A kind of polymer composite bacterial cellulose loaded zinc oxide antibacterial material and its preparation method and application

Abstract

The invention discloses a zinc oxide antibacterial material loaded on high polymer composite bacterial cellulose, a preparation method and application thereof. The antibacterial material is added into the fermentation medium with sodium alginate or carboxymethyl cellulose as an additive, and the bacterial cellulose is combined with sodium alginate or sodium carboxymethyl cellulose during synthesis. The fermentation product has the carboxyl group in sodium alginate or sodium carboxymethyl cellulose, and the carboxyl group is used to combine with zinc ions, and the nano-zinc oxide is loaded on the polymer composite bacterial cellulose through microwave high temperature and high pressure hydrothermal reaction. The method can effectively increase the loading capacity of the nanometer zinc oxide in the bacterial cellulose, and provide stable loading. And this method is more environmentally friendly than traditional chemical grafting, and does not require the use of highly corrosive chemicals. Polymer composite bacterial cellulose-supported zinc oxide antibacterial material Bacterial cellulose with good biocompatibility has antibacterial properties and can be applied to some body surface wounds.

Description

technical field [0001] The invention belongs to the field of materials, and in particular relates to a high-polymer composite bacterial cellulose-supported zinc oxide antibacterial material and a preparation method and application thereof. Background technique [0002] Bacterial cellulose (BC) is formed by the growth and assembly of bacteria itself, and has a natural nanometer three-dimensional network structure. Bacterial cellulose has a high ability to bind water, has a larger surface area than plant fibers, and has a higher chemical adsorption capacity. Bacterial cellulose has high biocompatibility, adaptability and good biodegradability, and is widely used in various fields of tissue engineering. Due to the good mechanical properties and excellent water retention capacity of bacterial cellulose materials, their application in wound dressings has attracted great attention. In the clinical process, body surface wounds are often accompanied by infection, and bacterial cel...

AI Technical Summary

Problems solved by technology

In the clinical process, body surface wounds are often accompanied by infection, and bacterial cellulose itself has no antibacterial and antibacterial ability, so it is difficult to be used in body surface wounds. Therefore, the needs of clinical practice put forward new requirements for bacterial cellulose wound dressings , there is an urgent need for a bacterial cellulose material with good antibacterial properties

[0003] In the prior art, the antibacterial and antibacterial function of bacterial cellulose is generally realized by loading nano silver by soaking method. Although the antibacterial properties of nano silver have been widely recognized, the bioaccumulation and toxic side effects caused by its long-term and large-scale use can no longer be ignored. ; and the method of soaking is adopted to realize the loading of nanomaterials through osmosis. On the one hand, the loading capacity of nanomaterials is very limited, and on the other hand, the combination stability of nanomaterials in bacterial cellulose is poor, and it is easy to fall off and free