Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Aescin injectable hydrogel, and preparation method and application thereof

A technique of aescin and water for injection, which is applied to the field of aescin injectable hydrogel and its preparation, can solve the problems of no sustained release effect, side effects, poor treatment effect and the like, and achieves a simple, green and safe preparation method. High, avoid the effect of fast clearing

Active Publication Date: 2020-06-09
CENT SOUTH UNIV
View PDF5 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinical forms of aescin mainly include sodium aescinate freeze-dried powder, sodium aescinate liniment, compound sodium aescinin gel, sodium aescinin injection and sodium aescinate tablets, etc. It is administered orally, intravenously or externally. These drug dosage forms basically have no sustained-release effect, the therapeutic effect is not good, and systemic administration will bring certain side effects to the body.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Aescin injectable hydrogel, and preparation method and application thereof
  • Aescin injectable hydrogel, and preparation method and application thereof
  • Aescin injectable hydrogel, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh aescin powder into a screw bottle, add 1mL of 0.1M PBS buffer solution (pH=8.0-12.0) or 1mL of 0.1M NaOH (or KOH) solution, raise the temperature to 50°C, and sonicate for 8min to make It is completely dissolved to obtain an aescin solution, the concentration of the aescin is 1.0%wt, and the aescin injectable hydrogel is obtained after standing at room temperature for 5 hours.

[0036] A digital camera was used to record the appearance of the escin injectable hydrogel. figure 1 It is the appearance diagram of aescin injectable hydrogel. Such as figure 1 As shown, the appearance of the aescin injectable hydrogel is colorless, uniform and transparent jelly-like.

Embodiment 2

[0038] Weigh aescin powder into a screw bottle, add 1mL of 0.1M PBS buffer solution (pH=8.0-12.0) or 1mL of 0.1M NaOH (or KOH) solution, raise the temperature to 60°C, and sonicate for 4min to make It is completely dissolved to obtain an aescin solution, the concentration of the aescin is 1.5%wt, and the aescin injectable hydrogel is obtained after standing at room temperature for 3 hours.

Embodiment 3

[0040] Weigh aescin powder into a screw bottle, add 1mL of 0.1M PBS buffer solution (pH=8.0-12.0) or 1mL of 0.1M NaOH (or KOH) solution, raise the temperature to 70°C, and sonicate for 3min to make It is completely dissolved to obtain an aescin solution, the concentration of the aescin is 2.0%wt, and the aescin injectable hydrogel is obtained by standing at room temperature for 1 hour.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an aescin injectable hydrogel, and a preparation method and application thereof. The aescin injectable hydrogel is a hydrogels formed by self-assembly of aescin in an alkalineaqueous solution, and the preparation method is to dissolve aescin in the alkaline aqueous solution and then perform standing. The aescin injectable hydrogel has performance of shear thinning and self-repairing, does not need chemical modification and auxiliary additives, does not need additional drug carrier materials, and can be injected for administration directly. The aescin injectable hydrogel is good in sustained release, high in drug utilization, high in safety and good in therapeutic effect, and the preparation method is simple.

Description

technical field [0001] The invention relates to the technical field of aescin preparations, in particular to an injectable hydrogel of aescin and its preparation method and application. Background technique [0002] Hydrogel is a gel with water as the dispersion medium, and its appearance is semi-solid like jelly. Traditional hydrogels are formed by cross-linking polymer chains to form a three-dimensional network structure, and the three-dimensional network structure binds a large amount of water. Different from traditional hydrogels, small-molecule hydrogels are formed by self-assembly of small molecules in water using non-covalent bonds. They have the advantages of good biocompatibility, easy degradation, and fast absorption. They are used in drug delivery, cell culture, Tissue engineering and other biomedical fields have broad application prospects. [0003] Most of the clinically used drugs exist in the form of oral capsules or tablets, but some drugs have problems suc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/06A61K31/704A61K47/02A61K36/185A61P7/10A61P9/14A61P29/00A61P35/00A61K131/00
CPCA61K9/0024A61K9/06A61K31/704A61K36/185A61K47/02A61P7/10A61P9/14A61P29/00A61P35/00
Inventor 张翼郑俊王杨朱剑熹倪雅琼
Owner CENT SOUTH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products