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Preparation method of novel bionic skin wound dressing based on MAP-PRF compounding

A wound and skin technology, applied in the field of preparation of new bionic skin wound dressings, can solve the problems of restricted normal activities, difficulty in closing wounds, and fixing wounds, etc., to reduce the risk of reinfection, have high adhesion, and ensure normal activities. Effect

Inactive Publication Date: 2020-06-12
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a preparation method of a novel bionic skin wound dressing based on MAP-PRF composite, which solves the problem that the dressing fixes the wound existing in the prior art, so that normal activities are limited and the wound is difficult to close.

Method used

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  • Preparation method of novel bionic skin wound dressing based on MAP-PRF compounding
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  • Preparation method of novel bionic skin wound dressing based on MAP-PRF compounding

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preparation example Construction

[0043]Preparation of adhesive extract: Add 0.9% sodium chloride injection to the aseptic material to be tested at a concentration ratio of 0.02 g / mL, extract in a closed glass container at 37°C for 24 hours, absorb the supernatant and pass through Filter through a 0.22 μm sterile filter to obtain a material extract.

[0044] The prepared wound adhesive belongs to the third class of medical devices in clinical use, so the samples to be tested are evaluated for biological safety according to the ISO10993 series of national standards GB / T16886.12 Biological Evaluation Standards for Medical Devices.

[0045] The cell suspension in the logarithmic growth phase was divided into 1×10 4 cells / mL were inoculated in a 96-well culture plate, 200 μL per well, and then placed in a carbon dioxide incubator for 24 hours. The positive control group (cells were cultured in 5% DMSO), the experimental group (cells were cultured in 0.25%, 0.5%, 0.75%, and 1% adhesive extracts respectively) were ...

Embodiment 1

[0052] A kind of preparation method of the novel bionic skin wound dressing based on MAP-PRF compound, concretely carry out according to the following steps:

[0053] Step 1, add polymeric alcohol to the dry cyanate, keep the R index, that is, the molar ratio of -NCO / -OH is 2:1, stir evenly, then add dry DMF, the molar ratio of polymeric alcohol and DMF is 1:20 , and reacted for 4h under a nitrogen atmosphere to obtain a polyurethane prepolymer;

[0054] Step 2, add chain extender and catalyst to polyurethane prepolymer, the ratio of polyurethane prepolymer and chain extender is 1:2.4, the ratio of polyurethane prepolymer and catalyst is 1:0.2, stir evenly, in nitrogen atmosphere Carry out the chain extension reaction under the following conditions, the reaction time is 4h, obtain the chain extension reaction product, wherein, the chain extender is dimethylolpropionic acid, and the catalyst is dibutyltin dilaurate;

[0055] Step 3, after the chain extension reaction is comple...

Embodiment 2

[0059] A kind of preparation method of the novel bionic skin wound dressing based on MAP-PRF compound, concretely carry out according to the following steps:

[0060] Step 1, add polymeric alcohol to the dry cyanate, keep the R index, that is, the molar ratio of -NCO / -OH is 2:1.2, stir evenly, then add dry DMF, the molar ratio of polymeric alcohol and DMF is 1:15 , and reacted for 6h under a nitrogen atmosphere to obtain a polyurethane prepolymer;

[0061] Step 2, add chain extender and catalyst to polyurethane prepolymer, the ratio of polyurethane prepolymer and chain extender is 1:2, the ratio of polyurethane prepolymer and catalyst is 1:0.3, stir evenly, in nitrogen atmosphere Carry out the chain extension reaction under the following conditions, the reaction time is 3h, obtain the chain extension reaction product, wherein, the chain extender is dimethylolpropionic acid, and the catalyst is dibutyltin dilaurate;

[0062] Step 3, after the chain extension reaction is comple...

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Abstract

The invention discloses a preparation method of a novel bionic skin wound dressing based on MAP-PRF compounding. Mussel adhesive protein MAP is used as a base material for biomimetic synthesis of an adhesive material MAP to carry out PRF bio-extraction and modify the MAP adhesive material. The prepared wound adhesive overcomes the defects of traditional wound treatment and repair modes such as traditional skin dressing, postoperative suture and the like; the problems that the wound is not easy to fix, needs to be waterproof, needs to be subjected to wound dressing change and the like, or activity is limited, the wound cannot be kept moist and stitches need to be removed due to wound fixing are solved, normal activity of a wounded person can be guaranteed, the re-infection risk is reduced,and wide applicability is achieved.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and relates to a preparation method of a novel bionic skin wound dressing based on MAP-PRF composite. Background technique [0002] Traditional wound treatment and repair methods such as skin dressing coverage, postoperative suture, etc., or focus on wound coverage and healing, are not easy to fix, need to pay attention to waterproofing when using, need to change wound dressings, etc., or fix the wound so that normal activities are limited and unable to Keeping the wound moist and requiring stitches to be removed has many application limitations, often restricting the wounded from performing normal activities, and there is a risk of re-infection. Go beyond the limitations of traditional wound treatment and repair methods, overcome the above-mentioned defects, realize rapid wound closure and avoid re-infection, and at the same time, simulate skin function and promote wound healing, and d...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/32A61L15/42A61L15/44
CPCA61L15/26A61L15/32A61L15/42A61L15/44A61L2300/252A61L2300/412C08L89/00C08L75/04
Inventor 成昭徐浩郑蕾何昊苗延青
Owner XIAN MEDICAL UNIV
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