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Application of Necrostatin-1 in drugs for treating neurodegenerative eye disease

A technology for neurodegenerative and eye diseases, applied in the fields of biology and medicine, can solve the problem that Necrostatin-1 plays a positive role in neurodegenerative eye diseases that have not been reported, and achieve the effect of inhibiting retinal necrosis, increasing the amplitude of the waveform, and reducing the number

Inactive Publication Date: 2017-12-29
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

Current studies have not reported that Necrostatin-1 plays a positive role in the treatment of neurodegenerative eye diseases

Method used

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  • Application of Necrostatin-1 in drugs for treating neurodegenerative eye disease
  • Application of Necrostatin-1 in drugs for treating neurodegenerative eye disease
  • Application of Necrostatin-1 in drugs for treating neurodegenerative eye disease

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Experimental program
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Embodiment Construction

[0046] The technical scheme of the present invention will be further described in conjunction with experiments below.

[0047] 1. Pre-experiment preparation

[0048] 1.1 Experimental animals

[0049] Wild-type C57BL / 6 mice were purchased from the Experimental Animal Center of Guangdong University of Traditional Chinese Medicine. rd1 mice were purchased from Beijing Weitong Lihua Company. Animal ethics and all experimental operations complied with the "Regulations on the Administration of Experimental Animals" of the National Science and Technology Commission.

[0050] 1.2 Experimental reagents and antibodies

[0051] Necrostatin-1 (Sigma); H 2 o 2 (Sigma); anti-iba-1 antibody (Wako); anti-RIP1 antibody (BDbioscience); anti-RIP3 antibody (abcam); anti-MLKL antibody (abcam); anti-TNF-α antibody (abcam); anti-CCL2 antibody (Novus); Anti-IL-17 antibody (abcam); anti-caspase-3 antibody (BD bioscience); optimal cutting temperature compound (OCT) embedding fluid; anti-Actin ant...

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Abstract

The invention relates to an application of Necrostatin-1 in drugs for treating the neurodegenerative eye disease. The neurodegenerative eye disease with the typical retinal pigment degeneration of mice is treated through the Necrostatin-1, the Necrostatin-1 can notably inhibit programmed necrosis of retinal microglial cells, relieve local neuroinflammation of the retina and improve the inflammatory microenvironment, so that the cell apoptosis progress of a retina photoreceptor is delayed, loss of neuron is effectively inhibited, and the purpose of treating retinal degeneration is achieved. A new strategy is provided for treatment of the neurodegenerative eye disease, and the Necrostatin-1 has broad application prospects in preparation of pharmaceutical preparations for treating the neurodegenerative disease.

Description

technical field [0001] The invention relates to the technical fields of biology and medicine, in particular to the application of specific inhibitors in the treatment of eye diseases. Background technique [0002] Retinal neurodegenerative disease is a kind of refractory eye disease with photoreceptor or retinal pigment epithelial cell degeneration and death as the main pathological changes, mainly including retinitis pigmentosa, age-related macular degeneration, etc. It is a typical neurodegeneration, eventually It leads to irreversible loss of visual function and seriously affects human life. [0003] Neuroinflammation is an important pathological basis of retinal neurodegenerative diseases. In retinal neurodegenerative diseases such as retinitis pigmentosa and age-related macular degeneration, abnormally active retinal inflammatory responses are common: immune cell dysfunction triggers abnormal immune responses, releases a large amount of inflammatory factors, promotes n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4178A61P27/02A61P25/00
CPCA61K31/4178
Inventor 柳夏林何嫦黄梓敬
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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