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Conductive nerve repair material with micro-nano topological structure and preparation method and application thereof

A topology and nerve repair technology, applied in pharmaceutical formulations, prostheses, drug delivery, etc., to achieve the effect of low cost and simple process

Active Publication Date: 2020-06-12
广州市斌鹏生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are few studies on the combination of physical topology and electrical stimulation applied to the construction of peripheral nerve repair materials

Method used

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  • Conductive nerve repair material with micro-nano topological structure and preparation method and application thereof
  • Conductive nerve repair material with micro-nano topological structure and preparation method and application thereof
  • Conductive nerve repair material with micro-nano topological structure and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Use CAD software to draw the top view of the micro-nano topological structure pattern, the groove spacing is 200 μm, the groove width is 25 μm, and a mask is made, and the micro-nano groove is prepared on the silicon wafer by photolithography technology using the mask Groove structure, and then cast PDMS prepolymer on the silicon wafer, after cross-linking and curing, a PMDS stamp with micro-nano groove structure is obtained.

[0039] (2) Weigh 20g of PLGA in 50ml of dichloromethane, stir the solution with a magnetic stirrer at a stirring rate of 150 r / min, and stir for 48 hours to form a uniform PLGA solution.

[0040] (3) Add 1.0g of PEDOT to a 50ml centrifuge tube, add 30ml of absolute ethanol to ultrasonically disperse evenly, then add the dispersion to the PLGA solution in step (2), continue to stir for 3 days, and carry out ultrasonic oscillation, stirring speed 150 r / min, stirring for 48h to form a PLGA / PEDOT composite solution.

[0041] (4) In the fume hood...

Embodiment 2

[0045] (1) Use CAD software to draw the top view of the 3D micro-groove pattern, the groove pitch is 200 μm, the groove width is 50 μm, and a mask is made, and the mask is used to prepare 3D micro-grooves on the silicon wafer by photolithography pattern, and then cast PDMS prepolymer on the silicon wafer, and obtain a PMDS substrate with a 3D micro-groove pattern after cross-linking and curing.

[0046] (2) Weigh 20g of PLGA in 50ml of dichloromethane, stir the solution with a magnetic stirrer at a stirring rate of 150 r / min, and stir for 48 hours to form a uniform PLGA solution.

[0047] (3) Add 1.0g of PEDOT to a 50ml centrifuge tube, add 30ml of absolute ethanol to ultrasonically disperse evenly, then add the dispersion to the PLGA solution in step (2), and continue to stir for 3 days at a stirring rate of 150 r / min , stirred for 48h to form a PLGA / PEDOT composite solution.

[0048] (4) In the fume hood, the solvent in the composite solution obtained in step (3) was volatili...

Embodiment 3

[0052] (1) Use CAD software to draw the top view of the 3D micro-groove pattern, the groove pitch is 200 μm, the groove width is 100 μm, and a mask is made, and the mask is used to prepare 3D micro-grooves on the silicon wafer by photolithography pattern, and then cast PDMS prepolymer on the silicon wafer, and obtain a PMDS substrate with a 3D micro-groove pattern after cross-linking and curing.

[0053] (2) Weigh 20g of PLGA in 50ml of dichloromethane, stir the solution with a magnetic stirrer at a stirring rate of 150 r / min, and stir for 48 hours to form a uniform PLGA solution.

[0054] (3) Add 1.0g of PEDOT to a 50ml centrifuge tube, add 30ml of absolute ethanol to ultrasonically disperse evenly, then add the dispersion to the PLGA solution in step (2), and continue to stir for 3 days at a stirring rate of 150 r / min , stirred for 48h to form a PLGA / PEDOT composite solution.

[0055] (4) In the fume hood, the solvent in the composite solution obtained in step (3) was volat...

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Abstract

The invention discloses a conductive nerve repair material with a micro-nano topological structure and a preparation method and application thereof, and belongs to the field of biomedical materials. The preparation method comprises the following steps: preparing a PDMS substrate with a micro-nano groove topological structure by utilizing a soft photoetching technology and a melt film casting process; dissolving a polylactic acid-glycolic acid copolymer in an organic solvent, adding poly (3, 4-ethylenedioxythiophene), and evaporating the solvent to obtain a uniformly dispersed PLGA / PEDOT composite material; uniformly spreading the obtained composite material on a PDMS substrate, carrying out heating, melting and film casting treatment, cooling, and stripping the film from the PDMS substrate, thereby obtaining the conductive nerve repair material with the micro-nano topological structure. The preparation process is simple, the cost is low, and the obtained film combines the advantages ofconductive macromolecules and surface patterning and can be applied to preparation of a peripheral nervous tissue engineering scaffold.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a conductive nerve repair material with a micro-nano topological structure and a preparation method and application thereof. Background technique [0002] The process of peripheral nerve repair and functional recovery is accompanied by the generation of bioelectricity. As an important physiological factor, bioelectricity participates in many biological processes, such as maintaining cell stability, embryonic development, and wound healing. Poly 3,4-ethylenedioxythiophene (PEDOT) has high electrical conductivity, stability, good mechanical properties, good ability to control the release of biomolecules and good biocompatibility, and is widely used in biomedicine Engineering field has great potential application value. At present, PEDOT is mainly used in biosensor materials, drug controlled release, neural probes, etc. in the biomedical field. There are few domest...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08L67/04C08L65/00A61L27/48A61L27/50
CPCA61L27/48A61L27/50A61L2400/12A61L2430/32C08J5/18C08J2367/04C08J2465/00C08L67/04C08L65/00
Inventor 高会场卫应奇
Owner 广州市斌鹏生物科技有限公司
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