Medical hydrogel and preparation method thereof
A hydrogel and medical technology, applied in the field of medical hydrogel and its preparation, can solve the problems such as the inability to balance mechanical properties and biocompatibility, and achieve the effects of good clinical application prospects, excellent mechanical properties, and simple operation.
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[0019] The embodiment of the present invention provides a preparation method of medical hydrogel, comprising the following steps:
[0020] S01. providing an acidic aqueous solution of gelatin;
[0021] S02. Adding a coupling agent to the acidic aqueous solution of gelatin to carry out the first crosslinking reaction to obtain a gelatin / coupling agent solution, wherein the coupling agent is a silane coupling agent containing amino and / or epoxy bonds ;
[0022] S03. Put the gelatin / coupling agent solution at 1-4°C to obtain a gelatin / silica hybrid hydrogel;
[0023] S04. Soak the gelatin / silicon dioxide hybrid hydrogel in a specific salt solution, so that the gelatin in the gelatin / silicon dioxide hybrid hydrogel is spontaneously cross-linked, and after soaking for 1-2 days, in Drying at room temperature for 2-3 days to obtain gelatin / silicon dioxide toughened hydrogel, wherein the specific salt solution is formed by sulfate, monohydrogen phosphate, dithiosulfate anions and am...
Embodiment 1
[0050] A preparation method of medical hydrogel, comprising the following steps:
[0051] S11. Under the condition of 38-55°C, add gelatin powder into 0.01N HCl solution, carry out stirring reaction, and prepare an acidic aqueous solution of gelatin;
[0052] S12. At 50°C, in the acidic gelatin solution, add GPTMS dropwise, stir and react at 450 rpm for 6-14 hours, and perform the first cross-linking reaction to obtain a gelatin / coupling agent solution;
[0053] S13. Standing the gelatin / coupling agent solution at 1-4°C to obtain a gelatin / silica hybrid hydrogel;
[0054] S14. At room temperature, add a specific salt such as ammonium sulfate powder in ultrapure water, and carry out a stirring reaction to prepare a sulfate ion solution; soak the gelatin / silicon dioxide hybrid hydrogel in the sulfate ion solution, The gelatin in the gelatin / silicon dioxide hybrid hydrogel is spontaneously cross-linked, soaked for 1-2 days, and then dried at room temperature for 2-3 days to obta...
Embodiment 2
[0056] A preparation method of medical hydrogel, comprising the following steps:
[0057] S11. Under the condition of 38-55°C, add gelatin powder into 0.01N HCl solution, carry out stirring reaction, and prepare an acidic aqueous solution of gelatin;
[0058] S12. At 50°C, in the acidic gelatin solution, add GPTMS dropwise, stir and react at 450 rpm for 6-14 hours, and perform the first cross-linking reaction to obtain a gelatin / coupling agent solution;
[0059] S13. Put the gelatin / coupling agent solution at 1-4°C to obtain a gelatin / silica hybrid hydrogel; add the hydrolyzed orthosilicate solution to the gelatin / coupling agent In the solvent solution, stir and react for 15-60min at a rotation speed of 450rpm to obtain a hydrogel hybrid system;
[0060] S14. At room temperature, add a specific salt such as ammonium sulfate powder to ultrapure water, and carry out a stirring reaction to prepare a sulfate ion solution; soak the hydrogel hybrid system in the sulfate ion solutio...
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