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Black phosphorus composition, biological material containing black phosphorus composition, preparation method and application

A composition and mixture technology, applied in the field of biomedicine, can solve the problems that artificial nerve guides cannot achieve the effect of autologous nerve transplantation, and achieve the effects of easy quality control, wide application, and simple preparation

Active Publication Date: 2020-07-14
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the defects in the prior art and overcoming the problems existing in the existing stents, nerve guides or other guides, such as the fact that the current artificial nerve guides cannot achieve the effect of autologous nerve transplantation, etc., the present invention provides a black phosphorus composition, a stent, and a guide tube Preparation method and application

Method used

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  • Black phosphorus composition, biological material containing black phosphorus composition, preparation method and application
  • Black phosphorus composition, biological material containing black phosphorus composition, preparation method and application
  • Black phosphorus composition, biological material containing black phosphorus composition, preparation method and application

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preparation example Construction

[0054] The preparation method of the biocompatible material of described black phosphorus-containing composition, described method specifically comprises the following steps:

[0055] A, each component in the described black phosphorus composition is mixed in proportion to obtain mixture;

[0056] B. The mixture prepared in step A is subjected to 3D printing, coating method, mold method or electrospinning to obtain a catheter.

[0057] In the step A, the preparation of the mixture includes mixing the biocompatible material, black phosphorus and bioadhesive substance to prepare a suspension, or adding black phosphorus to the molten biocompatible material, bioadhesive Substances mixed in the system.

[0058] The preparation method also includes the following steps C:

[0059] C. Spray the inner wall, outer wall or inner and outer walls of the catheter with bioadhesive substances by 3D printing, coating method or electrospinning method as required, and carry out cross-linking a...

Embodiment 1

[0061] The preparation of embodiment 1 black phosphorus composition

[0062] Based on the total weight of 100%, the black phosphorus (single-layer black phosphorus or multi-layer black phosphorus) weight ratio is respectively 0.001%, 0.025%, 0.01%, 0.02%, 0.05% and 0.099% and biocompatible material ( PCL, PLA, PLGA, collagen, gelatin or their arbitrary composition) weight ratio is respectively 89.999%, 87.975%, 84.09%, 79.98%, 74.95% and 69.901%; bioadhesive substance (dopamine, bioadhesive peptide ( RGD), the mixture of any one or more in the extracellular matrix) weight ratio is respectively 10%, 12%, 15%, 20%, 25% and 30% fully mixed; The method of described mixing comprises: Bioadhesive substances are melted or dissolved in organic solvents to form solutions or suspensions, with hot-melt biocompatible materials (temperature higher than the melting point of the material, such as PLA temperature higher than 80 degrees Celsius), or with organic solvents (such as Dichlorome...

Embodiment 2

[0063] Embodiment 2 Preparation of catheter containing black phosphorus composition

[0064] The black phosphorus composition of the above-mentioned embodiment 1 is subjected to electrospinning to prepare catheters, and conventional electrospinning techniques are used to prepare various required catheters; or 3D printing technology is used to print various catheters; or catheter molds are used to prepare various required catheters. Needed catheters, such as single-layer black phosphorus or multilayer black phosphorus PLA catheters, single-layer black phosphorus or multilayer black phosphorus PCL catheters, single-layer black phosphorus or multilayer black phosphorus PCLA catheters, etc. can be prepared by the method of this embodiment . For example, 3D printing is used to prepare 1% black phosphorus PCL nerve guide (such as figure 1 (shown) has good nerve regeneration performance such as elastic modulus is better than pure PCL catheter prepared by 3D printing, the elastic m...

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Abstract

The invention provides a black phosphorus composition, a biological material containing the black phosphorus composition, a preparation method and application. The black phosphorus composition comprises the components, in percentages by weight, of 69.901% to 89.999% of a biocompatible material, 0.001% to 0.099% of black phosphorus and 10% to 30% of a bioadhesive substance. The biological materialcontaining the black phosphorus composition comprises a catheter, wherein the catheter is prepared from the black phosphorus composition; and a bioadhesive substance layer is arranged on the side wallof the catheter. The preparation method of the biological material comprises the steps of carrying out 3D printing, mold method or electrostatic spinning and the like on the black phosphorus composition to prepare the catheter, spraying a layer of bioadhesive substance inside the catheter by adopting 3D printing or electrostatic spinning, and carrying out crosslinking curing to obtain the biological material. The prepared catheter can promote regeneration, proliferation, differentiation and the like of nerves, muscles, bones, blood vessels and the like. In-vivo experiments show that the repair of animal peripheral nerve, muscle and the like, such as sciatic nerve and muscle, is superior to autologous nerve transplantation, and has practical and clinical application values.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a black phosphorus composition, a biological material containing the black phosphorus composition, a preparation method and an application thereof. Background technique [0002] Various biomedical stents and catheters currently include degradable and non-degradable stents or catheters. For example, polyethylene tubes have been used as nerve stents or catheters to study nerve regeneration. Due to the non-degradation of stents or catheters, nerve regeneration , If the stent or catheter is not treated, it may cause tissue fibrosis, cause inflammation and other toxic side effects, and the clinical application effect is not very satisfactory. At present, various biocompatible materials have been developed to prepare various biomedical scaffolds or catheters, such as collagen, polylactic acid, etc., but because these materials are used alone, there are some problems such as strengt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61L27/18A61L27/22A61L27/24A61L27/36A61L27/28A61L27/50A61L27/56A61L27/58
CPCA61L27/025A61L27/18A61L27/222A61L27/24A61L27/28A61L27/3633A61L27/50A61L27/56A61L27/58A61L2430/32C08L67/04
Inventor 袁伟恩钱运程媛郭晓霜徐阳陈璇
Owner SHANGHAI JIAO TONG UNIV
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