Long-acting renewable antibacterial coating on surface of titanium implant

Abstract

The invention relates to a long-acting renewable antibacterial coating on the surface of a titanium implant, and belongs to the field of oral biomedical materials. The invention provides a method forpreparing the renewable antibacterial coating on the surface of the titanium implant. The method comprises the following steps that a titanium sheet is taken and polished with SiC abrasive paper, andthe titanium sheet is cleaned with a solvent and aired; then alkali heat treatment is carried out, and the titanium sheet is treated with a silane coupling agent KH570; and then the titanium sheet acts with ethylene diamine after carrying out free radical polymerization reaction with acrylic acid monomer, then the titanium sheet is soaked in a sodium hypochlorite solution, and the renewable antibacterial coating on the surface of the titanium implant is prepared. According to the long-acting renewable antibacterial coating on the surface of the titanium implant, a firm and stable macromolecular antibacterial layer is constructed on the surface of the titanium sheet by adopting a covalent bonding method and a polymer grafting method, so that the effect of lasting antibacterial is achieved;and according to the long-acting renewable antibacterial coating on the surface of the titanium implant, halamine polymer is applied to the surface modification of the titanium implant for the first time, the antibacterial coating capable of being recycled is constructed, the antibacterial layer is firm and stable, the antibacterial time is long, and the antibacterial layer can be recycled.

Description

Technical field [0001] The invention relates to a long-lasting regenerable antibacterial coating on the surface of titanium implants, and belongs to the field of oral biomedical materials. Background technique [0002] At present, implant denture restoration has become the preferred way to restore the function and aesthetics of missing teeth. Since the tissue around the implant is different from the natural periodontal tissue, its defense ability against bacterial invasion is relatively weak. Especially when implanted under adverse microecological environment conditions such as periodontal disease, maxillofacial defects, and infected alveolar sockets, implants are more likely to develop. Peripheral tissue infection or peri-implantitis is difficult to cure once it occurs. The current incidence rate of peri-implantitis is as high as 18%-35%, which is an important reason for the long-term failure of implant restoration. [0003] N-halamine compounds are organic non-antibiotic...

AI Technical Summary

Problems solved by technology

However, in the existing research, the antibacterial coating formed by combining the antibacterial agent on the titanium surface through physical adsorption or hydrogen bonding has a low degree of firmness, and the antibacterial components can be separated quickly; And other substances are applied to titanium surface modification, and the sustained release rate and efficiency decrease rapidly over time

Therefore, the performance of the antibacterial coating on the surface of the implant is still difficult to achieve the expected antibacterial timeliness, and it is difficult to effectively prevent post-implant infection.

In addition, when the host or environmental factors lead to peri-implantitis, bone resorption around the implant, exposure of the implant, and further adhesion of plaque will eventually lead to loosening and detachment of the implant. This process is often irreversible. Surface antibacterial coating In the long-term of implant restoration, the antibacterial activity on the surface of the implant has basically disappeared, and it is difficult to effectively treat peri-implantitis

At present, the antibacterial coating structure on the surface of implants has some defects such as stability, controllability, and timeliness are not ideal, and antibacterial properties cannot be regenerated.

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