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Application of lycium barbarum polysaccharide to preparation of medicament or health-care product for repairing damaged nerves

A technology of Lycium barbarum polysaccharide and damage repair, which is applied in the field of medicine to achieve the effects of relieving nerve damage, high safety and clear efficacy

Pending Publication Date: 2020-07-17
宁夏天仁枸杞生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lycium barbarum polysaccharides have many reports on regulating the body's immunity, scavenging oxygen free radicals, inhibiting tumors, delaying aging, lowering blood lipids, lowering blood sugar, and anti-fatigue, but there are few reports on the neuroprotection and nerve repair of the central nervous system.

Method used

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  • Application of lycium barbarum polysaccharide to preparation of medicament or health-care product for repairing damaged nerves
  • Application of lycium barbarum polysaccharide to preparation of medicament or health-care product for repairing damaged nerves
  • Application of lycium barbarum polysaccharide to preparation of medicament or health-care product for repairing damaged nerves

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Effect of Lycium barbarum polysaccharide (LBP) on Huntington transgenic mice

[0018] 1. Test sample

[0019] The preparation method of Lycium barbarum polysaccharide (LBP): (1) Degreasing and deoligosaccharides: Ningxia Lycium barbarum was dried at 60°C and refluxed with chloroform-methanol (2:1) to degrease. After three times, the residue was filtered out and air-dried. 80% ethanol to remove oligosaccharides, reflux twice. (2) Extraction of crude polysaccharides: extract the residue in the previous step (removed fat-soluble substances and oligosaccharides) with distilled water at about 90°C, and combine the filtrate after 3 times to concentrate; Precipitate the filtrate with 95% ethanol by volume at least twice and then perform suction filtration (or centrifugation), wash the solid in 95% ethanol, absolute ethanol, and acetone in sequence by volume fraction, and obtain crude Lycium barbarum polysaccharide after vacuum drying. (3) Treatment and column p...

Embodiment 2

[0063] Example 2: Effects of Lycium barbarum polysaccharide (LBP) on the body under heat exposure

[0064] 1. Experimental materials: 24 5-week-old male SD rats, body weight 150-180 g, provided by the Experimental Animal Center of Ningxia Medical University, feeding conditions: room temperature 18-25°C, 12h light cycle. Lycium barbarum polysaccharide LBP (Ningxia Wolfberry Biological Food Co., Ltd., content ≥ 30%, production batch number: 64WFBR100501), enzyme-linked immunosorbent assay kit (CUSABIO, Uscn company), RNA extraction kit (AXY-GEN, reverse transcription Reagent kit (Beijing Quanshijin Biotechnology Co., Ltd.), qPCRSuperMix (SYBR Green) (Beijing Quanshijin Biotechnology Co., Ltd.), artificial climate chamber (Hangzhou Qianjiang), enzyme-linked immunoassay instrument (BIO-RAD680, Bio-Rad, USA) ), PCR instrument (BIO-RAD), real-time fluorescence quantitative PCR instrument (ABI company).

[0065] 2. Animal grouping and model establishment: randomly divided into contr...

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Abstract

The invention relates to the field of medicines, and in particular to an application of lycium barbarum polysaccharide to preparation of a medicament or health-care product for repairing damaged nerves, and aims to provide the application of lycium barbarum polysaccharide to preparation of a medicament or health-care product for repairing damaged nerves, wherein the medicament or the health-care product has functions of improving neurodegenerative diseases, relieving nerve damage and repairing nerve damage. According to the application, the lycium barbarum polysaccharide is mixed with pharmaceutically acceptable auxiliary materials or auxiliary materials of health-care products to be made into tablets, powders, granules, pills, ointments, aquae, capsules or injections in various forms. Thebeneficial effect is as follow that the medicament or health-care product consisting of the lycium barbarbarbarbarum polysaccharide has the nerve protection effects of relieving nerve damage, repairing nerve damage, relieving neurodegenerative disorders and the like, has definite drug effect and high safety, and provides a new drug selection for clinic.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of Lycium barbarum polysaccharide in the preparation of drugs for repairing damaged nerves or health care products. Background technique [0002] The nervous system can be divided into: central nervous system and peripheral nervous system. The peripheral nervous system can be divided into: afferent nervous system and efferent nervous system. According to function, nerves can be divided into: (1) motor nerve (motor nerve), also known as efferent nerve (efferent nerve), is an efferent nerve, composed of motor nerve fibers (also called efferent nerve fibers); There are two types of somatic motor nerves and visceral motor nerves. The somatic motor nerves are efferent nerves innervating skeletal muscles, and most of them are composed of thick myelinated nerve fibers; the visceral motor nerves are vegetative nerves, which innervate smooth muscles The efferent nerves of , myoca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P25/28A61P25/00
CPCA61K31/715A61P25/28A61P25/00
Inventor 于哲雄
Owner 宁夏天仁枸杞生物科技股份有限公司
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