Aescin injectable hydrogel, and preparation method and application thereof
A technique of aescin and water for injection, which is applied to the field of aescin injectable hydrogel and its preparation, can solve the problems of no sustained release effect, side effects, poor treatment effect and the like, and achieves a simple, green and safe preparation method. High, avoid the effect of fast clearing
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Embodiment 1
[0035] Weigh aescin powder into a screw bottle, add 1mL of 0.1M PBS buffer solution (pH=8.0-12.0) or 1mL of 0.1M NaOH (or KOH) solution, raise the temperature to 50°C, and sonicate for 8min to make It is completely dissolved to obtain an aescin solution, the concentration of the aescin is 1.0%wt, and the aescin injectable hydrogel is obtained after standing at room temperature for 5 hours.
[0036] A digital camera was used to record the appearance of the escin injectable hydrogel. figure 1 It is the appearance diagram of aescin injectable hydrogel. Such as figure 1 As shown, the appearance of the aescin injectable hydrogel is colorless, uniform and transparent jelly-like.
Embodiment 2
[0038] Weigh aescin powder into a screw bottle, add 1mL of 0.1M PBS buffer solution (pH=8.0-12.0) or 1mL of 0.1M NaOH (or KOH) solution, raise the temperature to 60°C, and sonicate for 4min to make It is completely dissolved to obtain an aescin solution, the concentration of the aescin is 1.5%wt, and the aescin injectable hydrogel is obtained after standing at room temperature for 3 hours.
Embodiment 3
[0040] Weigh aescin powder into a screw bottle, add 1mL of 0.1M PBS buffer solution (pH=8.0-12.0) or 1mL of 0.1M NaOH (or KOH) solution, raise the temperature to 70°C, and sonicate for 3min to make It is completely dissolved to obtain an aescin solution, the concentration of the aescin is 2.0%wt, and the aescin injectable hydrogel is obtained by standing at room temperature for 1 hour.
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