A kind of preparation method of low permeability wet tissue liquid medicine system

A technology for liquid medicine and wet wipes, which is applied in the field of preparation of liquid medicine systems for low-permeability wet wipes, can solve problems affecting consumer experience, difficulty in use, sticky cellulose feel, etc., and achieve high social, economic and environmental significance. Low cost, refreshing effect

Active Publication Date: 2022-07-05
FUJIAN HENGAN HLDG CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the sticky feel of cellulose, which affects the user experience of consumers, and the conflict between carbomer and most antiseptics and fungicides, it is difficult to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0023] Preparation of nanoscale cellulose:

[0024] The natural mango lotus plant is crushed to a length of 3cm-5cm, mixed with 2-5wt% sulfuric acid solution for hydrolysis, and filtered to obtain filter residue; Then the delignified product is obtained; the delignified product is immersed in a 40-70% aqueous solution of zinc chloride at room temperature, with a liquid ratio of 1:25, stirred for 30-50 min, filtered, washed with water until neutral, and then replaced with acetone and dried. Pulverize to obtain cellulose powder; mix the cellulose powder with water to obtain an aqueous solution of cellulose with a concentration of 0.01 mol / L, add rutile-type nano-titanium dioxide with a mass of 1% of the aqueous cellulose solution under stirring, and under vacuum conditions, 300W xenon lamp irradiated with 200W ultrasonic radiation for 2-3 hours to obtain cellulose precursor by oxidative degradation; sodium cyclohexyl sulfamate was added to the fiber precursor, reacted at 60-80 °...

Embodiment 1

[0026] The wet tissue liquid system formula is: sodium alkyl benzene sulfonate 3.5%, fatty alcohol polyoxyethylene ether sulfuric acid 1.5%, glycerin 3.5%, triadimenol 0.06%, nano-cellulose 0.8%, essence 0.01%, pure water margin.

[0027] The components of the wet tissue liquid are physically mixed together, wherein, after adding nano-scale cellulose, the pH value of the liquid system is adjusted with triethanolamine at room temperature in the range of 9.0-9.5, so that the nano-scale cellulose can be uniformly dispersed and not. Agglomeration will occur, and then the pH value of the liquid medicine system is adjusted to the range of 4.5-5.5 with citric acid to form a stable low-osmotic liquid medicine system, and the rotational viscosity of the system is controlled at 200-300Pa.s.

Embodiment 2

[0029] The formula of the wet tissue liquid system is: Coco acid monoisopropanolamide 2.5%, alkyl glycoside 1.5%, bisabolol 0.8%, 1,2-hexanediol 0.5%, thiabendazole 1.2%, nanoscale Cellulose 0.1%, essence 0.01%, pure water balance.

[0030] In the embodiment of the present invention, the preparation method of the wet tissue liquid medicine system is the same as that of embodiment 1.

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Abstract

The invention relates to the technical field of wet wipes, and in particular to a method for preparing a low-osmotic wet tissue liquid medicine system, comprising wet tissue liquid medicine and nanoscale cellulose with a mass fraction of 0.04-0.2% of the wet tissue liquid medicine. After adding nano-scale cellulose to the wet tissue liquid, adjust the pH value of the liquid system to 9.0-9.5 with triethanolamine at room temperature, so that the nano-scale cellulose can be dispersed evenly without agglomeration, and then use citric acid to disperse the drug. The pH value of the liquid system is adjusted to the range of 4.5-5.5 to form a stable low-osmotic liquid system, and the rotational viscosity of the system is controlled at 200-300Pa.s. The present invention utilizes nanocellulose to effectively increase the viscosity of the wet tissue liquid, reduce its fluidity, reduce the infiltration of the wet tissue liquid, and at the same time feel refreshing, without the stickiness problem of using conventional thickeners, and can be used with most antiseptics and sterilization. It can be used in combination and has a wide range of applications.

Description

technical field [0001] The invention relates to the technical field of wet wipes, in particular to a preparation method of a liquid medicine system for wet wipes with low permeability. Background technique [0002] At present, the 80-piece large package of wet wipes is due to the addition of detergents and antiseptic bactericides in the liquid system, which greatly reduces the surface tension of the liquid and increases the fluidity of the liquid, which is easy to cause infiltration, resulting in the upper layer of wet wipes in the same package being dry and the bottom layer wet The towel is wet, and its liquid content is even more than doubled, making it inconvenient for consumers to use. The conventional method is to use cellulose or carbomer thickener to increase the viscosity of the liquid medicine and reduce the fluidity of the liquid medicine to reduce the infiltration of the liquid medicine. However, because the sticky feel of cellulose affects the experience of cons...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/73A61K8/29A61K8/02A61Q19/10C08B15/10C08J3/28C08L1/02
CPCA61K8/731A61K8/736A61K8/29A61K8/0208A61Q19/10C08B15/10C08J3/28A61K2800/84A61K2800/82A61K2800/524A61K2800/81C08J2301/02
Inventor 蔡增雄马宏强许贵珠
Owner FUJIAN HENGAN HLDG CO LTD
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