After the end, the vacuum freeze-dried honeysuckle was obtained.

[0033]The specific steps of sublimation drying are as follows: the temperature of honeysuckle is maintained at -30°C to -35°C, and kept for 3.5 hours; the temperature of honeysuckle is recovered and maintained at -30 to -20°C, and kept for 2 hours; ~-10℃, keep for 2 hours; honeysuckle temperat...

Embodiment 2

[0036] Example 2 Analysis of Honeysuckle Characters by Different Drying Methods

[0037] The flowers were processed according to the conditions in Table 1, and each sample was repeated 3 times in parallel.

[0038] Table 1 Different honeysuckle drying methods

[0039]

[0040] Analysis of traits of honeysuckle by different drying methods

[0041] Table 2 Appearance traits of different dried honeysuckle

[0042]

[0043]

Embodiment 3

[0044] Method and Analysis of Organic Acid Content in Flos Lonicerae by Different Drying Methods in Example 3

[0045] (1) Chromatographic conditions

[0046] The content of the active ingredient was determined by HPLC, and the determination conditions were as follows: Chromatographic column: Agilent ZORBAX XDB-C18 (4.6mm×250mm, 5 μm); mobile phase A: 0.1% formic acid water, mobile phase B: acetonitrile; column temperature: 30°C; Injection volume: 20 μl; detection wavelength: 240nm, 325nm, 350nm; see Table 3 for mobile phase elution gradient. The number of theoretical plates calculated based on chlorogenic acid shall not be less than 5000.

[0047] Table 3 Gradient elution table of HPLC mobile phase

[0048]

[0049] (2) Preparation of reference substance solution

[0050] Accurately weigh 9.79mg of neochlorogenic acid, 10.75mg of cryptochlorogenic acid, 11.09mg of caffeic acid, 9.29mg of isochlorogenic acid B, and 4.32mg of deoxidized loganin, place them in 1ml volumetr...

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Abstract

The invention relates to the technical field of honeysuckle processing, in particular to a vacuum freeze-drying process for honeysuckle, which includes the steps of pretreatment, arranging, pre-freezing and vacuum drying. The invention utilizes the method of rapid freezing in advance to reduce the vacuum freeze-drying time, reduce energy consumption, and avoid continuous oxidation and decomposition of substances under the action of enzymes in the drying process. This invention studies the process of vacuum freeze drying and processing honeysuckle for the first time, and optimizes its process parameters, so that the heat of the supplied material is the least, the sublimated water is the fastest, the time required for drying is the shortest, and the energy consumed per unit mass of water is the lowest. , the product quality after drying is the best. Organic acids, flavonoids, volatile oils, saponins and other components in the honeysuckle obtained by the present invention are higher than those obtained by other methods, and the content of chlorogenic acid is 3.19%. has clear advantages.

Description

technical field [0001] The invention relates to the technical field of honeysuckle processing, in particular to a honeysuckle vacuum freeze-drying process. Background technique [0002] Drying can ensure that materials will not be corrupted and deteriorated, and is the most common technology in current social production. Vacuum freeze-drying refers to the method of pre-freezing the water-containing substance into a solid state, and then sublimating the water in it from a solid state to a gaseous state under a vacuum state to remove moisture and preserve the substance. This technology has incomparable advantages under conventional drying. The solid matter after freeze-drying has a porous structure and maintains the volume when it is frozen. It can be easily dissolved and restored by adding water, and can remove 95% to 99% of water. In recent years, the development of vacuum freeze-drying technology has been very rapid, especially in China, especially in the fields of food pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/355F26B5/06
CPCA61K36/355F26B5/06A61K2236/10A61K2236/17
Inventor 刘谦张喆邓志鹏蒲高斌王玲娜李佳张永清
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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