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Application of Xinhuang tablet in preparation of medicine for treating ulcerative colitis

A technology of ulcerative colitis and Xinhuang tablets, applied in the application field of medicine, can solve problems such as stomach discomfort, toxic side effects, and induction of chronic hepatitis

Inactive Publication Date: 2020-07-14
XIAMEN TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these western medicines generally have toxic and side effects. For example, mesalamine can cause stomach discomfort and other adverse reactions, and even induce chronic hepatitis; Edissa is prone to acute pancreatitis, nausea and vomiting and other adverse reactions.
In addition, corticosteroids, such as prednisone or dexamethasone, are also used for treatment in the prior art, but it is not considered that long-term hormone maintenance can prevent ulcerative colitis recurrence

Method used

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  • Application of Xinhuang tablet in preparation of medicine for treating ulcerative colitis
  • Application of Xinhuang tablet in preparation of medicine for treating ulcerative colitis
  • Application of Xinhuang tablet in preparation of medicine for treating ulcerative colitis

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] 1. Dextran sodium sulfate (DSS) was used to induce the establishment of an ulcerative colitis (UC) mouse animal model. Drug preparation, specific modeling and administration were as follows:

[0015] (1) Preparation of Xinhuang Tablet solution: Take an appropriate amount of Xinhuang Tablet powder and add it to distilled water to dissolve, the final drug concentration is 37.5 mg / ml, ultrasonically assisted dissolution, and store at 4°C.

[0016] (2) Establishment of ulcerative colitis (UC) mouse model and administration of Xinhuang tablet solution: Balb / c male mice with a body weight of 25-28g were used, and the mice were placed in a standard environment with a 12h light / dark cycle cycle. conditional environment. After 5 days of adaptive feeding, the mice were randomly divided into 3 groups (5 in each group): normal control group, DSS-induced UC model group (model group), and Xinhuang Tablet group.

[0017] The model group and the Xinhuang Tablet group were continuously...

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Abstract

The invention relates to the field of medical application of a Xinhuang tablet, in particular to application of the Xinhuang tablet in preparation of a medicine for treating ulcerative colitis. Pharmacological experiments and pharmacodynamic experiments find that the Xinhuang tablet has very excellent effects of treating the ulcerative colitis. Research finds that a Xinhuang tablet group can remarkably improve lesion sign conditions of the ulcerative colitis, has a certain improvement function on colon shortening caused by the ulcerative colitis and has a certain improvement function on the cytokine level abnormity of the ulcerative colitis.

Description

technical field [0001] The invention relates to the field of medical applications of Xinhuang Tablets, in particular to the application of Xinhuang Tablets in the preparation of medicines for treating ulcerative colitis. Background technique [0002] Ulcerative colitis is a chronic nonspecific inflammatory disease of the colon and rectum whose etiology is not yet clear, and the lesions are limited to the mucosa and submucosa of the large intestine. The lesions are mostly located in the sigmoid colon and rectum, and can also extend to the descending colon, or even the entire colon. The course of the disease is long and often recurrent. The disease is seen at any age, but it is most common in 20-30 years old. [0003] The initial manifestations of ulcerative colitis can take many forms. Bloody diarrhea is the most common early symptom. Other symptoms followed by abdominal pain, blood in the stool, weight loss, tenesmus, vomiting and so on. Occasionally the main manifestat...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K36/062A61K36/258A61K9/20A61P1/04A61P1/00A61K35/618A61K35/413A61K35/32
CPCA61K9/20A61K35/32A61K35/413A61K35/618A61K36/062A61K36/185A61K36/258A61K36/899A61K2236/19A61P1/00A61P1/04A61K2300/00
Inventor 关斌詹志学彭军陈友琴赖志成南淑华沈阿灵陈西翌许玉珍刘丽雅曾智发
Owner XIAMEN TRADITIONAL CHINESE MEDICINE
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