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Dentifrice comprising zinc - amino acid complex

A technology of complexes and amino acids, used in medical preparations containing active ingredients, dentistry, oral care, etc.

Pending Publication Date: 2020-07-17
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This problem is solved by replacing the anionic polymer with a nonionic polymer such as hydroxyethyl cellulose

Method used

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  • Dentifrice comprising zinc - amino acid complex
  • Dentifrice comprising zinc - amino acid complex

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0150] The preparation of embodiment 1-ZLC

[0151] The general reaction that forms ZLC in the present embodiment is as follows:

[0152] ZnO+2(lysine·HCl)-? [Zn(Lysine) 2 Cl]Cl H 2 O(ZLC)

[0153] A 2:1 molar ratio ZnO:Lysine·HCl suspension was prepared with stirring at room temperature for about 12 hours. The mixture was centrifuged. Transfer 1 ml of the suspension to an NMR tube. The NMR tube was then placed in a closed tube filled with ethanol for crystal growth. After one week many colorless cubic crystals formed. The crystal structure of ZLC crystals was determined by single crystal X-ray diffraction. The dimensions of this complex molecule are 1.7nm*7.8nm*4.3nm. In this complex, the Zn cation is coordinated by two lysine ligands, from which the NH 2 The two N atoms of the group and the O atom from the carboxyl group are on the equatorial plane. It displays a distorted square-pyramidal geometry with apex positions occupied by Cl atoms. This novel structure ge...

Embodiment 2

[0155] Example 2 - Dentifrice with ZLC

[0156] Dentifrice compositions with ZLC were prepared, the formulations of which are shown in Table 1.

[0157] Table 1

[0158] Composition (weight%) Formulation A Formulation B Formulation C sodium fluoride 0.32 0.32 0.32 Zinc oxide 1.05 1.05 1.05 HCL 37% 0.68 0.68 0.68 Lysine hydrochloride 4.72 4.72 4.72 85% phosphoric acid 0.2 0.2 0 Sodium Hydroxide 50% 0 0 0.5 sodium saccharin 0.8 0.2 0.2 Sucralose 0 0.02 0.02 Titanium dioxide 0.4 0.4 1 CMC sodium type 12 0.2 0.5 0 xanthan gum 0.4 0 0 Plasdone K90 (PVP) 0 1 1 Hydroxyethyl cellulose 0 0 0.2 Surfactant 2.75 2.75 2.75 silica 21 19 26 glycerin 42.28 43.5 36.1 Polyethylene glycol 600 3 3 3 Propylene Glycol 4 4 4 STPP 2 2 2 flavoring agent 1.2 1.7 1.45 Deionized water 15 15 15 pH of the formulation 7.6...

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Abstract

Disclosed herein are dentifrices comprising a zinc - amino acid complex together with a thickening system comprising a non-ionic thickening agent, which have a pH greater than 8.0. Methods of using the dentifrices are also provided.

Description

Background technique [0001] Dental erosion involves demineralization and damage to the tooth structure due to acidic attack from non-bacterial sources. Erosion is initially found in the enamel and, if left unchecked, may progress to the underlying dentin. Acidic foods and drinks, exposure to chlorinated swimming pool water, and acid reflux may cause or exacerbate tooth erosion. Enamel is a negatively charged surface that naturally tends to attract positively charged ions such as hydrogen and calcium ions, while repelling negatively charged ions such as fluoride ions. Depending on the relative pH of the surrounding saliva, the enamel will lose or gain positively charged ions, such as calcium ions. Normally saliva has a pH between 7.2 and 7.4. When the pH decreases and the concentration of hydrogen ions becomes relatively high, the hydrogen ions replace the calcium ions in the enamel, forming hydrogen phosphate (phosphoric acid), which damages the enamel and creates a porous,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/27A61K8/44A61K8/73A61K8/81A61K8/86A61K8/19A61Q11/00
CPCA61K8/27A61K8/44A61K8/19A61Q11/00A61K2800/58A61K8/8176A61K8/86A61K8/731A61K8/58A61K8/21A61K8/24A61K8/463A61K8/25A61K8/442A61K2800/48
Inventor 格里戈里·谢夫奇克劳伦·埃文斯
Owner COLGATE PALMOLIVE CO
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