Pre-radiation grafting synthesis method of nano oxide-based blood rapid coagulant

A technology of nano-oxide and synthesis method, which is applied in the field of pre-radiation grafting synthesis of nano-oxide-based blood rapid coagulant, can solve the problems of high cost, interference of test results, inaccurate test results, etc. Avoid secondary pollution, fast and accurate test results

Active Publication Date: 2020-07-28
HUBEI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional blood coagulants are kaolin, cephalin and thrombin, but the first two components will interfere with the test results, resulting in inaccurate test results, and thrombin needs to be equipped with special equipment, which costs a lot of major defects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh a certain amount of nano-SiO 2 Put the powder into a vacuum PE sealed bag (thickness about 2mm), place it under the electron beam for irradiation, the selected electron beam energy is 1MeV, the radiation dose is 10kGy, and the dose rate is 5kGy / pass. 2 Samples were quickly put into a three-necked flask containing glycidyl methacrylate (5%), Tween 80 (0.5%), and sodium dihydrogen phosphate (0.1%) solutions, and N 2 and stirred for 0.5h, the obtained sample was taken, washed with acetone and water, and dried in a vacuum oven at 60°C for 24h to obtain nano-SiO 2 Blood-based rapid coagulant.

[0027] Take a sterilized glass test tube with an inner diameter of 8 mm and add 100 μL (1 g / mL) of SiO 2 Blood-based rapid coagulant suspension, using test tube method for blood experiments. Add 0.5mL rat blood to the above test tube, quickly put the test tube into a constant temperature water bath at 37±0.5°C, mix gently, and time immediately. Gently tilt the test tube every...

Embodiment 2

[0029] Weigh a certain amount of nano-TiO 2 Put the powder into a vacuum PE sealed bag (thickness about 2mm), place it under the electron beam for irradiation, the selected electron beam energy is 1MeV, the radiation dose is 30kGy, and the dose rate is 10kGy / pass. 2 Samples were quickly put into a three-necked flask containing N-isopropylacrylamide (10%), polyethylene glycol 2000 (1%), and triethanolamine (0.2%) solutions, and N 2 and stirred for 1 h, the obtained sample was taken, washed with alcohol and water, and dried in a vacuum oven at 60°C for 24 h to obtain nano-TiO 2 Blood-based rapid coagulant.

[0030] Take a sterilized glass test tube with an inner diameter of 8 mm and add 100 μL (1 g / mL) of TiO 2 Blood-based rapid coagulant suspension, using test tube method for blood experiments. Add 0.5mL rat blood to the above test tube, quickly put the test tube into a constant temperature water bath at 37±0.5°C, mix gently, and time immediately. Gently tilt the test tube e...

Embodiment 3

[0032] Weigh a certain amount of nano-CaO powder into a vacuum PE sealed bag (thickness about 2mm), place it under the electron beam for irradiation, the selected electron beam energy is 1MeV, the radiation dose is 60kGy, and the dose rate is 30kGy / pass. The irradiated nano-CaO sample was quickly put into a three-necked flask containing a solution of hydroxyethyl methacrylate (20%), Span 60 (2%), and acetic acid (1%). 2 And stirred for 2 hours, the obtained sample was taken, washed with alcohol and water, and dried in a vacuum oven at 60°C for 24 hours to prepare a nano-CaO-based blood coagulation accelerator.

[0033]Take a sterilized glass test tube with an inner diameter of 8 mm, add 100 μL (1 g / mL) of CaO-based rapid blood coagulant suspension, and use the test tube method for blood experiments. Add 0.5mL rat blood to the above test tube, quickly put the test tube into a constant temperature water bath at 37±0.5°C, mix gently, and time immediately. Gently tilt the test tub...

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Abstract

The invention provides a pre-radiation grafting synthesis method of a nano oxide-based blood rapid coagulant, and belongs to the technical field of medical auxiliary materials. The synthesis method includes: placing the nano oxide powder under an electron beam for pre-irradiation; rapidly putting the obtained sample into a three-neck flask containing a double-bond unsaturated monomer solution (5%-30%), a surfactant (0.5%-5%) and a pH regulator (0.1%-2.0%); feeding N2 and stirring the mixture for 0.5-2 hours, carrying out alcohol washing and water washing on a sample, and drying the product ina vacuum drying oven at 60 DEG C for 24 hours, thereby preparing the nano oxide-based blood rapid coagulant at the temperature of 40-100 DEG C. A monomer containing a hydrophilic functional group or ahydrophobic functional group is introduced into the surface of the nano oxide, so that the nano oxide is ensured to have good dispersity, hydrophilicity or hydrophobicity; the synergistic effect of rapid blood coagulation can be realized, and the high-quality separation effect of serum can also be realized.

Description

technical field [0001] The invention belongs to the technical field of medical auxiliary materials, and relates to a pre-radiation graft synthesis method of a nano-oxide-based blood rapid coagulation accelerator. Background technique [0002] Nanomaterials have quantum size effect, small size effect, dielectric effect, macroscopic quantum tunnel effect and surface effect. Especially when the particle size of nanomaterials is less than 10nm, it can bring unpredictable effects. The excellent characteristics of nano-oxides in terms of microstructure, photoelectricity and chemical properties have brought new opportunities to the development of physics, chemistry, materials, biology, medicine and other disciplines. [0003] The coagulation system includes the intrinsic coagulation system and the extrinsic coagulation system, and the latter plays a major role in initiating the coagulation process. The activation of the extrinsic coagulation system begins with the release of tiss...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F292/00C08F220/32C08F220/54C08F220/20C08F226/10
CPCC08F292/00C08F220/54C08F220/20C08F226/10
Inventor 李月生李婷婷柳国宋晓芳杨金玉汪政熙张方方
Owner HUBEI UNIV OF SCI & TECH
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