Paracetamol tablet and preparation method thereof

A technology for acetaminophen tablets and acetaminophen, which is applied to the field of acetaminophen tablets and their preparation, can solve problems such as splits, and achieve the effects of high dissolution rate, improved appearance qualification rate, and good stability

Pending Publication Date: 2020-06-19
GANSU LANYAO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The conventional prescription of acetaminophen tablets is prepared by selecting a single filler, binder, disintegrating agent, lubricant, etc. and adopting wet granulation technology, such as the Chinese patent application with publication number CN106214671A "A kind of koji hydrochloride containing Tramadol and acetaminophen preparation and its preparation method "Using lactose as filler, povidone K30 as disintegrant, magnesium stearate as lubricant, prepared by wet granulation process containing tramadol hydrochloride and acetaminophen A preparation of acetaminophen, which has simple process and easy operation, but if only lactose is used as filler, there will be cracks in large-scale industrial production

Method used

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  • Paracetamol tablet and preparation method thereof
  • Paracetamol tablet and preparation method thereof
  • Paracetamol tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: To prepare 1000 pieces of acetaminophen tablets (specification 0.3g), the following components were used:

[0020]

[0021] Preparation method: fully mix acetaminophen with corn starch and lactose, and micronize the resulting mixture to obtain fine powder mixture I with a particle size of 1-75 microns; similarly process hydroxypropyl methylcellulose Micronization treatment to obtain a fine powder with a particle size of 1-75 microns. Accurately weigh the specified amount of the fine powder and add it to a 20% ethanol solution and stir thoroughly to obtain a binder solution with a concentration of 3%. Weigh the formula amount Potassium sorbate was added to the binder solution, stirred and dissolved to obtain binder solution II; the remaining auxiliary materials were respectively crushed through a 100-mesh sieve, and set aside; the mixture I was mixed with the internally added cross-linked polyvinylpyrrolidone to obtain Mixture III: Slowly add the mixture II...

Embodiment 2

[0022] Example 2: To prepare 1000 pieces of acetaminophen tablets (specification 0.3g), use the following components

[0023]

[0024] Preparation method: fully mix acetaminophen with corn starch and lactose, and micronize the resulting mixture to obtain fine powder mixture I with a particle size of 1-75 microns; similarly process hydroxypropyl methylcellulose Micronization treatment to obtain a fine powder with a particle size of 1-75 microns. Accurately weigh the specified amount of the fine powder and add it to a 20% ethanol solution and stir thoroughly to obtain a binder solution with a concentration of 3%. Weigh the formula amount Potassium sorbate was added to the binder solution, stirred and dissolved to obtain binder solution II; the remaining auxiliary materials were respectively crushed through a 100-mesh sieve, and set aside; the mixture I was mixed with the internally added cross-linked polyvinylpyrrolidone to obtain Mixture III; slowly add the mixture III to th...

Embodiment 3

[0025] Example 3 To prepare 1000 pieces of acetaminophen tablets (specification 0.3g), use the following components

[0026]

[0027] Preparation method: fully mix acetaminophen with corn starch and lactose, and micronize the resulting mixture to obtain fine powder mixture I with a particle size of 1-75 microns; similarly process hydroxypropyl methylcellulose Micronization treatment to obtain a fine powder with a particle size of 1-75 microns. Accurately weigh the specified amount of the fine powder and add it to a 20% ethanol solution and stir thoroughly to obtain a binder solution with a concentration of 3%. Weigh the formula amount Potassium sorbate was added to the binder solution, stirred and dissolved to obtain binder solution II; the remaining auxiliary materials were respectively crushed through a 100-mesh sieve, and set aside; the mixture I was mixed with the internally added cross-linked polyvinylpyrrolidone to obtain Mixture III; slowly add the mixture III to the...

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Abstract

The invention discloses a paracetamol tablet. The paracetamol tablet is composed of paracetamol, a filler, a binder, a disintegrating agent, a lubricant and a stabilizer, wherein when an appropriate amount of stabilizer is added into the binder, the stability of the dissolution rate can be significantly improved. The invention also discloses a preparation method of the paracetamol tablet. The method uses a micronization technology to process the raw and auxiliary materials, so that the fusion of the raw and auxiliary materials can be improved, the tabletting time can be shortened, and the production costs can be saved. The finally prepared paracetamol tablet has a bright and clean appearance, a high dissolution rate, good stability and easy storage, and is suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and specifically discloses a paracetamol tablet and a preparation method thereof. Background technique [0002] The elderly and children with weak constitutions and poor immunity are the main groups infected with viruses and bacteria. When the seasons change, the number of people with high fever due to infection increases sharply. Sustained high fever can cause cramps, affect metabolism and blood circulation, and in severe cases can cause brain damage or even death. At this time, it is particularly important to choose an antipyretic that is suitable for all ages. Acetaminophen, also known as paracetamol, selectively inhibits the synthesis of prostaglandins in the hypothalamus thermoregulation center by inhibiting cyclooxygenase, causing peripheral blood vessels to dilate and sweating to achieve antipyretic effect. It is a relatively mild side effect Drugs generally do not cause adverse...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/167A61K47/38A61K47/12A61P29/00
CPCA61K9/2013A61K9/2054A61K31/167A61P29/00
Inventor 王志锋包正学包玉莉苏海燕安玉洁刘辉年
Owner GANSU LANYAO PHARMA CO LTD
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